glycine biosynthesis II

Maaheimo H, Fiaux J, Çakar ZP, Bailey JE, Sauer U, Szyperski T. Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C labeling of common amino acids. European Journal of Biochemistry. 2001 Apr 15;268(8):2464–79. doi: 10.1046/j.1432-1327.2001.02126.x.; Perham RN. Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions. Annu Rev Biochem. 2000;69():961–1004. doi: 10.1146/annurev.biochem.69.1.961. PMID: 10966480.; Pasternack LB, Laude DA, Appling DR. 13C NMR detection of folate-mediated serine and glycine synthesis in vivo in Saccharomyces cerevisiae. Biochemistry. 1992 Sep 22;31(37):8713–9. doi: 10.1021/bi00152a005. PMID: 1390656.; Motokawa Y, Kikuchi G. Glycine metabolism by rat liver mitochondria. Isolation and some properties of the protein-bound intermediate of the reversible glycine cleavage reaction. Arch Biochem Biophys. 1974 Oct;164(2):634–40. doi: 10.1016/0003-9861(74)90075-7. PMID: 4460883.; Hiraga K, Kochi H, Motokawa Y, Kikuchi G. Enzyme complex nature of the reversible glycine cleavage system of cock liver mitochondria. J Biochem. 1972 Nov;72(5):1285–9. doi: 10.1093/oxfordjournals.jbchem.a130020. PMID: 4648867.; MASSEY V, GIBSON QH, VEEGER C. Intermediates in the catalytic action of lipoyl dehydrogenase (diaphorase). Biochem J. 1960 Nov;77():341–51. PMID: 13767908; PMCID: PMC1204990.; SAVAGE N. Preparation and properties of highly purified diaphorase. Biochem J. 1957 Sep;67(1):146–55. PMID: 13471525; PMCID: PMC1200122.; Straub FB. Isolation and properties of a flavoprotein from heart muscle tissue. Biochem J. 1939 May;33(5):787–92. PMID: 16746974; PMCID: PMC1264446.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

methylammonium

Formula: CH6N (32.0500216)

CAS ID: 17000-00-9



Enzyme

EC Number name full name note
1.4.4.2 glycine dehydrogenase (aminomethyl-transferring) glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.1.2.10 aminomethyltransferase [protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)


Proteins

Protein ID name full name