Branched-chain amino acid catabolism

Neinast M, Murashige D, Arany Z. Branched Chain Amino Acids. Annu. Rev. Physiol. 2019 Feb 10;81(1):139–64. doi: 10.1146/annurev-physiol-020518-114455.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

(E)-2-methylcrotonoyl-CoA

Formula: C26H38N7O17P3S (845.1257688000001)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

(S)-3-hydroxyisobutyrate

Formula: C4H7O3 (103.0395172)

CAS ID:

(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)

Formula: C27H39N7O20P3S (906.1183384)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

thiamine(1+) diphosphate(3-)

Formula: C12H16N4O7P2S (422.0214926)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.159 7alpha-hydroxysteroid dehydrogenase 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase
1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.31 3-hydroxyisobutyrate dehydrogenase 3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol:NAD(P)+ 17-oxidoreductase
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating) 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
1.3.8.1 short-chain acyl-CoA dehydrogenase short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
1.3.8.4 isovaleryl-CoA dehydrogenase 3-methylbutanoyl-CoA:electron-transfer flavoprotein oxidoreductase
1.3.8.5 short-chain 2-methylacyl-CoA dehydrogenase short-chain 2-methylacyl-CoA:electron-transfer flavoprotein 2-oxidoreductase
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase 2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase
2.3.1.9 acetyl-CoA C-acetyltransferase acetyl-CoA:acetyl-CoA C-acetyltransferase
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase
3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase 3-hydroxy-2-methylpropanoyl-CoA hydrolase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.52 [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphate phosphohydrolase
4.2.1.17 enoyl-CoA hydratase (3S)-3-hydroxyacyl-CoA hydro-lyase
4.2.1.18 methylglutaconyl-CoA hydratase (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
4.2.1.56 itaconyl-CoA hydratase citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
5.3.3.8 DELTA3-DELTA2-enoyl-CoA isomerase (3Z/3E)-alk-3-enoyl-CoA (2E)-isomerase
6.4.1.4 methylcrotonoyl-CoA carboxylase 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)


Proteins

Protein ID name full name