glycine cleavage

Kume A, Kure S, Tada K, Hiraga K. The impaired expression of glycine decarboxylase in patients with hyperglycinemias. Biochemical and Biophysical Research Communications. 1988 Jul;154(1):292–7. doi: 10.1016/0006-291x(88)90683-3.; Fujiwara K, Okamura-Ikeda K, Motokawa Y. Mechanism of the glycine cleavage reaction. Further characterization of the intermediate attached to H-protein and of the reaction catalyzed by T-protein. Journal of Biological Chemistry. 1984 Sep;259(17):10664–8. doi: 10.1016/s0021-9258(18)90562-4.; Hiraga K, Kochi H, Hayasaka K, Kikuchi G, Nyhan WL. Defective glycine cleavage system in nonketotic hyperglycinemia. Occurrence of a less active glycine decarboxylase and an abnormal aminomethyl carrier protein. J Clin Invest. 1981 Aug;68(2):525–34. PMID: 6790577; PMCID: PMC370827.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.4.4.2 glycine dehydrogenase (aminomethyl-transferring) glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.1.2.10 aminomethyltransferase [protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)


Proteins

Protein ID name full name