EC: 2.7.7.84

2'-5' oligoadenylate synthase (ATP:ATP adenylyltransferase (2'-5' linkages-forming))

enzyme lambda metabolic reaction experiment
uniprot:P29728 [2'-5' oligoadenylate synthase(Enzyme) wildtype His6-tagged]

dATP + P1,P3_Bis(5'_adenosyl)_triphosphate -> ApppA2'p5'A + Diphosphate
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Tris-Cl, 20 mM magnesium acetate, 2.5 mM dithiothreitol
PH: 7
Temperature: 30
uniprot:P29728 [2'-5' oligoadenylate synthase(Enzyme) mutant heterodimer wt His6-tagged/DADA (D408A,D410A) FLAG-tagged]

dATP + P1,P3_Bis(5'_adenosyl)_triphosphate -> Diphosphate + ApppA2'p5'A
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Tris-Cl, 20 mM magnesium acetate, 2.5 mM dithiothreitol
PH: 7
Temperature: 30
uniprot:P29728 [2'-5' oligoadenylate synthase(Enzyme) mutant heterodimer wt His6-tagged/DADA (D408A,D410A) FLAG-tagged]

3 ATP -> 2 Diphosphate + pppA2'p5'A2'p5'A
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Tris-Cl, 20 mM magnesium acetate, 2.5 mM dithiothreitol
PH: 7
Temperature: 30
uniprot:P29728 [2'-5' oligoadenylate synthase(Enzyme) wildtype His6-tagged]

3 ATP -> 2 Diphosphate + pppA2'p5'A2'p5'A
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Tris-Cl, 20 mM magnesium acetate, 2.5 mM dithiothreitol
PH: 7
Temperature: 30
uniprot:P29728 [dsRNA]

3 ATP -> 2 Diphosphate + pppA2'p5'A2'p5'A
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Tris-Cl, 2.5 mM dithiothreitol
PH: 7.4
Temperature: 30
uniprot:Q9Z2F2 [dsRNA]

3 ATP -> 2 Diphosphate + pppA2'p5'A2'p5'A
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 75 mM Mg(OAc)2, 1 mM dithiothreitol, 0.2 mM EDTA, 0.5 mg/ml bovine serum albumin, 10% (v/v) glycerol, 30 mM creatine phosphate, 0.5 mg/ml creatine kinase
PH: 7.5
Temperature: 37
uniprot:Q9Z2F2 [dsRNA]

3 ATP -> 2 Diphosphate + pppA2'p5'A2'p5'A
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 75 mM Mg(OAc)2, 1 mM dithiothreitol, 0.2 mM EDTA, 0.5 mg/ml bovine serum albumin, 10% (v/v) glycerol, 30 mM creatine phosphate, 0.5 mg/ml creatine kinase
PH: 7.5
Temperature: 37
uniprot:P00973 [dsRNA]

3 ATP -> pppA2'p5'A2'p5'A + 2 Diphosphate
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 75 mM Mg(OAc)2, 1 mM dithiothreitol, 0.2 mM EDTA, 0.5 mg/ml bovine serum albumin, 10% (v/v) glycerol, 30 mM creatine phosphate, 0.5 mg/ml creatine kinase
PH: 7.5
Temperature: 37
uniprot:P00973 [dsRNA]

3 ATP -> pppA2'p5'A2'p5'A + 2 Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 75 mM Mg(OAc)2, 1 mM dithiothreitol, 0.2 mM EDTA, 0.5 mg/ml bovine serum albumin, 10% (v/v) glycerol, 30 mM creatine phosphate, 0.5 mg/ml creatine kinase
PH: 7.5
Temperature: 37
uniprot:P00973 [dsRNA]

3 ATP -> pppA2'p5'A2'p5'A + 2 Diphosphate
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 75 mM Mg(OAc)2, 1 mM dithiothreitol, 0.2 mM EDTA, 0.5 mg/ml bovine serum albumin, 10% (v/v) glycerol, 30 mM creatine phosphate, 0.5 mg/ml creatine kinase
PH: 7.5
Temperature: 37

Pathways

pathway id name
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway
Reactome:R-HSA-9833110 RSV-host interactions
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-HSA-913531 Interferon Signaling
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-8983711 OAS antiviral response
WikiPathways:WP4705 Pathways of nucleic acid metabolism and innate immune sensing