Disease
Javorsky A, Humbert PO, Kvansakul M. Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain. Communications Biology. 2021 Jun 11;4(1):724. doi: 10.1038/s42003-021-02250-7.; Ordonez AA, Bullen CK, Villabona-Rueda AF, Thompson EA, Turner ML, Davis SL, Komm O, Powell JD, D'Alessio FR, Yolken RH, Jain SK, Jones-Brando L. Sulforaphane exhibits in vitro and in vivo antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses. bioRxiv. 2021 Mar 25;(). PMID: 33791708; PMCID: PMC8010735.; Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang H, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK. Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature Communications. 2020 Oct 21;11(1):5419. doi: 10.1038/s41467-020-19363-y.; Wynn D, Lategan TW, Sprague TN, Rousseau FS, Fox EJ. Monomethyl fumarate has better gastrointestinal tolerability profile compared with dimethyl fumarate. Multiple Sclerosis and Related Disorders. 2020 Oct;45():102335. doi: 10.1016/j.msard.2020.102335.; Toto A, Ma S, Malagrinò F, Visconti L, Pagano L, Stromgaard K, Gianni S. Comparing the binding properties of peptides mimicking the Envelope protein of
Metabolites
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane
Formula: C27H48O3 (420.36032579999994)
CAS ID: 547-96-6
(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
Formula: C20H20N4O (332.163703)
CAS ID: 841258-76-2
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.11.1.- | |||
| 1.1.1.10 | L-xylulose reductase | xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming) | |
| 1.1.1.100 | 3-oxoacyl-[acyl-carrier-protein] reductase | (3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase | |
| 1.1.1.205 | IMP dehydrogenase | IMP:NAD+ oxidoreductase | |
| 1.1.1.42 | isocitrate dehydrogenase (NADP+) | isocitrate:NADP+ oxidoreductase (decarboxylating) | |
| 1.1.98.2 | glucose-6-phosphate dehydrogenase (coenzyme-F420) | D-glucose-6-phosphate:F420 1-oxidoreductase | |
| 1.11.1.2 | NADPH peroxidase | NADPH:hydrogen-peroxide oxidoreductase | |
| 1.11.1.21 | catalase-peroxidase | donor:hydrogen-peroxide oxidoreductase | |
| 1.11.1.24 | thioredoxin-dependent peroxiredoxin | thioredoxin:hydroperoxide oxidoreductase | |
| 1.11.1.27 | glutathione-dependent peroxiredoxin | glutathione:hydroperoxide oxidoreductase | |
| 1.11.1.28 | lipoyl-dependent peroxiredoxin | lipoyl:hydroperoxide oxidoreductase | |
| 1.11.1.29 | mycoredoxin-dependent peroxiredoxin | mycoredoxin:hydroperoxide oxidoreductase | |
| 1.11.1.9 | glutathione peroxidase | glutathione:hydrogen-peroxide oxidoreductase | |
| 1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase | [histone H3]-N6,N6-dimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase | |
| 1.14.13.39 | nitric-oxide synthase (NADPH) | L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) | |
| 1.14.14.18 | heme oxygenase (biliverdin-producing) | protoheme,NADPH-hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) | |
| 1.14.14.24 | vitamin D 25-hydroxylase | calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating) | |
| 1.14.16.1 | phenylalanine 4-monooxygenase | L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) | |
| 1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase | [histone H3]-N6,N6-dimethyl-L-lysine4:acceptor oxidoreductase (demethylating) | |
| 1.15.1.1 | superoxide dismutase | superoxide:superoxide oxidoreductase | |
| 1.16.1.6 | cyanocobalamin reductase | cob(II)alamin, hydrogen cyanide:NADP+ oxidoreductase | |
| 1.16.1.8 | [methionine synthase] reductase | [methionine synthase]-methylcob(III)alamin,S-adenosyl-L-homocysteine:NADP+ oxidoreductase | |
| 1.16.1.9 | ferric-chelate reductase (NADPH) | Fe(II)-siderophore:NADP+ oxidoreductase | |
| 1.16.3.1 | ferroxidase | Fe(II):oxygen oxidoreductase | |
