EC: 1.8.1.4

dihydrolipoyl dehydrogenase (protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:Q3A7N7 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

H+ + NADH + Lipoamide -> NAD+ + Dihydrolipoamide		 (( (Vmax * A) ) / (Km + A)) buffer: 90 mM Potassium phosphate, 2 mM EDTA
PH: 7.2
Temperature: 30
uniprot:Q3A7N7 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

Lipoamide + H+ + NADH -> NAD+ + Dihydrolipoamide		 (( (Vmax * A) ) / (Km + A)) buffer: 90 mM Potassium phosphate, 2 mM EDTA
PH: 7.2
Temperature: 30
uniprot:Q3A7N7 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

Dihydrolipoamide + NAD+ -> H+ + NADH + Lipoamide		 (( (Vmax * A) ) / (Km + A)) buffer: 90 mM Potassium phosphate, 2 mM EDTA
PH: 7.2
Temperature: 30
uniprot:Q3A7N7 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NAD+ + Dihydrolipoamide -> Lipoamide + H+ + NADH		 (( (Vmax * A) ) / (Km + A)) buffer: 90 mM Potassium phosphate, 2 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P31023 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NAD+ + Dihydrolipoamide -> NADH + Lipoamide + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mm Mops, 8 mm TCEP
PH: 7.5
Temperature: 30
uniprot:P31023 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

N_alpha_(D,L_1,2_dithiolane_3_pentanoyl)_N_[Tris(hydroxymethyl)methyl]_glycinamide + NAD+ -> NADH + Oxidized_N_alpha_(D,L_1,2_dithiolane_3_pentanoyl)_N_[Tris(hydroxymethyl)methyl]_glycinamide + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mm Mops, 8 mm TCEP
PH: 7.5
Temperature: 30
uniprot:P31023 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

N_alpha_(benzyloxycarbonyl)_N_omega_(D,L_1,2_dithiolane_3_pentanoyl)_L_lysine + NAD+ -> H+ + Oxidized_N_alpha_(benzyloxycarbonyl)_N_omega_(D,L_1,2_dithiolane_3_pentanoyl)_L_lysine + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mm Mops, 8 mm TCEP
PH: 7.5
Temperature: 30
uniprot:P31023 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

N_gamma_(D,L_1,2_dithiolane_3_pentanoyl)_N_[Tris(hydroxymethyl)methyl]_butanamide + NAD+ -> NADH + H+ + Oxidized_N_alpha_(D,L_1,2_dithiolane_3_pentanoyl)_N_[Tris(hydroxymethyl)methyl]_butanamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mm Mops, 8 mm TCEP
PH: 7.5
Temperature: 30
uniprot:P31023 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

N_gamma_(D_1,2_dithiolane_3_pentanoyl)_N_[Tris(hydroxymethyl)methyl]_butanamide + NAD+ -> NADH + H+ + Oxidized_N_alpha_(D_1,2_dithiolane_3_pentanoyl)_N_[Tris(hydroxymethyl)methyl]_butanamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mm Mops, 8 mm TCEP
PH: 7.5
Temperature: 30
uniprot:P31023 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

Dihydrolipoylprotein + NAD+ -> H+ + Lipoylprotein + NADH		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Mops, 8 mM TCEP
PH: 7.5
Temperature: 30
uniprot:Q04829 [K+]

NAD+ + Dihydrolipoamide -> NADH + H+ + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423D]

NAD+ + Dihydrolipoamide -> H+ + NADH + Lipoamide		 (Vmax / (( (1 + (Km / S)) ) + (S / Ki))) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423D]

Dihydrolipoamide + NAD+ -> NADH + H+ + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NAD+ + Dihydrolipoamide -> Lipoamide + NADH + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423Q]

Dihydrolipoamide + NAD+ -> H+ + NADH + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423S]

NAD+ + Dihydrolipoamide -> H+ + NADH + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NAD+ + Dihydrolipoamide -> H+ + Lipoamide + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423A]

Dihydrolipoamide + NAD+ -> NADH + H+ + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423Q]

Dihydrolipoamide + NAD+ -> Lipoamide + H+ + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423S]

Dihydrolipoamide + NAD+ -> NADH + H+ + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [dihydrolipoyl dehydrogenase(Enzyme) mutant E423A]

Dihydrolipoamide + NAD+ -> NADH + Lipoamide + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

NAD+ + Dihydrolipoamide -> NADH + H+ + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

