Lysine catabolism

Goh DLM, Patel A, Thomas GH, Salomons GS, Schor DSM, Jakobs C, Geraghty MT. Characterization of the human gene encoding a-aminoadipate aminotransferase (AADAT). Molecular Genetics and Metabolism. 2002 Jul;76(3):172–80. doi: 10.1016/s1096-7192(02)00037-9.; Markovitz PJ, Chuang DT, Cox RP. Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities. Journal of Biological Chemistry. 1984 Oct;259(19):11643–6. doi: 10.1016/s0021-9258(20)71252-4.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Delta1-Piperideine-2-carboxylate

Formula: C6H9NO2 (127.0633254)

CAS ID: 2756-89-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Erythro-5-hydroxy-L-lysinium(1+)

Formula: C6H15N2O3 (163.108262)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

L-lysinium(1+)

Formula: C6H15N2O2 (147.113347)

CAS ID: 56-87-1



Enzyme

EC Number name full name note
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
1.2.1.8 betaine-aldehyde dehydrogenase betaine-aldehyde:NAD+ oxidoreductase
1.3.8.6 glutaryl-CoA dehydrogenase (ETF) glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase
1.5.1.25 thiomorpholine-carboxylate dehydrogenase thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming) N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming) N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
1.5.3.1 sarcosine oxidase (formaldehyde-forming) sarcosine:oxygen oxidoreductase (demethylating)
1.5.3.7 L-pipecolate oxidase L-pipecolate:oxygen 1,6-oxidoreductase
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase
2.6.1.39 2-aminoadipate transaminase L-2-aminoadipate:2-oxoglutarate aminotransferase
2.6.1.4 glycine transaminase glycine:2-oxoglutarate aminotransferase
2.6.1.63 kynurenine-glyoxylate transaminase L-kynurenine:glyoxylate aminotransferase (cyclizing)
2.6.1.7 kynurenine-oxoglutarate transaminase L-kynurenine:2-oxoglutarate aminotransferase
2.6.1.73 methionine-glyoxylate transaminase L-methionine:glyoxylate aminotransferase
2.7.1.81 hydroxylysine kinase GTP:5-hydroxy-L-lysine O-phosphotransferase
4.2.3.134 5-phosphooxy-L-lysine phospho-lyase (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)


Proteins

Protein ID name full name