| 1.16.3.4 | cuproxidase | copper(I):oxygen oxidoreductase | |
| 1.17.4.1 | ribonucleoside-diphosphate reductase | 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase | |
| 1.18.1.6 | adrenodoxin-NADP+ reductase | adrenodoxin:NADP+ oxidoreductase | |
| 1.2.4.4 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) | 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) | |
| 1.3.1.39 | enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) | acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific) | |
| 1.4.3.21 | primary-amine oxidase | primary-amine:oxygen oxidoreductase (deaminating) | |
| 1.4.3.4 | monoamine oxidase | amine:oxygen oxidoreductase (deaminating) | |
| 1.6.3.1 | NAD(P)H oxidase (H2O2-forming) | NAD(P)H:oxygen oxidoreductase (H2O2-forming) | |
| 1.8.1.4 | dihydrolipoyl dehydrogenase | protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | |
| 1.8.1.9 | thioredoxin-disulfide reductase | thioredoxin:NADP+ oxidoreductase | |
| 1.8.4.2 | protein-disulfide reductase (glutathione) | glutathione:protein-disulfide oxidoreductase | |
| 2.1.1.13 | methionine synthase | 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase | |
| 2.1.1.319 | type I protein arginine methyltransferase | S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming) | |
| 2.1.1.356 | [histone H3]-lysine27 N-trimethyltransferase | S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase | |
| 2.1.1.37 | DNA (cytosine-5-)-methyltransferase | S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase | |
| 2.1.1.56 | mRNA (guanine-N7)-methyltransferase | S-adenosyl-L-methionine:mRNA (guanine-N7)-methyltransferase | |
| 2.1.1.57 | methyltransferase cap1 | S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase | |
| 2.1.1.6 | catechol O-methyltransferase | S-adenosyl-L-methionine:catechol O-methyltransferase | |
| 2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase | 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase | |
| 2.2.1.2 | transaldolase | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase | |
| 2.3.1.1 | amino-acid N-acetyltransferase | acetyl-CoA:L-glutamate N-acetyltransferase | |
| 2.3.1.12 | dihydrolipoyllysine-residue acetyltransferase | acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase | |
| 2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase | phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase | |
| 2.3.1.168 | dihydrolipoyllysine-residue (2-methylpropanoyl)transferase | 2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase | |
| 2.3.1.250 | [Wnt protein] O-palmitoleoyl transferase | (9Z)-hexadec-9-enoyl-CoA:[Wnt]-L-serine O-hexadecenoyltransferase | |
| 2.3.1.38 | [acyl-carrier-protein] S-acetyltransferase | acetyl-CoA:[acyl-carrier protein] S-acetyltransferase | |
| 2.3.1.39 | [acyl-carrier-protein] S-malonyltransferase | malonyl-CoA:[acyl-carrier protein] S-malonyltransferase | |
| 2.3.1.41 | beta-ketoacyl-[acyl-carrier-protein] synthase I | acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating) | |
| 2.3.1.48 | histone acetyltransferase | acetyl-CoA:[protein]-L-lysine acetyltransferase | |
| 2.3.1.85 | fatty-acid synthase system | acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) | |
| 2.3.1.97 | glycylpeptide N-tetradecanoyltransferase | tetradecanoyl-CoA:N-terminal-glycine-[protein] N-tetradecanoyltransferase | |
| 2.3.2.2 | gamma-glutamyltransferase | (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase | |
| 2.3.2.23 | E2 ubiquitin-conjugating enzyme | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase | |
| 2.3.2.24 | (E3-independent) E2 ubiquitin-conjugating enzyme | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent) | |
| 2.3.2.26 | HECT-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming) | |