NAD+ + Dihydrolipoamide -> NADH + H+ + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

NAD+ + Dihydrolipoamide -> Lipoamide + H+ + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

Dihydrolipoamide + NAD+ -> Lipoamide + NADH + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

NAD+ + Dihydrolipoamide -> H+ + NADH + Lipoamide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

Dihydrolipoamide + NAD+ -> H+ + Lipoamide + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

Dihydrolipoamide + NAD+ -> Lipoamide + NADH + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

NAD+ + Dihydrolipoamide -> Lipoamide + H+ + NADH		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q04829 [K+]

NAD+ + Dihydrolipoamide -> Lipoamide + NADH + H+		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM potassium phosphate
PH: 7
Temperature: 30
uniprot:Q6P6R2 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NAD+ + Dihydrolipoamide -> Lipoamide + NADH		 (1 / (( (( (( (( (Ka / V) ) * (( (1 + (( (Q / Kiq) ) * (1 + (Kib / B)))) ) + (( (Kib * (Q ^ 2)) ) / (( (Kiq * KIq) ) * B)))) ) * 1) ) / A) ) + (( (1 / V) ) * (1 + (( (Kb / B) ) * (1 + (Q / KIq))))))) buffer: 0.1 M Potassium phosphate, 1.0 mM EDTA
PH: 8
Temperature: 37
uniprot:Q6P6R2 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NAD+ + Dihydrolipoamide -> Lipoamide + NADH		 (( (( (V * A) ) * B) ) / (( (( (Ka * B) ) + (Kb * A)) ) + (A * B))) buffer: 0.1 M Potassium phosphate, 1.0 mM EDTA
PH: 8
Temperature: 37
uniprot:Q6P6R2 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

Lipoamide + NADH -> Dihydrolipoamide + NAD+		 (( (( (V * A) ) * B) ) / (( (( (Ka * B) ) + (Kb * A)) ) + (A * B))) buffer: 0.1 M Potassium phosphate, 1.0 mM EDTA
PH: 8
Temperature: 37
uniprot:Q6P6R2 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NAD+ + Dihydrolipoamide -> NADH + Lipoamide		 (1 / (( (( (( (( (Kb / V) ) * (( (1 + (Q * (( (1 / KIq) ) + (( (Ka * Kib) ) / (( (Kiq * Kb) ) * A))))) ) + (( (( (Ka * Kib) ) * (Q ^ 2)) ) / (( (( (Kb * Kiq) ) * KIq) ) * A)))) ) * 1) ) / B) ) + (( (1 / V) ) * (1 + (( (Ka / A) ) * (1 + (Q / Kiq))))))) buffer: 0.1 M Potassium phosphate, 1.0 mM EDTA
PH: 8
Temperature: 37
uniprot:Q835M1 [dihydrolipoyl dehydrogenase(Enzyme) wildtype E3]

Dihydrolipoamide + NAD+ -> Lipoamide + NADH		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM sodium pyrophosphate, 0.5 mM EDTA
PH: 8
Temperature: 25
uniprot:P85207 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

3 NADH + H+ + Cr(VI) -> Cr(III) + 3 NAD+		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM MOPS-NaOH, 5 mM EDTA
PH: 6.5
Temperature: 65
uniprot:P85207 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

3 NADH + Cr(VI) + H+ -> Cr(III) + 3 NAD+		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM MOPS-NaOH, 5 mM EDTA
PH: 6.5
Temperature: 65
uniprot:Q93T20 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

H+ + 3 NADH + Cr(VI) -> Cr(III) + 3 NAD+		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Citric acid-NaOH
PH: 5
Temperature: 50
uniprot:P09622 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NADH + H+ + Lipoamide -> NAD+ + Dihydrolipoamide		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Potassium phosphate, 1.25 mM EDTA
PH: 6
Temperature: 25
uniprot:P09622 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

Dihydrolipoamide + NAD+ -> H+ + NADH + Lipoamide		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Potassium phosphate, 1.25 mM EDTA
PH: 8.5
Temperature: 25
uniprot:P09622 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

NADH + H+ + Lipoate -> Dihydrolipoate + NAD+		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Potassium phosphate, 1.25 mM EDTA
PH: 6
Temperature: 25
uniprot:P09622 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

