Latent infection - Other responses of Mtb to phagocytosis
Russell DG. Mycobacterium tuberculosis and the intimate discourse of a chronic infection. Immunological Reviews. 2011 Feb 23;240(1):252–68. doi: 10.1111/j.1600-065x.2010.00984.x.; Russell DG, Barry CE, Flynn JL. Tuberculosis: what we don't know can, and does, hurt us. Science. 2010 May 14;328(5980):852–6. PMID: 20466922; PMCID: PMC2872107.; de Chastellier C. The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages. Immunobiology. 2009;214(7):526–42. doi: 10.1016/j.imbio.2008.12.005. PMID: 19261352.; Flannagan RS, Cosío G, Grinstein S. Antimicrobial mechanisms of phagocytes and bacterial evasion strategies. Nat Rev Microbiol. 2009 May;7(5):355–66. doi: 10.1038/nrmicro2128. PMID: 19369951.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.4.21.- | |||
| 1.1.98.2 | glucose-6-phosphate dehydrogenase (coenzyme-F420) | D-glucose-6-phosphate:F420 1-oxidoreductase | |
| 1.11.1.21 | catalase-peroxidase | donor:hydrogen-peroxide oxidoreductase | |
| 1.11.1.24 | thioredoxin-dependent peroxiredoxin | thioredoxin:hydroperoxide oxidoreductase | |
| 1.11.1.28 | lipoyl-dependent peroxiredoxin | lipoyl:hydroperoxide oxidoreductase | |
| 1.11.1.29 | mycoredoxin-dependent peroxiredoxin | mycoredoxin:hydroperoxide oxidoreductase | |
| 1.15.1.1 | superoxide dismutase | superoxide:superoxide oxidoreductase | |
| 1.16.3.1 | ferroxidase | Fe(II):oxygen oxidoreductase | |
| 1.8.1.4 | dihydrolipoyl dehydrogenase | protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | |
| 1.8.1.9 | thioredoxin-disulfide reductase | thioredoxin:NADP+ oxidoreductase | |
| 2.3.1.12 | dihydrolipoyllysine-residue acetyltransferase | acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase | |
| 7.4.2.6 | ABC-type oligopeptide transporter | ATP phosphohydrolase (ABC-type, oligopeptide-importing) | |
| 7.4.2.8 | protein-secreting ATPase | ATP phosphohydrolase (protein-secreting) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P9WG35 | tpx | Thiol peroxidase |
| P9WGE7 | sodB | Superoxide dismutase [Fe] |
| P9WGE9 | sodC | Superoxide dismutase [Cu-Zn] |
| P9WGP3 | secA2 | Protein translocase subunit SecA 2 |
| P9WGP5 | secA1 | Protein translocase subunit SecA 1 |
| P9WHH1 | trxB | Thioredoxin reductase |
| P9WHH9 | lpdC | Dihydrolipoyl dehydrogenase |
| P9WIE3 | ahpE | Alkyl hydroperoxide reductase E |
| P9WIE5 | katG | Catalase-peroxidase |
| P9WIS7 | dlaT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
| P9WNE1 | fgd1 | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| P9WNE5 | bfrB | Bacterioferritin BfrB |
| P9WPQ9 | bfr | Bacterioferritin BfrA |
| P9WQB5 | ahpD | Alkyl hydroperoxide reductase AhpD |
| P9WQB7 | ahpC | Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) |
| P9WQJ5 | oppD | Oligopeptide transport ATP-binding protein OppD |
| P9WQJ7 | irtB | Mycobactin import ATP-binding/permease protein IrtB |
| P9WQJ9 | irtA | Mycobactin import ATP-binding/permease protein IrtA |