EC: 3.4.21.42

complement subcomponent C1s ()

enzyme lambda metabolic reaction experiment
uniprot:P09871 [complement subcomponent C_overbar_1s_(Enzyme) wildtype C1s]

Complement_component_C4 + H2O -> Complement_component_C4b + Complement_component_C4a		 (( (( (kcat * E) ) * S) ) / (S + Km)) buffer: 150 mM NaCl, 5 mM EDTA, 20 mM sodium phosphate.
PH: 7.4
Temperature: 37
uniprot:P09871 [complement subcomponent C_overbar_1s_(Enzyme) wildtype C1s]

Complement_component_C2 + H2O -> Complement_component_C2a + Complement_component_C2b		 (( (( (kcat * E) ) * S) ) / (S + Km)) buffer: 150 mM NaCl, 5 mM EDTA, 20 mM sodium phosphate.
PH: 7.4
Temperature: 37
uniprot:P09871 [complement subcomponent C_overbar_1s_(Enzyme) wildtype C1s]

N_Benzoyl_L_arginine_ethyl_ester + H2O -> N_Benzoyl_L_arginine + Ethanol		 (( (( (kcat * E) ) * S) ) / (S + Km)) buffer: not available
PH: 7
Temperature: 30
uniprot:P09871 [complement subcomponent C_overbar_1s_(Enzyme) wildtype C1s]

H2O + p_Tosyl_L_arginine_methyl_ester -> p_Tosyl_L_arginine + Methanol		 (( (( (kcat * E) ) * S) ) / (S + Km)) buffer: 100 mM K2HPO4, 1.6 U/ml alcohol oxidase, 1 U/ml horseradish peroxidase type VI, 0.5 mg/ml ABTS
PH: 7.5
Temperature: 30
uniprot:P09871 [complement subcomponent C_overbar_1s_(Enzyme) wildtype C1s]

N_Carboxybenzyloxyglycine_L_arginine_thiobenzyl_ester + H2O -> Benzylthiol + N_Carboxybenzyloxyglycine_L_arginine		 (( (( (kcat * E) ) * S) ) / (S + Km)) buffer: 0.01 M HEPES, 0.01 M CaCl2, 9.2 % (v/v) Me2SO
PH: 7.5
Temperature: 30
uniprot:P09871 [complement subcomponent C_overbar_1s_(Enzyme) wildtype C1s]

H2O + N_Acetyl_Gly_Lys_methyl_ester -> Methanol + N_Acetyl_Gly_Lys		 (( (( (kcat * E) ) * S) ) / (S + Km)) buffer: 100 mM K2HPO4, 1.6 U/ml alcohol oxidase, 1 U/ml horseradish peroxidase type VI, 0.5 mg/ml ABTS
PH: 7.5
Temperature: 30

Pathways

pathway id name
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9920588 Dengue virus activates/modulates innate and adaptive immune responses
Reactome:R-HSA-9839923 Dengue Virus Infection
Reactome:R-HSA-9918481 Dengue Virus-Host Interactions
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-MMU-166658 Complement cascade
Reactome:R-MMU-977606 Regulation of Complement cascade
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-168249 Innate Immune System
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-166658 Complement cascade
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-977606 Regulation of Complement cascade
Reactome:R-RNO-166658 Complement cascade
Reactome:R-RNO-977606 Regulation of Complement cascade
PathBank:SMP0120903 Complement Pathway
PathBank:SMP0120927 Complement Pathway
PathBank:SMP0064047 Classical Complement Pathway
PathBank:SMP0120930 Lectin-Induced Complement Pathway
PathBank:SMP0063814 Complement Pathway
PathBank:SMP0120908 Classical Complement Pathway
PathBank:SMP0120932 Classical Complement Pathway