Nepsilon_Lipoyllysine + H+ + NADH -> Nepsilon_Dihydrolipoyllysine + NAD+		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Potassium phosphate, 1.25 mM EDTA
PH: 6
Temperature: 25
uniprot:P09622 [dihydrolipoyl dehydrogenase(Enzyme) wildtype]

Nepsilon_Dihydrolipoyllysine + NAD+ -> H+ + Nepsilon_Lipoyllysine + NADH		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 50 mM Potassium phosphate, 1.25 mM EDTA
PH: 8.5
Temperature: 25

Pathways

pathway id name
BioCyc:HUMAN_ILEUDEG-PWY isoleucine degradation
BioCyc:HUMAN_PWY-5328 superpathway of methionine degradation
BioCyc:META_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:META_PWY-2201 folate transformations I
BioCyc:META_GLYCLEAV-PWY glycine cleavage
BioCyc:META_ILEUDEG-PWY L-isoleucine degradation I
BioCyc:META_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:META_PWY-5328 superpathway of L-methionine salvage and degradation
BioCyc:ECO_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA
BioCyc:ECO_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:YEAST_GLYCLEAV-PWY glycine cleavage
BioCyc:YEAST_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:ARA_VALDEG-PWY L-valine degradation I
BioCyc:VCHO_PWY-5690 TCA cycle II (plants and fungi)
BioCyc:VCHO_PWY-3841 folate transformations II
BioCyc:VCHO_P41-PWY pyruvate fermentation to acetate and lactate I
BioCyc:VCHO_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBH37RV_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBH37RV_PWY-5482 pyruvate fermentation to acetate II
BioCyc:MTBH37RV_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
BioCyc:MTBCDC1551_GLYCLEAV-PWY glycine cleavage
BioCyc:MTBCDC1551_ILEUDEG-PWY L-isoleucine degradation I
BioCyc:MTBCDC1551_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:MTBCDC1551_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
BioCyc:ECOO157_TCA TCA cycle I (prokaryotic)
BioCyc:ECOO157_P41-PWY pyruvate fermentation to acetate and lactate I
BioCyc:ECOO157_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:BSUB_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA
BioCyc:BSUB_GLYCLEAV-PWY glycine cleavage
BioCyc:ECOL316407_TCA TCA cycle I (prokaryotic)
BioCyc:ECOL316407_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:CORYNE_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA
BioCyc:HUMAN_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
BioCyc:HUMAN_LEU-DEG2-PWY leucine degradation
BioCyc:META_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
BioCyc:META_PWY-5482 pyruvate fermentation to acetate II
BioCyc:META_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:META_TCA TCA cycle I (prokaryotic)
BioCyc:META_PWY-5130 2-oxobutanoate degradation I
BioCyc:META_PWY66-428 L-threonine degradation V
BioCyc:META_VALDEG-PWY L-valine degradation I
BioCyc:ECO_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:YEAST_PWY3O-697 folate interconversions
BioCyc:ARA_LEU-DEG2-PWY L-leucine degradation I
BioCyc:ARA_ILEUDEG-PWY L-isoleucine degradation I
BioCyc:VCHO_TCA TCA cycle I (prokaryotic)
BioCyc:VCHO_PWY-2201 folate transformations I
BioCyc:VCHO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:ECOO157_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:MOUSE_PWY3DJ-6 Leucine Catabolism
BioCyc:MOUSE_GLYCLEAV-PWY glycine cleavage complex
BioCyc:MOUSE_PYRUVDEHYD-PWY acetyl-CoA biosynthesis (from pyruvate)
BioCyc:BSUB_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:ECOL316407_ANARESP1-PWY respiration (anaerobic)
BioCyc:CORYNE_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:HUMAN_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA
BioCyc:HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
BioCyc:HUMAN_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:HUMAN_PWY66-428 threonine degradation
BioCyc:HUMAN_VALDEG-PWY valine degradation
BioCyc:META_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA
BioCyc:META_P41-PWY pyruvate fermentation to acetate and lactate I
BioCyc:META_PWY-7218 photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
BioCyc:ECO_TCA TCA cycle I (prokaryotic)
BioCyc:ECO_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:ECO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:ARA_GLYCLEAV-PWY glycine cleavage
