EC: 3.4.21.6

coagulation factor Xa ()

enzyme lambda metabolic reaction experiment
uniprot:P00742 [coagulation factor Xa(Enzyme) wildtype]

N_alpha_Cbo_D_Arg_Gly_Arg_p_nitroanilide + H2O -> 4_Nitroaniline + N_alpha_Cbo_D_Arg_Gly_Arg
(( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 20 mM Hepes, 0.15 M NaCl, 0.01 % BSA, 2 % DMSO, 1 % DMF
PH: 7.5
Temperature: 25

Pathways

pathway id name
Reactome:R-HSA-9673202 Defective F9 variant does not activate FX
Reactome:R-HSA-9672396 Defective cofactor function of FVIIIa variant
Reactome:R-HSA-9671793 Diseases of hemostasis
Reactome:R-HSA-9662001 Defective factor VIII causes hemophilia A
Reactome:R-HSA-9668250 Defective factor IX causes hemophilia B
Reactome:R-HSA-9651496 Defects of Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-HSA-9672383 Defective factor IX causes thrombophilia
Reactome:R-GGA-597592 Post-translational protein modification
Reactome:R-GGA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
Reactome:R-GGA-140877 Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-HSA-140875 Common Pathway of Fibrin Clot Formation
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
Reactome:R-MMU-159740 Gamma-carboxylation of protein precursors
Reactome:R-RNO-597592 Post-translational protein modification
Reactome:R-RNO-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-140834 Extrinsic Pathway of Fibrin Clot Formation
Reactome:R-GGA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome:R-GGA-140875 Common Pathway of Fibrin Clot Formation
Reactome:R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
Reactome:R-HSA-159740 Gamma-carboxylation of protein precursors
Reactome:R-MMU-140834 Extrinsic Pathway of Fibrin Clot Formation
Reactome:R-MMU-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-RNO-159740 Gamma-carboxylation of protein precursors
Reactome:R-RNO-140877 Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-GGA-392499 Metabolism of proteins
Reactome:R-GGA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Reactome:R-GGA-109582 Hemostasis
Reactome:R-GGA-140834 Extrinsic Pathway of Fibrin Clot Formation
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Reactome:R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
Reactome:R-MMU-140875 Common Pathway of Fibrin Clot Formation
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome:R-RNO-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Reactome:R-RNO-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
Reactome:R-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation
Reactome:R-GGA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome:R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation
Reactome:R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome:R-MMU-109582 Hemostasis
Reactome:R-MMU-140877 Formation of Fibrin Clot (Clotting Cascade)
Reactome:R-MMU-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Reactome:R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
Reactome:R-RNO-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Reactome:R-RNO-140875 Common Pathway of Fibrin Clot Formation
WikiPathways:WP4583 Biomarkers for urea cycle disorders
WikiPathways:WP5186 Vitamin K metabolism and activation of dependent proteins
PathBank:SMP0119394 Coagulation
PathBank:SMP0000274 Heparin Action Pathway
PathBank:SMP0000278 Lepirudin Action Pathway
PathBank:SMP0000282 Streptokinase Action Pathway
PathBank:SMP0000286 Aminocaproic Acid Action Pathway
PathBank:SMP0000269 Acenocoumarol Action Pathway
PathBank:SMP0119377 Coagulation
PathBank:SMP0000273 Fondaparinux Action Pathway
PathBank:SMP0000277 Bivalirudin Action Pathway
PathBank:SMP0000281 Anistreplase Action Pathway
PathBank:SMP0000285 Reteplase Action Pathway
PathBank:SMP0000268 Warfarin Action Pathway
PathBank:SMP0000656 Dicoumarol Action Pathway
PathBank:SMP0000275 Ardeparin Action Pathway
PathBank:SMP0000279 Ximelagatran Action Pathway
PathBank:SMP0000283 Tenecteplase Action Pathway
PathBank:SMP0000287 Tranexamic Acid Action Pathway
PathBank:SMP0000270 Dicumarol Action Pathway
PathBank:SMP0000586 Coagulation
PathBank:SMP0000272 Enoxaparin Action Pathway
PathBank:SMP0000276 Argatroban Action Pathway
PathBank:SMP0000280 Alteplase Action Pathway
PathBank:SMP0000284 Urokinase Action Pathway
PathBank:SMP0000288 Aprotinin Action Pathway
PathBank:SMP0000271 Phenprocoumon Action Pathway
PathBank:SMP0000655 Phenindione Action Pathway