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.3.2.32 | cullin-RING-type E3 NEDD8 transferase | [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type) | |
| 2.3.2.36 | RING-type E3 ubiquitin transferase (cysteine targeting) | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (thioester bond-froming; RING-type) | |
| 2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-(1->3)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | |
| 2.4.1.109 | dolichyl-phosphate-mannose-protein mannosyltransferase | dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase | |
| 2.4.1.11 | glycogen(starch) synthase | UDP-glucose:glycogen 4-alpha-D-glucosyltransferase | |
| 2.4.1.12 | cellulose synthase (UDP-forming) | UDP-glucose:(1->4)-beta-D-glucan 4-beta-D-glucosyltransferase | |
| 2.4.1.122 | N-acetylgalactosaminide beta-1,3-galactosyltransferase | UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting) | |
| 2.4.1.135 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase | UDP-alpha-D-glucuronate:[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine D-glucuronosyltransferase (configuration-inverting) | |
| 2.4.1.141 | N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase | UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase | |
| 2.4.1.143 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-(1->6)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | |
| 2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)-beta-D-mannosyl-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | |
| 2.4.1.17 | glucuronosyltransferase | UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) | |
| 2.4.1.186 | glycogenin glucosyltransferase | UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase | |
| 2.4.1.22 | lactose synthase | UDP-galactose:D-glucose 4-beta-D-galactosyltransferase | |
| 2.4.1.222 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | |
| 2.4.1.224 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase | UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase | |
| 2.4.1.225 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase | UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase | |
| 2.4.1.275 | neolactotriaosylceramide beta-1,4-galactosyltransferase | UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1beta4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase | |
| 2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase | UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase | |
| 2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase | UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase | |
| 2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase | GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase | |
| 2.4.1.83 | dolichyl-phosphate beta-D-mannosyltransferase | GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase | |
| 2.4.1.90 | N-acetyllactosamine synthase | UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase | |
| 2.4.2.1 | purine-nucleoside phosphorylase | purine-nucleoside:phosphate ribosyltransferase | |
| 2.4.2.30 | NAD+ ADP-ribosyltransferase | NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase | |
| 2.4.2.36 | NAD+-diphthamide ADP-ribosyltransferase | NAD+:diphthamide-[translation elongation factor 2] N-(ADP-D-ribosyl)transferase | |
| 2.4.2.7 | adenine phosphoribosyltransferase | AMP:diphosphate phospho-D-ribosyltransferase | |
| 2.4.2.8 | hypoxanthine phosphoribosyltransferase | IMP:diphosphate phospho-D-ribosyltransferase | |
| 2.4.99.28 | peptidoglycan glycosyltransferase | [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase | |
| 2.5.1.151 | alkylcobalamin dealkylase | methylcobalamin:glutathione S-methyltransferase | |
| 2.5.1.58 | protein farnesyltransferase | farnesyl-diphosphate:protein-cysteine farnesyltransferase | |