BioCyc:VCHO_VALDEG-PWY L-valine degradation I
BioCyc:VCHO_PWY-5482 pyruvate fermentation to acetate II
BioCyc:VCHO_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:MTBH37RV_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:MTBH37RV_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA
BioCyc:MTBCDC1551_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBCDC1551_PWY-5482 pyruvate fermentation to acetate II
BioCyc:MTBCDC1551_VALDEG-PWY L-valine degradation I
BioCyc:ECOO157_PWY-2201 folate transformations I
BioCyc:ECOO157_PWY-5482 pyruvate fermentation to acetate II
BioCyc:MOUSE_PWY-5046 branched-chain α-keto acid dehydrogenase complex
BioCyc:MOUSE_PWY-5173 superpathway of acetyl-CoA biosynthesis
BioCyc:MOUSE_PWY3DJ-35778 Serine degradation II
BioCyc:ECOL316407_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:ECOL316407_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA
BioCyc:CORYNE_TCA TCA cycle I (prokaryotic)
BioCyc:HUMAN_PWY-5130 2-oxobutanoate degradation
BioCyc:HUMAN_GLYCLEAV-PWY glycine cleavage
BioCyc:META_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:META_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:META_LEU-DEG2-PWY L-leucine degradation I
BioCyc:ECO_GLYCLEAV-PWY glycine cleavage
BioCyc:YEAST_PWY-2201 folate transformations
BioCyc:YEAST_PWY-5690 TCA cycle II (plants and fungi)
BioCyc:YEAST_PWY-5084 2-ketoglutarate dehydrogenase complex
BioCyc:YEAST_PYRUVDEHYD-PWY pyruvate dehydrogenase complex
BioCyc:ARA_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
BioCyc:VCHO_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:MTBH37RV_VALDEG-PWY L-valine degradation I
BioCyc:MTBH37RV_GLYCLEAV-PWY glycine cleavage
BioCyc:MTBCDC1551_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:ECOO157_ANARESP1-PWY respiration (anaerobic)
BioCyc:ECOO157_1CMET2-PWY formylTHF biosynthesis
BioCyc:ECOO157_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MOUSE_PWY-5084 2-ketoglutarate dehydrogenase complex
BioCyc:BSUB_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
BioCyc:ECOL316407_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:CORYNE_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
WikiPathways:WP2472 Escherichia coli K-12 peripherome
PathBank:SMP0000802 TCA Cycle
PathBank:SMP0001018 TCA cycle (ubiquinol-2)
PathBank:SMP0001019 TCA cycle (ubiquinol-3)
PathBank:SMP0001020 TCA cycle (ubiquinol-4)
PathBank:SMP0001021 TCA cycle (ubiquinol-5)
PathBank:SMP0001022 TCA cycle (ubiquinol-6)
PathBank:SMP0001023 TCA cycle (ubiquinol-7)
PathBank:SMP0001024 TCA cycle (ubiquinol-8)
PathBank:SMP0001025 TCA cycle (ubiquinol-9)
PathBank:SMP0001026 TCA cycle (ubiquinol-10)
PathBank:SMP0002037 TCA cycle (ubiquinol-0)
PathBank:SMP0002095 Pyruvate Decarboxylation to Acetyl-CoA
PathBank:SMP0002120 2-Oxoglutarate Decarboxylation to Succinyl-CoA
PlantCyc:ARA_PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage
PlantCyc:ARA_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I
PlantCyc:ARA_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
PlantCyc:ARA_PWY-7197 pyrimidine deoxyribonucleotide phosphorylation
PlantCyc:ARA_GLYCLEAV-PWY glycine cleavage
PlantCyc:ARA_PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II
PlantCyc:PLANT_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
PlantCyc:ARA_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA
Reactome:R-HSA-9635486 Infection with Mycobacterium tuberculosis
Reactome:R-HSA-9637687 Suppression of phagosomal maturation
Reactome:R-HSA-9637690 Response of Mtb to phagocytosis
Reactome:R-HSA-9636383 Prevention of phagosomal-lysosomal fusion
Reactome:R-HSA-9824439 Bacterial Infection Pathways
Reactome:R-BTA-9853506 Succinyl-CoA Biosynthesis
Reactome:R-CEL-9853506 Succinyl-CoA Biosynthesis
Reactome:R-HSA-9861718 Regulation of pyruvate metabolism
Reactome:R-SPO-9861718 Regulation of pyruvate metabolism
Reactome:R-BTA-9861718 Regulation of pyruvate metabolism
Reactome:R-CEL-9861718 Regulation of pyruvate metabolism
Reactome:R-DDI-9853506 Succinyl-CoA Biosynthesis
Reactome:R-HSA-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-MMU-9853506 Succinyl-CoA Biosynthesis
Reactome:R-RNO-9853506 Succinyl-CoA Biosynthesis
