Threonine and 2-Oxobutanoate Degradation

Metabolites

(R)-Methylmalonyl-CoA

Formula: C25H40N7O19P3S (867.131248)

CAS ID: 73173-92-9

2-Oxobutanoate

Formula: C4H6O3 (102.0316926)

CAS ID: 600-18-0

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

Ammonia

Formula: NH3 (17.0265478)

CAS ID: 7664-41-7

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

L-Threonine

Formula: C4H9NO3 (119.0582404)

CAS ID: 72-19-5

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4



Enzyme

EC Number name full name note
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase 2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase
4.3.1.17 L-serine ammonia-lyase L-serine ammonia-lyase (pyruvate-forming)
4.3.1.19 threonine ammonia-lyase L-threonine ammonia-lyase (2-oxobutanoate-forming)
5.4.99.2 methylmalonyl-CoA mutase (R)-methylmalonyl-CoA CoA-carbonylmutase
6.4.1.3 propionyl-CoA carboxylase propanoyl-CoA:carbon-dioxide ligase (ADP-forming)


Proteins

Protein ID name full name