| 2.5.1.59 | protein geranylgeranyltransferase type I | geranylgeranyl-diphosphate:protein-cysteine geranyltransferase | |
| 2.5.1.87 | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10–55 isopentenyl units) | |
| 2.7.1.1 | hexokinase | ATP:D-hexose 6-phosphotransferase | |
| 2.7.1.107 | diacylglycerol kinase (ATP) | ATP:1,2-diacyl-sn-glycerol 3-phosphotransferase | |
| 2.7.1.137 | phosphatidylinositol 3-kinase | ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase | |
| 2.7.1.138 | ceramide kinase | ATP:ceramide 1-phosphotransferase | |
| 2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | |
| 2.7.1.25 | adenylyl-sulfate kinase | ATP:adenylyl-sulfate 3'-phosphotransferase | |
| 2.7.1.28 | triokinase | ATP:D-glyceraldehyde 3-phosphotransferase | |
| 2.7.1.29 | glycerone kinase | ATP:glycerone phosphotransferase | |
| 2.7.1.3 | ketohexokinase | ATP:D-fructose 1-phosphotransferase | |
| 2.7.1.94 | acylglycerol kinase | ATP:acylglycerol 3-phosphotransferase | |
| 2.7.10.1 | receptor protein-tyrosine kinase | ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) | |
| 2.7.10.2 | non-specific protein-tyrosine kinase | ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 2.7.11.10 | IkappaB kinase | ATP:[IkappaB protein] phosphotransferase | |
| 2.7.11.22 | cyclin-dependent kinase | ATP:cyclin phosphotransferase | |
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | ATP:[DNA-directed RNA polymerase] phosphotransferase | |
| 2.7.11.24 | mitogen-activated protein kinase | ATP:protein phosphotransferase (MAPKK-activated) | |
| 2.7.11.25 | mitogen-activated protein kinase kinase kinase | ATP:protein phosphotransferase (MAPKKKK-activated) | |
| 2.7.11.26 | tau-protein kinase | ATP:[tau-protein] O-phosphotransferase | |
| 2.7.11.30 | receptor protein serine/threonine kinase | ATP:[receptor-protein] phosphotransferase | |
| 2.7.11.4 | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase | ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase | |
| 2.7.12.2 | mitogen-activated protein kinase kinase | ATP:protein phosphotransferase (MAPKKK-activated) | |
| 2.7.2.3 | phosphoglycerate kinase | ATP:3-phospho-D-glycerate 1-phosphotransferase | |
| 2.7.4.6 | nucleoside-diphosphate kinase | ATP:nucleoside-diphosphate phosphotransferase | |
| 2.7.7.102 | DNA primase AEP | (deoxy)nucleotide 5'-triphosphate:single-stranded DNA (deoxy)nucleotidyltransferase (DNA or DNA-RNA hybrid synthesizing) | |
| 2.7.7.19 | polynucleotide adenylyltransferase | ATP:polynucleotide adenylyltransferase | |
| 2.7.7.4 | sulfate adenylyltransferase | ATP:sulfate adenylyltransferase | |
| 2.7.7.48 | RNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed) | |
| 2.7.7.49 | RNA-directed DNA polymerase | deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) | |
| 2.7.7.50 | mRNA guanylyltransferase | GTP:mRNA guanylyltransferase | |
| 2.7.7.6 | DNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) | |
| 2.7.7.7 | DNA-directed DNA polymerase | deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | |
| 2.7.7.84 | 2'-5' oligoadenylate synthase | ATP:ATP adenylyltransferase (2'-5' linkages-forming) | |
| 2.7.7.86 | cyclic GMP-AMP synthase | ATP:GTP adenylyltransferase (cyclizing) | |
| 2.7.7.88 | GDP polyribonucleotidyltransferase | (5')pppAACA-[mRNA]:GDP 5'-phosphopolyribonucleotidyltransferase [(5')pppAACA-[mRNA]-forming] | |
| 3.1.1.108 | iron(III)-enterobactin esterase | iron(III)-enterobactin hydrolase | |
| 3.1.13.2 | exoribonuclease H | ||
| 3.1.2.14 | oleoyl-[acyl-carrier-protein] hydrolase | oleoyl-[acyl-carrier protein] hydrolase | |
| 3.1.2.2 | palmitoyl-CoA hydrolase | palmitoyl-CoA hydrolase | |
| 3.1.26.13 | retroviral ribonuclease H | ||
