Glyoxylate metabolism and glycine degradation
Danpure CJ. Primary hyperoxaluria: from gene defects to designer drugs? Nephrol Dial Transplant. 2005 Aug;20(8):1525–9. doi: 10.1093/ndt/gfh923. PMID: 15956068.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.4.3.3 | D-amino-acid oxidase | D-amino-acid:oxygen oxidoreductase (deaminating) | |
| 1.4.4.2 | glycine dehydrogenase (aminomethyl-transferring) | glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating) | |
| 1.5.5.2 | proline dehydrogenase | L-proline:quinone oxidoreductase | |
| 1.8.1.4 | dihydrolipoyl dehydrogenase | protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | |
| 2.1.2.10 | aminomethyltransferase | [protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) | |
| 2.3.1.61 | dihydrolipoyllysine-residue succinyltransferase | succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase | |
| 2.6.1.1 | aspartate transaminase | L-aspartate:2-oxoglutarate aminotransferase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| O00087 | dld1 | Dihydrolipoyl dehydrogenase, mitochondrial |
| O14110 | gcv1 | Probable aminomethyltransferase, mitochondrial |
| O74524 | PROD_SCHPO | Probable proline dehydrogenase, mitochondrial |
| O94320 | AATM_SCHPO | Aspartate aminotransferase, mitochondrial |
| O94681 | kgd2 | Probable dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| Q09785 | gcv2 | Putative glycine dehydrogenase (decarboxylating), mitochondrial |
| Q9Y7N4 | dao1 | D-amino-acid oxidase |