EC: 3.4.22.36

caspase-1 ()

enzyme lambda metabolic reaction experiment
uniprot:P29466 [caspase-1(Enzyme) wildtype]

H2O + Succinyl_YVAD_7_amino_4_methylcoumarin -> Succinyl_YVAD + 7_Amino_4_methylcoumarin		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 1 % Chaps, 10 mM dithiothreitol
PH: 7.5
Temperature: 37
uniprot:P29466 [caspase-1(Enzyme) wildtype]

H2O + Succinyl_YVAD_p_nitroanilide -> Succinyl_YVAD + 4_Nitroaniline		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 1 % Chaps, 10 mM dithiothreitol
PH: 7.5
Temperature: 37

Pathways

pathway id name
Reactome:R-HSA-9660826 Purinergic signaling in leishmaniasis infection
Reactome:R-HSA-9679506 SARS-CoV Infections
Reactome:R-MMU-5620971 Pyroptosis
Reactome:R-HSA-5620971 Pyroptosis
Reactome:R-HSA-9692914 SARS-CoV-1-host interactions
Reactome:R-HSA-9664424 Cell recruitment (pro-inflammatory response)
Reactome:R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses
Reactome:R-HSA-9658195 Leishmania infection
Reactome:R-HSA-9678108 SARS-CoV-1 Infection
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-RNO-5620971 Pyroptosis
Reactome:R-HSA-9824443 Parasitic Infection Pathways
Reactome:R-RNO-9953170 GBP-mediated host defense
Reactome:R-DRE-9960519 CASP4-mediated substrate cleavage
Reactome:R-DRE-9686114 Activation of inflammatory caspases
Reactome:R-HSA-9953170 GBP-mediated host defense
Reactome:R-RNO-9968551 Regulation of GBP-mediated host defense
Reactome:R-DRE-9948001 CASP4 inflammasome assembly
Reactome:R-HSA-9968551 Regulation of GBP-mediated host defense
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-844623 The IPAF inflammasome
Reactome:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-HSA-446652 Interleukin-1 family signaling
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-449147 Signaling by Interleukins
Reactome:R-MMU-5357801 Programmed Cell Death
Reactome:R-RNO-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-RNO-446652 Interleukin-1 family signaling
Reactome:R-DRE-168256 Immune System
Reactome:R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
Reactome:R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome:R-HSA-913531 Interferon Signaling
Reactome:R-HSA-449147 Signaling by Interleukins
Reactome:R-MMU-1280215 Cytokine Signaling in Immune system
Reactome:R-RNO-5218859 Regulated Necrosis
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-913531 Interferon Signaling
Reactome:R-RNO-449147 Signaling by Interleukins
Reactome:R-HSA-5357801 Programmed Cell Death
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-3700989 Transcriptional Regulation by TP53
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-622312 Inflammasomes
Reactome:R-HSA-844615 The AIM2 inflammasome
Reactome:R-HSA-448706 Interleukin-1 processing
Reactome:R-MMU-446652 Interleukin-1 family signaling
Reactome:R-RNO-5357801 Programmed Cell Death
Reactome:R-RNO-448706 Interleukin-1 processing
Reactome:R-DRE-168249 Innate Immune System
Reactome:R-HSA-5218859 Regulated Necrosis
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome:R-HSA-844456 The NLRP3 inflammasome
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-9008059 Interleukin-37 signaling
Reactome:R-MMU-448706 Interleukin-1 processing
Reactome:R-MMU-5218859 Regulated Necrosis
Reactome:R-RNO-1280215 Cytokine Signaling in Immune system
PathBank:SMP0120910 D4-GDI Signaling Pathway
PathBank:SMP0120958 D4-GDI Signaling Pathway
PathBank:SMP0066935 D4-GDI Signaling Pathway