Reactome:R-SCE-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-SPO-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-DDI-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-HSA-9853506 Succinyl-CoA Biosynthesis
Reactome:R-MMU-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-RNO-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-SCE-9853506 Succinyl-CoA Biosynthesis
Reactome:R-SPO-9853506 Succinyl-CoA Biosynthesis
Reactome:R-BTA-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-CEL-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-MMU-9861718 Regulation of pyruvate metabolism
Reactome:R-RNO-9861718 Regulation of pyruvate metabolism
Reactome:R-BTA-9858328 OADH complex synthesizes glutaryl-CoA from 2-OA
Reactome:R-CEL-9858328 OADH complex synthesizes glutaryl-CoA from 2-OA
Reactome:R-HSA-9865118 Diseases of branched-chain amino acid catabolism
Reactome:R-HSA-9858328 OADH complex synthesizes glutaryl-CoA from 2-OA
Reactome:R-BTA-9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
Reactome:R-CEL-9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
Reactome:R-DDI-9858328 OADH complex synthesizes glutaryl-CoA from 2-OA
Reactome:R-HSA-9865113 Loss-of-function mutations in DBT cause MSUD2
Reactome:R-HSA-9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
Reactome:R-MMU-9858328 OADH complex synthesizes glutaryl-CoA from 2-OA
Reactome:R-RNO-9858328 OADH complex synthesizes glutaryl-CoA from 2-OA
Reactome:R-HSA-9865114 Maple Syrup Urine Disease
Reactome:R-HSA-9912529 H139Hfs13* PPM1K causes a mild variant of MSUD
Reactome:R-DDI-9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
Reactome:R-HSA-9912481 Branched-chain ketoacid dehydrogenase kinase deficiency
Reactome:R-MMU-9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
Reactome:R-RNO-9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-BTA-71403 Citric acid cycle (TCA cycle)
Reactome:R-BTA-71291 Amino acid and derivative metabolism
Reactome:R-BTA-6783984 Glycine degradation
Reactome:R-CEL-5362517 Signaling by Retinoic Acid
Reactome:R-CEL-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-CEL-70895 Branched-chain amino acid catabolism
Reactome:R-CEL-71064 Lysine catabolism
Reactome:R-DDI-70268 Pyruvate metabolism
Reactome:R-DDI-6783984 Glycine degradation
Reactome:R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-HSA-70895 Branched-chain amino acid catabolism
Reactome:R-HSA-71064 Lysine catabolism
Reactome:R-HSA-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-HSA-5362517 Signaling by Retinoic Acid
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-MMU-70895 Branched-chain amino acid catabolism
Reactome:R-MMU-71064 Lysine catabolism
Reactome:R-MMU-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-RNO-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-RNO-70895 Branched-chain amino acid catabolism
Reactome:R-RNO-71064 Lysine catabolism
Reactome:R-RNO-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-SCE-71291 Amino acid and derivative metabolism
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-SPO-71403 Citric acid cycle (TCA cycle)
Reactome:R-SPO-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-BTA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-BTA-70895 Branched-chain amino acid catabolism
Reactome:R-BTA-71064 Lysine catabolism
Reactome:R-BTA-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-CEL-9006931 Signaling by Nuclear Receptors
Reactome:R-CEL-70268 Pyruvate metabolism
Reactome:R-CEL-6783984 Glycine degradation
Reactome:R-DDI-71291 Amino acid and derivative metabolism
Reactome:R-DDI-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-HSA-70268 Pyruvate metabolism
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-1222499 Latent infection - Other responses of Mtb to phagocytosis
Reactome:R-MMU-70268 Pyruvate metabolism
Reactome:R-RNO-70268 Pyruvate metabolism
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-70268 Pyruvate metabolism
Reactome:R-SPO-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-SPO-71291 Amino acid and derivative metabolism
Reactome:R-BTA-9006931 Signaling by Nuclear Receptors
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-CEL-71403 Citric acid cycle (TCA cycle)
Reactome:R-CEL-71291 Amino acid and derivative metabolism
