glycine cleavage

Douce R, Bourguignon J, Neuburger M, Rébeillé F. The glycine decarboxylase system: a fascinating complex. Trends Plant Sci. 2001 Apr;6(4):167–76. doi: 10.1016/s1360-1385(01)01892-1. PMID: 11286922.; Perham RN. Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions. Annu Rev Biochem. 2000;69():961–1004. doi: 10.1146/annurev.biochem.69.1.961. PMID: 10966480.; Fujiwara K, Okamura-Ikeda K, Motokawa Y. Mechanism of the glycine cleavage reaction. Further characterization of the intermediate attached to H-protein and of the reaction catalyzed by T-protein. Journal of Biological Chemistry. 1984 Sep;259(17):10664–8. doi: 10.1016/s0021-9258(18)90562-4.; Hiraga K, Kochi H, Hayasaka K, Kikuchi G, Nyhan WL. Defective glycine cleavage system in nonketotic hyperglycinemia. Occurrence of a less active glycine decarboxylase and an abnormal aminomethyl carrier protein. J Clin Invest. 1981 Aug;68(2):525–34. PMID: 6790577; PMCID: PMC370827.; MASSEY V, GIBSON QH, VEEGER C. Intermediates in the catalytic action of lipoyl dehydrogenase (diaphorase). Biochem J. 1960 Nov;77():341–51. PMID: 13767908; PMCID: PMC1204990.; SAVAGE N. Preparation and properties of highly purified diaphorase. Biochem J. 1957 Sep;67(1):146–55. PMID: 13471525; PMCID: PMC1200122.; Straub FB. Isolation and properties of a flavoprotein from heart muscle tissue. Biochem J. 1939 May;33(5):787–92. PMID: 16746974; PMCID: PMC1264446.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

methylammonium

Formula: CH6N (32.0500216)

CAS ID: 17000-00-9



Enzyme

EC Number name full name note
1.4.4.2 glycine dehydrogenase (aminomethyl-transferring) glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.1.2.10 aminomethyltransferase [protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)


Proteins

Protein ID name full name
P0A9P0 lpdA Dihydrolipoyl dehydrogenase
P27248 gcvT Aminomethyltransferase
P33195 gcvP Glycine dehydrogenase (decarboxylating)