superpathway of glyoxylate bypass and TCA

Baldwin JE, Krebs H. The evolution of metabolic cycles. Nature. 1981 Jun 04;291(5814):381–2. doi: 10.1038/291381a0. PMID: 7242661.; KORNBERG HL, KREBS HA. Synthesis of cell constituents from C2-units by a modified tricarboxylic acid cycle. Nature. 1957 May 18;179(4568):988–91. doi: 10.1038/179988a0. PMID: 13430766.

Metabolites

Allicin

Formula: C6H10OS2 (162.01730500000002)

CAS ID: 539-86-6

Cadmium

Formula: Cd (113.903361)

CAS ID: 7440-43-9

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Cl-

Formula: Cl (34.968853)

CAS ID: 16887-00-6

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Silver

Formula: Ag (106.905095)

CAS ID: 7440-22-4

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Phenylglyoxal

Formula: C8H6O2 (134.0367776)

CAS ID: 1074-12-0

malonate(2-)

Formula: C3H2O4 (101.99530920000001)

CAS ID: 156-80-9

oxaloacetate(2-)

Formula: C4H2O5 (129.9902242)

CAS ID: 149-63-3

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

oxalate(2-)

Formula: C2O4 (87.97966)

CAS ID: 338-70-5

glycolate

Formula: C2H3O3 (75.00821880000001)

CAS ID: 666-14-8

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

glyoxylate

Formula: C2HO3 (72.9925696)

CAS ID:

citrate(3-)

Formula: C6H5O7 (189.00352800000002)

CAS ID: 126-44-3

3-oxalomalate(3-)

Formula: C6H3O8 (202.98279380000002)

CAS ID: 89304-26-7

tungstate

Formula: O4W (247.930613)

CAS ID: 14311-52-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.37 malate dehydrogenase (S)-malate:NAD+ oxidoreductase
1.1.1.42 isocitrate dehydrogenase (NADP+) isocitrate:NADP+ oxidoreductase (decarboxylating)
1.1.5.4 malate dehydrogenase (quinone) (S)-malate:quinone oxidoreductase
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring) 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase
2.3.3.16 citrate synthase (unknown stereospecificity) acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
2.3.3.9 malate synthase acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
4.1.3.1 isocitrate lyase isocitrate glyoxylate-lyase (succinate-forming)
4.2.1.2 fumarate hydratase (S)-malate hydro-lyase (fumarate-forming)
4.2.1.3 aconitate hydratase citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
4.2.1.81 D(-)-tartrate dehydratase (S,S)-tartrate hydro-lyase (oxaloacetate-forming)
4.2.1.99 2-methylisocitrate dehydratase (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]
5.3.2.2 oxaloacetate tautomerase oxaloacetate keto---enol-isomerase
6.2.1.5 succinate-CoA ligase (ADP-forming) succinate:CoA ligase (ADP-forming)


Proteins

Protein ID name full name
P05042 fumC Fumarate hydratase class II
P08200 icd Isocitrate dehydrogenase [NADP]
P08997 aceB Malate synthase A
P0A836 sucC Succinate--CoA ligase [ADP-forming] subunit beta
P0A9G6 aceA Isocitrate lyase
P0A9P0 lpdA Dihydrolipoyl dehydrogenase
P0ABH7 gltA Citrate synthase
P0AC33 fumA Fumarate hydratase class I, aerobic
P0ACX5 fumD Fumarase D
P0AFG3 sucA 2-oxoglutarate dehydrogenase E1 component
P0AFG6 sucB Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
P0AGE9 sucD Succinate--CoA ligase [ADP-forming] subunit alpha
P11663 fumE Fumarase E
P14407 fumB Fumarate hydratase class I, anaerobic
P25516 acnA Aconitate hydratase A
P33940 mqo Malate:quinone oxidoreductase
P36683 acnB Aconitate hydratase B
P61889 mdh Malate dehydrogenase