Reactome:R-HSA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-HSA-71403 Citric acid cycle (TCA cycle)
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-6783984 Glycine degradation
Reactome:R-HSA-5668914 Diseases of metabolism
Reactome:R-MMU-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-71403 Citric acid cycle (TCA cycle)
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-MMU-6783984 Glycine degradation
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-RNO-71403 Citric acid cycle (TCA cycle)
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-RNO-6783984 Glycine degradation
Reactome:R-RNO-5362517 Signaling by Retinoic Acid
Reactome:R-SCE-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-SCE-71403 Citric acid cycle (TCA cycle)
Reactome:R-SCE-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-SPO-6783984 Glycine degradation
Reactome:R-SPO-162582 Signaling Pathways
Reactome:R-SPO-9006931 Signaling by Nuclear Receptors
Reactome:R-BTA-70268 Pyruvate metabolism
Reactome:R-BTA-5362517 Signaling by Retinoic Acid
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-DDI-71403 Citric acid cycle (TCA cycle)
Reactome:R-DDI-70895 Branched-chain amino acid catabolism
Reactome:R-DDI-71064 Lysine catabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-1222541 Cell redox homeostasis
Reactome:R-MMU-5362517 Signaling by Retinoic Acid
Reactome:R-SCE-6783984 Glycine degradation
Reactome:R-SPO-70268 Pyruvate metabolism
Reactome:R-SPO-5362517 Signaling by Retinoic Acid
WikiPathways:WP4686 Leucine, isoleucine and valine metabolism
WikiPathways:WP5220 Metabolic reprogramming in pancreatic cancer
PathBank:SMP0120662 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0120666 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120694 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0120714 Homocarnosinosis
PathBank:SMP0120726 Leigh Syndrome
PathBank:SMP0120734 Malonic Aciduria
PathBank:SMP0120746 Saccharopinuria/Hyperlysinemia II
PathBank:SMP0120754 Non-Ketotic Hyperglycinemia
PathBank:SMP0120770 Hyperglycinemia, Non-Ketotic
PathBank:SMP0120786 Malonyl-CoA Decarboxylase Deficiency
PathBank:SMP0120806 3-Hydroxyisobutyric Aciduria
PathBank:SMP0120830 Fumarase Deficiency
PathBank:SMP0120834 Pyruvate Dehydrogenase Deficiency (E2)
PathBank:SMP0120842 Pyruvate Kinase Deficiency
PathBank:SMP0120850 Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120854 Pyridoxine Dependency with Seizures
PathBank:SMP0120870 2-Aminoadipic 2-Oxoadipic Aciduria
PathBank:SMP0000032 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0000016 Propanoate Metabolism
PathBank:SMP0000009 Ammonia Recycling
PathBank:SMP0000173 beta-Ketothiolase Deficiency
PathBank:SMP0000199 Maple Syrup Urine Disease
PathBank:SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000239 Saccharopinuria/Hyperlysinemia II
PathBank:SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0000242 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0000223 Non-Ketotic Hyperglycinemia
PathBank:SMP0000141 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0000484 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0000524 Isovaleric Acidemia
PathBank:SMP0000528 Hyperlysinemia II or Saccharopinuria
PathBank:SMP0000548 Mitochondrial Complex II Deficiency
PathBank:SMP0002295 The Oncogenic Action of Fumarate
PathBank:SMP0002358 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0002433 Leucine Degradation
PathBank:SMP0087177 Ammonia Recycling
PathBank:SMP0087234 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0087262 Threonine and 2-Oxobutanoate Degradation
PathBank:SMP0087270 Warburg Effect
PathBank:SMP0087274 Citric Acid Cycle
PathBank:SMP0087278 Glutamate Metabolism
PathBank:SMP0087282 Ammonia Recycling
PathBank:SMP0087338 Glycine and Serine Metabolism
PathBank:SMP0120661 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120665 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120705 Glutathione Synthetase Deficiency
PathBank:SMP0120741 Sarcosinemia
PathBank:SMP0120745 Methylmalonic Aciduria
PathBank:SMP0120753 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0120757 Propionic Acidemia
PathBank:SMP0120785 gamma-Glutamyltranspeptidase Deficiency
PathBank:SMP0120805 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0120829 Congenital Lactic Acidosis
