Pyruvate metabolism
Prochownik EV, Wang H. The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells. Cells. 2021 Mar 30;10(4). PMID: 33808495; PMCID: PMC8066905.; Reed LJ, Hackert ML. Structure-function relationships in dihydrolipoamide acyltransferases. Journal of Biological Chemistry. 1990 Jun;265(16):8971–4. doi: 10.1016/s0021-9258(19)38795-2.; Cori CF. The glucose-lactic acid cycle and gluconeogenesis. Curr Top Cell Regul. 1981;18():377–87. PMID: 7273846.
Metabolites
beta-D-fructofuranose 1,6-bisphosphate(4-)
Formula: C6H10O12P2 (335.96475200000003)
CAS ID: 488-69-7
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.2.4.1 | pyruvate dehydrogenase (acetyl-transferring) | pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) | |
| 1.8.1.4 | dihydrolipoyl dehydrogenase | protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | |
| 2.3.1.12 | dihydrolipoyllysine-residue acetyltransferase | acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase | |
| 2.6.1.2 | alanine transaminase | L-alanine:2-oxoglutarate aminotransferase | |
| 2.7.1.40 | pyruvate kinase | ATP:pyruvate 2-O-phosphotransferase | |
| 3.1.2.6 | hydroxyacylglutathione hydrolase | S-(2-hydroxyacyl)glutathione hydrolase | |
| 4.4.1.5 | lactoylglutathione lyase | (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming) | |
| 5.3.2.2 | oxaloacetate tautomerase | oxaloacetate keto---enol-isomerase | |
| 6.4.1.1 | pyruvate carboxylase | pyruvate:carbon-dioxide ligase (ADP-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P00549 | CDC19 | Pyruvate kinase 1 |
| P09624 | LPD1 | Dihydrolipoyl dehydrogenase, mitochondrial |
| P11154 | PYC1 | Pyruvate carboxylase 1 |
| P12695 | LAT1 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| P16387 | PDA1 | Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial |
| P32473 | PDB1 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial |
| P50107 | GLO1 | Glyoxalase I |
| P52893 | ALT1 | Alanine aminotransferase, mitochondrial |
| P53889 | FMP41 | Oxaloacetate tautomerase FMP41, mitochondrial |
| Q12320 | GLO4 | Hydroxyacylglutathione hydrolase, mitochondrial |