| 3.1.3.16 | protein-serine/threonine phosphatase | protein-serine/threonine-phosphate phosphohydrolase | |
| 3.1.3.2 | acid phosphatase | phosphate-monoester phosphohydrolase (acid optimum) | |
| 3.1.3.35 | thymidylate 5'-phosphatase | thymidylate 5'-phosphohydrolase | |
| 3.1.3.48 | protein-tyrosine-phosphatase | protein-tyrosine-phosphate phosphohydrolase | |
| 3.1.3.5 | 5'-nucleotidase | 5'-ribonucleotide phosphohydrolase | |
| 3.1.3.52 | [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase | [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphate phosphohydrolase | |
| 3.1.3.53 | [myosin-light-chain] phosphatase | [myosin-light-chain]-phosphate phosphohydrolase | |
| 3.1.3.64 | phosphatidylinositol-3-phosphatase | 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase | |
| 3.1.3.89 | 5'-deoxynucleotidase | 2'-deoxyribonucleoside 5'-monophosphate phosphohydrolase | |
| 3.1.3.91 | 7-methylguanosine nucleotidase | N7-methyl-GMP phosphohydrolase | |
| 3.1.3.99 | IMP-specific 5'-nucleotidase | inosine 5'-phosphate phosphohydrolase | |
| 3.1.31.1 | micrococcal nuclease | ||
| 3.1.4.11 | phosphoinositide phospholipase C | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase | |
| 3.1.4.54 | N-acetylphosphatidylethanolamine-hydrolysing phospholipase D | N-acetylphosphatidylethanolamine phosphatidohydrolase | |
| 3.2.1.106 | mannosyl-oligosaccharide glucosidase | Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting) | |
| 3.2.1.108 | lactase | lactose galactohydrolase (configuration-retaining) | |
| 3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase | (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining) | |
| 3.2.1.18 | exo-alpha-sialidase | acetylneuraminyl hydrolase | |
| 3.2.1.23 | beta-galactosidase | beta-D-galactoside galactohydrolase | |
| 3.2.1.52 | beta-N-acetylhexosaminidase | beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase | |
| 3.2.1.62 | glycosylceramidase | beta-D-glucosyl-N-acylsphingosine glycohydrolase (configuration-retaining) | |
| 3.2.2.27 | uracil-DNA glycosylase | uracil-DNA deoxyribohydrolase (uracil-releasing) | |
| 3.2.2.5 | NAD+ glycohydrolase | NAD+ glycohydrolase | |
| 3.2.2.6 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | NAD+ glycohydrolase (cyclic ADP-ribose-forming) | |
| 3.4.13.19 | membrane dipeptidase | ||
| 3.4.16.4 | serine-type D-Ala-D-Ala carboxypeptidase | ||
| 3.4.16.5 | carboxypeptidase C | ||
| 3.4.17.23 | angiotensin-converting enzyme 2 | ||
| 3.4.19.12 | ubiquitinyl hydrolase 1 | ||
| 3.4.19.13 | glutathione gamma-glutamate hydrolase | ||
| 3.4.19.14 | leukotriene-C4 hydrolase | ||
| 3.4.21.122 | transmembrane protease serine 2 | ||
| 3.4.21.20 | cathepsin G | ||
| 3.4.21.22 | coagulation factor IXa | ||
| 3.4.21.27 | coagulation factor XIa | ||
| 3.4.21.34 | plasma kallikrein | ||
| 3.4.21.38 | coagulation factor XIIa | ||
| 3.4.21.42 | complement subcomponent C1s | ||
| 3.4.21.5 | thrombin | ||
| 3.4.21.6 | coagulation factor Xa | ||
| 3.4.21.75 | Furin | ||
| 3.4.21.79 | granzyme B | ||
| 3.4.21.89 | Signal peptidase I | ||
| 3.4.21.91 | Flavivirin | ||
| 3.4.21.97 | assemblin | ||
| 3.4.22.15 | cathepsin L | ||
| 3.4.22.36 | caspase-1 | ||
| 3.4.22.52 | calpain-1 | ||
| 3.4.22.53 | calpain-2 | ||
| 3.4.22.57 | caspase-4 | ||
| 3.4.22.61 | caspase-8 | ||
| 3.4.22.62 | caspase-9 | ||
| 3.4.22.69 | SARS coronavirus main proteinase | ||
| 3.4.23.16 | HIV-1 retropepsin | ||
| 3.4.24.35 | gelatinase B | ||
| 3.4.24.68 | tentoxilysin | ||
| 3.4.24.69 | bontoxilysin | ||
| 3.4.24.83 | anthrax lethal factor endopeptidase | ||
| 3.4.24.86 | ADAM 17 endopeptidase | ||
| 3.4.24.87 | ADAMTS13 endopeptidase | ||
| 3.5.1.98 | histone deacetylase | histone amidohydrolase | |
| 3.5.2.6 | beta-lactamase | beta-lactam hydrolase | |
