Bacterial Infection Pathways

Metabolites

Ammonia

Formula: NH3 (17.0265478)

CAS ID: 7664-41-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Mycothiol

Formula: C17H30N2O12S (486.15193800000003)

CAS ID: 192126-76-4

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Nitric oxide

Formula: NO (29.997989)

CAS ID: 10102-43-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

UDP-glucose

Formula: C15H24N2O17P2 (566.0550194)

CAS ID: 133-89-1

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Nitrate

Formula: NO3 (61.987819)

CAS ID: 14797-55-8

S-Nitrosoglutathione

Formula: C10H16N4O7S (336.0739666)

CAS ID: 57564-91-7

benzylpenicillin(1-)

Formula: C16H17N2O4S (333.0908982)

CAS ID: 54836-26-9

carbonate

Formula: CO3 (59.984745000000004)

CAS ID: 3812-32-6

nitrite

Formula: NO2 (45.992904)

CAS ID: 14797-65-0

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

oxidonitrogen(1+)

Formula: NO (29.997989)

CAS ID: 14452-93-8



Enzyme

EC Number name full name note
1.11.1.-
1.1.98.2 glucose-6-phosphate dehydrogenase (coenzyme-F420) D-glucose-6-phosphate:F420 1-oxidoreductase
1.11.1.2 NADPH peroxidase NADPH:hydrogen-peroxide oxidoreductase
1.11.1.21 catalase-peroxidase donor:hydrogen-peroxide oxidoreductase
1.11.1.24 thioredoxin-dependent peroxiredoxin thioredoxin:hydroperoxide oxidoreductase
1.11.1.28 lipoyl-dependent peroxiredoxin lipoyl:hydroperoxide oxidoreductase
1.11.1.29 mycoredoxin-dependent peroxiredoxin mycoredoxin:hydroperoxide oxidoreductase
1.14.13.39 nitric-oxide synthase (NADPH) L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
1.15.1.1 superoxide dismutase superoxide:superoxide oxidoreductase
1.16.1.9 ferric-chelate reductase (NADPH) Fe(II)-siderophore:NADP+ oxidoreductase
1.16.3.1 ferroxidase Fe(II):oxygen oxidoreductase
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
1.8.1.9 thioredoxin-disulfide reductase thioredoxin:NADP+ oxidoreductase
2.3.1.12 dihydrolipoyllysine-residue acetyltransferase acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.4.1.12 cellulose synthase (UDP-forming) UDP-glucose:(1->4)-beta-D-glucan 4-beta-D-glucosyltransferase
2.4.2.36 NAD+-diphthamide ADP-ribosyltransferase NAD+:diphthamide-[translation elongation factor 2] N-(ADP-D-ribosyl)transferase
2.4.99.28 peptidoglycan glycosyltransferase [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase
2.7.10.1 receptor protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
2.7.2.3 phosphoglycerate kinase ATP:3-phospho-D-glycerate 1-phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
2.7.7.6 DNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
3.1.1.108 iron(III)-enterobactin esterase iron(III)-enterobactin hydrolase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.2 acid phosphatase phosphate-monoester phosphohydrolase (acid optimum)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.1.3.64 phosphatidylinositol-3-phosphatase 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase
3.2.2.5 NAD+ glycohydrolase NAD+ glycohydrolase
3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase
3.4.21.20 cathepsin G
3.4.21.75 Furin
3.4.21.89 Signal peptidase I
3.4.22.57 caspase-4
3.4.24.68 tentoxilysin
3.4.24.69 bontoxilysin
3.4.24.83 anthrax lethal factor endopeptidase
3.5.2.6 beta-lactamase beta-lactam hydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)
4.2.1.11 phosphopyruvate hydratase 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
4.6.1.1 adenylate cyclase ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
4.6.1.2 guanylate cyclase GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
4.98.1.1 protoporphyrin ferrochelatase protoheme ferro-lyase (protoporphyrin-forming)
5.6.2.2 DNA topoisomerase (ATP-hydrolysing) DNA topoisomerase (ATP-hydrolysing)
7.2.2.16 ABC-type ferric hydroxamate transporter ATP phosphohydrolase [ABC-type, iron(III) hydroxamate-importing]
7.2.2.17 ABC-type ferric enterobactin transporter ATP phosphohydrolase (ABC-type, iron(III) enterobactin-importing)
7.2.2.18 ABC-type ferric citrate transporter ATP phosphohydrolase (ABC-type, iron(III) dicitrate-importing)
7.2.2.20 ABC-type Zn2+ transporter ATP phosphohydrolase (ABC-type, Zn2+-importing)
7.4.2.6 ABC-type oligopeptide transporter ATP phosphohydrolase (ABC-type, oligopeptide-importing)
7.4.2.8 protein-secreting ATPase ATP phosphohydrolase (protein-secreting)
7.4.2.9 ABC-type dipeptide transporter ATP phosphohydrolase (ABC-type, dipeptide-transporting)


