dlaT - Mycobacterium tuberculosis H37Rv
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
> dlaT - Mycobacterium tuberculosis H37Rv [Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex]
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Metadata
Organism Source: 83332 - Mycobacterium tuberculosis H37Rv
EC Number: 2.3.1.12
Cluster:
Registry Model:
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R02569 | acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase | pyruvate dehydrogenase complex:dihydrolipoyllysine-residue acetyltransferase |
| BioCyc:DIHYDLIPACETRANS-RXN | ACETYL-COA + DIHYDROLIPOAMIDE --> CO-A + S-ACETYLDIHYDROLIPOAMIDE | Note: Dihydrolipoamide is used to substitute for dihydrolipoate in assays conducted in vitro, and S-acetyldihydrolipoamide is used to substitute for S-acetyldihydrolipoate in vitro. |
| BioCyc:RXN0-1133 | CO-A + Pyruvate-dehydrogenase-acetylDHlipoyl --> ACETYL-COA + Pyruvate-dehydrogenase-dihydrolipoate | |
| Rhea:RHEA:17018 | N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA => N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA | |
| Rhea:RHEA:17019 | N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA => N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA | |
| Rhea:RHEA:17020 | N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA <=> N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA | |
| Rhea:RHEA:33152 | (R)-dihydrolipoamide + acetyl-CoA => (R)-S6-acetyldihydrolipoamide + CoA | |
| Rhea:RHEA:33153 | (R)-S6-acetyldihydrolipoamide + CoA => (R)-dihydrolipoamide + acetyl-CoA | |
| Rhea:RHEA:33154 | (R)-dihydrolipoamide + acetyl-CoA <=> (R)-S6-acetyldihydrolipoamide + CoA |
Pathways
| pathway id | name |
|---|---|
| BioCyc:MTBH37RV_PYRUVDEHYD-PWY | pyruvate decarboxylation to acetyl CoA |
| BioCyc:MTBH37RV_PWY-5482 | pyruvate fermentation to acetate II |
| Reactome:R-HSA-9635486 | Infection with Mycobacterium tuberculosis |
| Reactome:R-HSA-9824439 | Bacterial Infection Pathways |
| Reactome:R-HSA-1643685 | Disease |
| Reactome:R-HSA-1222499 | Latent infection - Other responses of Mtb to phagocytosis |
| Reactome:R-HSA-5663205 | Infectious disease |
| Reactome:R-HSA-1222541 | Cell redox homeostasis |