EC: 2.3.2.26

HECT-type E3 ubiquitin transferase ([E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming))

enzyme lambda metabolic reaction experiment

Pathways

pathway id name
Reactome:R-HSA-9679506 SARS-CoV Infections
Reactome:R-HSA-9692914 SARS-CoV-1-host interactions
Reactome:R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses
Reactome:R-HSA-9678108 SARS-CoV-1 Infection
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-CEL-1253288 Downregulation of ERBB4 signaling
Reactome:R-CEL-4641258 Degradation of DVL
Reactome:R-DRE-2173788 Downregulation of TGF-beta receptor signaling
Reactome:R-DRE-201681 TCF dependent signaling in response to WNT
Reactome:R-DME-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DME-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-DME-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-DME-195721 Signaling by WNT
Reactome:R-DME-3858494 Beta-catenin independent WNT signaling
Reactome:R-DME-5632684 Hedgehog 'on' state
Reactome:R-DME-8941858 Regulation of RUNX3 expression and activity
Reactome:R-HSA-5675482 Regulation of necroptotic cell death
Reactome:R-HSA-5693532 DNA Double-Strand Break Repair
Reactome:R-HSA-5693538 Homology Directed Repair
Reactome:R-HSA-9006936 Signaling by TGFB family members
Reactome:R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Reactome:R-HSA-157118 Signaling by NOTCH
Reactome:R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
Reactome:R-HSA-201681 TCF dependent signaling in response to WNT
Reactome:R-HSA-5610780 Degradation of GLI1 by the proteasome
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-2990846 SUMOylation
Reactome:R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-162587 HIV Life Cycle
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-936440 Negative regulators of RIG-I/MDA5 signaling
Reactome:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-913531 Interferon Signaling
Reactome:R-MMU-5693607 Processing of DNA double-strand break ends
Reactome:R-MMU-5357801 Programmed Cell Death
Reactome:R-MMU-5675482 Regulation of necroptotic cell death
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-1236394 Signaling by ERBB4
Reactome:R-MMU-1253288 Downregulation of ERBB4 signaling
Reactome:R-MMU-2173788 Downregulation of TGF-beta receptor signaling
Reactome:R-MMU-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
Reactome:R-MMU-4641257 Degradation of AXIN
Reactome:R-MMU-5632684 Hedgehog 'on' state
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-DRE-162582 Signaling Pathways
Reactome:R-DRE-2173789 TGF-beta receptor signaling activates SMADs
Reactome:R-DRE-195721 Signaling by WNT
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-DME-1236394 Signaling by ERBB4
Reactome:R-DME-9006936 Signaling by TGFB family members
Reactome:R-DME-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Reactome:R-DME-201451 Signaling by BMP
Reactome:R-DME-157118 Signaling by NOTCH
Reactome:R-DME-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
Reactome:R-DME-4641257 Degradation of AXIN
Reactome:R-DME-8878171 Transcriptional regulation by RUNX1
Reactome:R-DME-8878159 Transcriptional regulation by RUNX3
Reactome:R-HSA-5213460 RIPK1-mediated regulated necrosis
Reactome:R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-2173788 Downregulation of TGF-beta receptor signaling
Reactome:R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-HSA-9012852 Signaling by NOTCH3
Reactome:R-HSA-195721 Signaling by WNT
Reactome:R-HSA-4641257 Degradation of AXIN
Reactome:R-HSA-162906 HIV Infection
Reactome:R-HSA-162599 Late Phase of HIV Life Cycle
Reactome:R-HSA-162588 Budding and maturation of HIV virion
Reactome:R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome:R-HSA-8939902 Regulation of RUNX2 expression and activity
Reactome:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-HSA-913531 Interferon Signaling
Reactome:R-MMU-1280215 Cytokine Signaling in Immune system
Reactome:R-MMU-5693606 DNA Double Strand Break Response
Reactome:R-MMU-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-MMU-5213460 RIPK1-mediated regulated necrosis