| 3.5.4.10 | IMP cyclohydrolase | IMP 1,2-hydrolase (decyclizing) | |
| 3.6.1.15 | nucleoside-triphosphate phosphatase | unspecific diphosphate phosphohydrolase | |
| 3.6.1.23 | dUTP diphosphatase | dUTP nucleotidohydrolase | |
| 3.6.1.5 | apyrase | nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming) | |
| 3.6.1.6 | nucleoside diphosphate phosphatase | nucleoside-diphosphate phosphohydrolase | |
| 3.6.1.74 | mRNA 5'-phosphatase | 5'-triphospho-mRNA 5'-phosphohydrolase | |
| 3.6.4.10 | non-chaperonin molecular chaperone ATPase | ATP phosphohydrolase (polypeptide-polymerizing) | |
| 3.6.4.12 | DNA helicase | ||
| 3.6.4.13 | RNA helicase | ||
| 3.6.4.6 | vesicle-fusing ATPase | ATP phosphohydrolase (vesicle-fusing) | |
| 3.6.5.2 | small monomeric GTPase | GTP phosphohydrolase (cell-regulating) | |
| 3.6.5.3 | protein-synthesizing GTPase | GTP phosphohydrolase (mRNA-translation-assisting) | |
| 4.1.1.90 | peptidyl-glutamate 4-carboxylase | peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing) | |
| 4.1.2.13 | fructose-bisphosphate aldolase | D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming) | |
| 4.2.1.11 | phosphopyruvate hydratase | 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming) | |
| 4.2.1.59 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase | (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming) | |
| 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase | |
| 4.6.1.1 | adenylate cyclase | ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) | |
| 4.6.1.15 | FAD-AMP lyase (cyclizing) | FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) | |
| 4.6.1.2 | guanylate cyclase | GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) | |
| 4.98.1.1 | protoporphyrin ferrochelatase | protoheme ferro-lyase (protoporphyrin-forming) | |
| 5.1.3.2 | UDP-glucose 4-epimerase | UDP-glucose 4-epimerase | |
| 5.1.3.7 | UDP-N-acetylglucosamine 4-epimerase | UDP-N-acetyl-D-glucosamine 4-epimerase | |
| 5.2.1.8 | peptidylprolyl isomerase | Peptidylproline cis-trans-isomerase | |
| 5.3.1.6 | ribose-5-phosphate isomerase | D-ribose-5-phosphate aldose-ketose-isomerase | |
| 5.3.4.1 | protein disulfide-isomerase | Protein disulfide-isomerase | |
| 5.3.99.3 | prostaglandin-E synthase | (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase | |
| 5.4.99.2 | methylmalonyl-CoA mutase | (R)-methylmalonyl-CoA CoA-carbonylmutase | |
| 5.6.1.6 | channel-conductance-controlling ATPase | ATP phosphohydrolase (channel-conductance-controlling) | |
| 5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) | DNA topoisomerase (ATP-hydrolysing) | |
| 5.6.2.3 | DNA 5'-3' helicase | DNA 5'-3' helicase (ATP-hydrolysing) | |
| 5.6.2.4 | DNA 3'-5' helicase | DNA 3'-5' helicase (ATP-hydrolysing) | |
| 6.1.1.16 | cysteine-tRNA ligase | L-cysteine:tRNACys ligase (AMP-forming) | |
| 6.4.1.1 | pyruvate carboxylase | pyruvate:carbon-dioxide ligase (ADP-forming) | |
| 6.4.1.2 | acetyl-CoA carboxylase | acetyl-CoA:hydrogencarbonate ligase (ADP-forming) | |
| 6.4.1.3 | propionyl-CoA carboxylase | propanoyl-CoA:carbon-dioxide ligase (ADP-forming) | |
| 6.4.1.4 | methylcrotonoyl-CoA carboxylase | 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) | |
| 6.5.1.1 | DNA ligase (ATP) | poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP) | |
| 7.2.2.16 | ABC-type ferric hydroxamate transporter | ATP phosphohydrolase [ABC-type, iron(III) hydroxamate-importing] | |
| 7.2.2.17 | ABC-type ferric enterobactin transporter | ATP phosphohydrolase (ABC-type, iron(III) enterobactin-importing) | |
| 7.2.2.18 | ABC-type ferric citrate transporter | ATP phosphohydrolase (ABC-type, iron(III) dicitrate-importing) | |
| 7.2.2.20 | ABC-type Zn2+ transporter | ATP phosphohydrolase (ABC-type, Zn2+-importing) | |