Proteins

Protein ID name full name
A0A0H2US87 ospC3 Arginine ADP-riboxanase OspC3
O05442 Rv3903c Hypothetical alanine and proline rich protein
O53361 sapM Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase)
O88093 hbp Hemoglobin-binding protease hbp autotransporter
P00803 lepB Signal peptidase I
P02919 mrcB Penicillin-binding protein 1B
P04958 tetX tetanus toxin tetX
P07821 fhuC Iron(3+)-hydroxamate import ATP-binding protein FhuC
P0A3M3 bla Beta-lactamase OXA-9
P0A9X1 znuC Zinc import ATP-binding protein ZnuC
P0AAG0 dppD Dipeptide transport ATP-binding protein DppD
P0AES4 gyrA DNA gyrase subunit A
P0AES6 gyrB DNA gyrase subunit B
P0DPI0 botA Botulinum neurotoxin type A
P10408 secA Protein translocase subunit SecA
P10844 botB Botulinum neurotoxin type B
P13039 fes Iron(III) enterobactin esterase
P15031 fecE Fe(3+) dicitrate transport ATP-binding protein FecE
P15917 lef Lethal factor
P23878 fepC Ferric enterobactin transport ATP-binding protein FepC
P30996 botF Botulinum neurotoxin type F
P37313 dppF Dipeptide transport ATP-binding protein DppF
P37653 bcsA Cellulose synthase catalytic subunit [UDP-forming]
P40136 cya Calmodulin-sensitive adenylate cyclase
P62593 bla Beta-lactamase TEM
P75831 macB Macrolide export ATP-binding/permease protein MacB
P9WFK7 eis N-acetyltransferase Eis
P9WG35 tpx Thiol peroxidase
P9WGE7 sodB Superoxide dismutase [Fe]
P9WGE9 sodC Superoxide dismutase [Cu-Zn]
P9WGP3 secA2 Protein translocase subunit SecA 2
P9WGP5 secA1 Protein translocase subunit SecA 1
P9WGY5 rpoZ DNA-directed RNA polymerase subunit omega
P9WGY7 rpoC DNA-directed RNA polymerase subunit beta'
P9WGY9 rpoB DNA-directed RNA polymerase subunit beta
P9WGZ1 rpoA DNA-directed RNA polymerase subunit alpha
P9WHH1 trxB Thioredoxin reductase
P9WHH9 lpdC Dihydrolipoyl dehydrogenase
P9WIA1 ptpA Low molecular weight protein-tyrosine phosphatase A
P9WIE3 ahpE Alkyl hydroperoxide reductase E
P9WIE5 katG Catalase-peroxidase
P9WIS7 dlaT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
P9WJH7 ndkA Nucleoside diphosphate kinase
P9WNE1 fgd1 F420-dependent glucose-6-phosphate dehydrogenase Fgd1
P9WNE5 bfrB Bacterioferritin BfrB
P9WPQ9 bfr Bacterioferritin BfrA
P9WQB5 ahpD Alkyl hydroperoxide reductase AhpD
P9WQB7 ahpC Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C)
P9WQJ5 oppD Oligopeptide transport ATP-binding protein OppD
P9WQJ7 irtB Mycobactin import ATP-binding/permease protein IrtB
P9WQJ9 irtA Mycobactin import ATP-binding/permease protein IrtA
Q00496 botE Botulinum neurotoxin type E
Q46871 yqjH NADPH-dependent ferric-chelate reductase
Q60393 botG Botulinum neurotoxin type G
Q8VSC3 ipaH9.8 E3 ubiquitin-protein ligase ipaH9.8
Q8XAS4 efeB Deferrochelatase
Q9EZE7 espC Serine protease EspC
Q9F663 KPC-2 Carbapenem-hydrolyzing beta-lactamase KPC-2