Succinyl-CoA Biosynthesis
Skalidis I, Kyrilis FL, Tüting C, Hamdi F, Träger TK, Belapure J, Hause G, Fratini M, O'Reilly FJ, Heilmann I, Rappsilber J, Kastritis PL. Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon. Commun Biol. 2023 May 22;6(1):552. PMID: 37217784; PMCID: PMC10203282.; Hevler JF, Albanese P, Cabrera-Orefice A, Potter A, Jankevics A, Misic J, Scheltema RA, Brandt U, Arnold S, Heck AJR. MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex. Open Biol. 2023 Mar;13(3):220363. PMID: 36854377; PMCID: PMC9974300.; Nagy B, Polak M, Ozohanics O, Zambo Z, Szabo E, Hubert A, Jordan F, Novacek J, Adam-Vizi V, Ambrus A. Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure. Biochimica et Biophysica Acta (BBA) - General Subjects. 2021 Jun;1865(6):129889. doi: 10.1016/j.bbagen.2021.129889.; Zhou ZH, McCarthy DB, O'Connor CM, Reed LJ, Stoops JK. The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes. Proc. Natl. Acad. Sci. U.S.A. 2001 Dec 18;98(26):14802–7. doi: 10.1073/pnas.011597698.; McCartney RG, Rice JE, Sanderson SJ, Bunik V, Lindsay H, Lindsay JG. Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components. J Biol Chem. 1998 Sep 11;273(37):24158–64. doi: 10.1074/jbc.273.37.24158. PMID: 9727038.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.