| 7.4.2.6 | ABC-type oligopeptide transporter | ATP phosphohydrolase (ABC-type, oligopeptide-importing) | |
| 7.4.2.8 | protein-secreting ATPase | ATP phosphohydrolase (protein-secreting) | |
| 7.4.2.9 | ABC-type dipeptide transporter | ATP phosphohydrolase (ABC-type, dipeptide-transporting) | |
| 7.6.2.3 | ABC-type glutathione-S-conjugate transporter | ATP + H2O + glutathione-S-conjugate[side 1] = ADP + phosphate + glutathione-S-conjugate[side 2] | |
| 7.6.2.8 | ABC-type vitamin B12 transporter | ATP phosphohydrolase (ABC-type, vitamin B12-importing) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| A0A0H2US87 | ospC3 | Arginine ADP-riboxanase OspC3 |
| O05442 | Rv3903c | Hypothetical alanine and proline rich protein |
| O53361 | sapM | Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) |
| O88093 | hbp | Hemoglobin-binding protease hbp autotransporter |
| P00803 | lepB | Signal peptidase I |
| P02919 | mrcB | Penicillin-binding protein 1B |
| P04958 | tetX | tetanus toxin tetX |
| P07821 | fhuC | Iron(3+)-hydroxamate import ATP-binding protein FhuC |
| P0A3M3 | bla | Beta-lactamase OXA-9 |
| P0A9X1 | znuC | Zinc import ATP-binding protein ZnuC |
| P0AAG0 | dppD | Dipeptide transport ATP-binding protein DppD |
| P0AES4 | gyrA | DNA gyrase subunit A |
| P0AES6 | gyrB | DNA gyrase subunit B |
| P0DPI0 | botA | Botulinum neurotoxin type A |
| P10408 | secA | Protein translocase subunit SecA |
| P10844 | botB | Botulinum neurotoxin type B |
| P13039 | fes | Iron(III) enterobactin esterase |
| P15031 | fecE | Fe(3+) dicitrate transport ATP-binding protein FecE |
| P15917 | lef | Lethal factor |
| P23878 | fepC | Ferric enterobactin transport ATP-binding protein FepC |
| P30996 | botF | Botulinum neurotoxin type F |
| P37313 | dppF | Dipeptide transport ATP-binding protein DppF |
| P37653 | bcsA | Cellulose synthase catalytic subunit [UDP-forming] |
| P40136 | cya | Calmodulin-sensitive adenylate cyclase |
| P62593 | bla | Beta-lactamase TEM |
| P75831 | macB | Macrolide export ATP-binding/permease protein MacB |
| P9WFK7 | eis | N-acetyltransferase Eis |
| P9WG35 | tpx | Thiol peroxidase |
| P9WGE7 | sodB | Superoxide dismutase [Fe] |
| P9WGE9 | sodC | Superoxide dismutase [Cu-Zn] |
| P9WGP3 | secA2 | Protein translocase subunit SecA 2 |
| P9WGP5 | secA1 | Protein translocase subunit SecA 1 |
| P9WGY5 | rpoZ | DNA-directed RNA polymerase subunit omega |
| P9WGY7 | rpoC | DNA-directed RNA polymerase subunit beta' |
| P9WGY9 | rpoB | DNA-directed RNA polymerase subunit beta |
| P9WGZ1 | rpoA | DNA-directed RNA polymerase subunit alpha |
| P9WHH1 | trxB | Thioredoxin reductase |
| P9WHH9 | lpdC | Dihydrolipoyl dehydrogenase |
| P9WIA1 | ptpA | Low molecular weight protein-tyrosine phosphatase A |
| P9WIE3 | ahpE | Alkyl hydroperoxide reductase E |
| P9WIE5 | katG | Catalase-peroxidase |
| P9WIS7 | dlaT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
| P9WJH7 | ndkA | Nucleoside diphosphate kinase |
| P9WNE1 | fgd1 | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| P9WNE5 | bfrB | Bacterioferritin BfrB |
| P9WPQ9 | bfr | Bacterioferritin BfrA |
| P9WQB5 | ahpD | Alkyl hydroperoxide reductase AhpD |
| P9WQB7 | ahpC | Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) |
| P9WQJ5 | oppD | Oligopeptide transport ATP-binding protein OppD |
| P9WQJ7 | irtB | Mycobactin import ATP-binding/permease protein IrtB |
| P9WQJ9 | irtA | Mycobactin import ATP-binding/permease protein IrtA |
| Q00496 | botE | Botulinum neurotoxin type E |
| Q46871 | yqjH | NADPH-dependent ferric-chelate reductase |
| Q60393 | botG | Botulinum neurotoxin type G |
| Q8VSC3 | ipaH9.8 | E3 ubiquitin-protein ligase ipaH9.8 |
| Q8XAS4 | efeB | Deferrochelatase |
| Q9EZE7 | espC | Serine protease EspC |
| Q9F663 | KPC-2 | Carbapenem-hydrolyzing beta-lactamase KPC-2 |