PathBank:SMP0120833 Pyruvate Dehydrogenase Deficiency (E3)
PathBank:SMP0120841 Primary Hyperoxaluria II, PH2
PathBank:SMP0108771 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0000004 Glycine and Serine Metabolism
PathBank:SMP0000138 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0000140 3-Methylglutaconic Aciduria Type III
PathBank:SMP0000238 Isovaleric Aciduria
PathBank:SMP0000186 Glutaric Aciduria Type I
PathBank:SMP0000196 Leigh Syndrome
PathBank:SMP0000201 Methylmalonic Aciduria Due to Cobalamin-Related Disorders
PathBank:SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0000527 Hyperlysinemia I, Familial
PathBank:SMP0000547 Fumarase Deficiency
PathBank:SMP0000551 Pyruvate Dehydrogenase Deficiency (E2)
PathBank:SMP0000559 Pyruvate Kinase Deficiency
PathBank:SMP0000571 Pyridoxine Dependency with Seizures
PathBank:SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0002292 The Oncogenic Action of Succinate
PathBank:SMP0087245 Glycine and Serine Metabolism
PathBank:SMP0087277 Glutathione Metabolism
PathBank:SMP0087325 Pyruvate Metabolism
PathBank:SMP0087341 Propanoate Metabolism
PathBank:SMP0120660 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency
PathBank:SMP0120664 3-Methylglutaconic Aciduria Type III
PathBank:SMP0120700 gamma-Glutamyltransferase Deficiency
PathBank:SMP0120704 Glutaric Aciduria Type I
PathBank:SMP0120716 Hyperinsulinism-Hyperammonemia Syndrome
PathBank:SMP0120736 Maple Syrup Urine Disease
PathBank:SMP0120748 Methylmalonic Aciduria Due to Cobalamin-Related Disorders
PathBank:SMP0120784 5-Oxoprolinase Deficiency
PathBank:SMP0120808 Isovaleric Acidemia
PathBank:SMP0120812 Hyperlysinemia II or Saccharopinuria
PathBank:SMP0120832 2-Ketoglutarate Dehydrogenase Complex Deficiency
PathBank:SMP0120872 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0108773 Glutaminolysis and Cancer
PathBank:SMP0000057 Citric Acid Cycle
PathBank:SMP0000137 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0000200 Methylmalonic Aciduria
PathBank:SMP0000212 Pyruvate Dehydrogenase Complex Deficiency
PathBank:SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0000485 Hyperglycinemia, Non-Ketotic
PathBank:SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0000549 2-Ketoglutarate Dehydrogenase Complex Deficiency
PathBank:SMP0000654 Warburg Effect
PathBank:SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria
PathBank:SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0002460 Valine Degradation
PathBank:SMP0087163 Citric Acid Cycle
PathBank:SMP0087203 Lysine Degradation
PathBank:SMP0087231 Pyruvate Metabolism
PathBank:SMP0087248 Propanoate Metabolism
PathBank:SMP0087300 Lysine Degradation
PathBank:SMP0120659 2-Hydroxyglutric Aciduria (D and L Form)
PathBank:SMP0120663 3-Methylglutaconic Aciduria Type I
PathBank:SMP0120667 5-Oxoprolinuria
PathBank:SMP0120679 beta-Ketothiolase Deficiency
PathBank:SMP0120695 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0120723 Isovaleric Aciduria
PathBank:SMP0120743 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120751 Pyruvate Dehydrogenase Complex Deficiency
PathBank:SMP0120807 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0120811 Hyperlysinemia I, Familial
PathBank:SMP0120831 Mitochondrial Complex II Deficiency
PathBank:SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation
PathBank:SMP0000037 Lysine Degradation
PathBank:SMP0000060 Pyruvate Metabolism
PathBank:SMP0000452 Threonine and 2-Oxobutanoate Degradation
PathBank:SMP0000236 Propionic Acidemia
PathBank:SMP0000139 3-Methylglutaconic Aciduria Type I
PathBank:SMP0000244 Sarcosinemia
PathBank:SMP0000198 Malonic Aciduria
PathBank:SMP0000502 Malonyl-CoA Decarboxylase Deficiency
PathBank:SMP0000522 3-Hydroxyisobutyric Aciduria
PathBank:SMP0000546 Congenital Lactic Acidosis
PathBank:SMP0000550 Pyruvate Dehydrogenase Deficiency (E3)
PathBank:SMP0000558 Primary Hyperoxaluria II, PH2
PathBank:SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0002298 Glutaminolysis and Cancer
PathBank:SMP0002431 Isoleucine Degradation
PathBank:SMP0087327 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0087355 Threonine and 2-Oxobutanoate Degradation
PathBank:SMP0087363 Warburg Effect