leucine degradation

Massey LK, Conrad RS, Sokatch JR. Regulation of Leucine Catabolism in Pseudomonas putida. J Bacteriol. 1974 Apr;118(1):112–20. doi: 10.1128/jb.118.1.112-120.1974.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

acetoacetate

Formula: C4H5O3 (101.02386800000001)

CAS ID: 141-81-1

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

4-methyl-2-oxopentanoate

Formula: C6H9O3 (129.05516640000002)

CAS ID:

biotinate

Formula: C10H15N2O3S (243.080334)

CAS ID:

(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)

Formula: C27H39N7O20P3S (906.1183384)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
1.3.8.1 short-chain acyl-CoA dehydrogenase short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
1.3.8.4 isovaleryl-CoA dehydrogenase 3-methylbutanoyl-CoA:electron-transfer flavoprotein oxidoreductase
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase 2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-(2-methylpropanoyl)transferase
2.6.1.42 branched-chain-amino-acid transaminase branched-chain-amino-acid:2-oxoglutarate aminotransferase
4.1.3.4 hydroxymethylglutaryl-CoA lyase (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
4.2.1.18 methylglutaconyl-CoA hydratase (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
4.2.1.56 itaconyl-CoA hydratase citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
6.4.1.4 methylcrotonoyl-CoA carboxylase 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)


Proteins

Protein ID name full name