Reactome:R-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-MMU-2173789 TGF-beta receptor signaling activates SMADs
Reactome:R-MMU-9012852 Signaling by NOTCH3
Reactome:R-MMU-4641258 Degradation of DVL
Reactome:R-MMU-5610780 Degradation of GLI1 by the proteasome
Reactome:R-RNO-1236394 Signaling by ERBB4
Reactome:R-RNO-1253288 Downregulation of ERBB4 signaling
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-913531 Interferon Signaling
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-1236394 Signaling by ERBB4
Reactome:R-CEL-195721 Signaling by WNT
Reactome:R-CEL-201681 TCF dependent signaling in response to WNT
Reactome:R-DRE-9006936 Signaling by TGFB family members
Reactome:R-DME-2173789 TGF-beta receptor signaling activates SMADs
Reactome:R-DME-201681 TCF dependent signaling in response to WNT
Reactome:R-DME-4086400 PCP/CE pathway
Reactome:R-DME-74160 Gene expression (Transcription)
Reactome:R-DME-73857 RNA Polymerase II Transcription
Reactome:R-DME-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome:R-HSA-5357801 Programmed Cell Death
Reactome:R-HSA-5693606 DNA Double Strand Break Response
Reactome:R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-HSA-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-HSA-1980143 Signaling by NOTCH1
Reactome:R-HSA-5610787 Hedgehog 'off' state
Reactome:R-HSA-5632684 Hedgehog 'on' state
Reactome:R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-8878171 Transcriptional regulation by RUNX1
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-1169408 ISG15 antiviral mechanism
Reactome:R-MMU-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-MMU-73894 DNA Repair
Reactome:R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-9006936 Signaling by TGFB family members
Reactome:R-MMU-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Reactome:R-MMU-157118 Signaling by NOTCH
Reactome:R-MMU-1980143 Signaling by NOTCH1
Reactome:R-MMU-195721 Signaling by WNT
Reactome:R-MMU-5610787 Hedgehog 'off' state
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-MMU-2990846 SUMOylation
Reactome:R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
Reactome:R-RNO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-RNO-1169408 ISG15 antiviral mechanism
Reactome:R-CEL-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DRE-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-DRE-4641257 Degradation of AXIN
Reactome:R-DME-1253288 Downregulation of ERBB4 signaling
Reactome:R-DME-2173788 Downregulation of TGF-beta receptor signaling
Reactome:R-DME-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome:R-DME-1980143 Signaling by NOTCH1
Reactome:R-DME-4608870 Asymmetric localization of PCP proteins
Reactome:R-DME-5358351 Signaling by Hedgehog
Reactome:R-DME-212436 Generic Transcription Pathway
Reactome:R-HSA-5218859 Regulated Necrosis
Reactome:R-HSA-73894 DNA Repair
Reactome:R-HSA-5693607 Processing of DNA double-strand break ends
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-1236394 Signaling by ERBB4
Reactome:R-HSA-1253288 Downregulation of ERBB4 signaling
Reactome:R-HSA-2173789 TGF-beta receptor signaling activates SMADs
Reactome:R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
Reactome:R-HSA-4641258 Degradation of DVL
Reactome:R-HSA-5358351 Signaling by Hedgehog
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-8878166 Transcriptional regulation by RUNX2
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-MMU-1169408 ISG15 antiviral mechanism
Reactome:R-MMU-5693532 DNA Double-Strand Break Repair
Reactome:R-MMU-5693538 Homology Directed Repair
Reactome:R-MMU-5218859 Regulated Necrosis
Reactome:R-MMU-8878171 Transcriptional regulation by RUNX1
Reactome:R-MMU-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-MMU-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
Reactome:R-MMU-201681 TCF dependent signaling in response to WNT
Reactome:R-MMU-5358351 Signaling by Hedgehog
Reactome:R-MMU-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-RNO-1280215 Cytokine Signaling in Immune system
WikiPathways:WP4016 DNA IR-damage and cellular response via ATR