The Oncogenic Action of Succinate

Metabolites

(S)-Malate

Formula: C4H6O5 (134.0215226)

CAS ID: 97-67-6

2-Hydroxyglutarate

Formula: C5H8O5 (148.0371718)

CAS ID: 2889-31-8

2-Oxoglutarate

Formula: C5H6O5 (146.0215226)

CAS ID: 328-50-7

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

cis-Aconitate

Formula: C6H6O6 (174.01643760000002)

CAS ID: 585-84-2

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

FAD

Formula: C27H33N9O15P2 (785.1571288000001)

CAS ID: 146-14-5

FADH2

Formula: C27H35N9O15P2 (787.1727780000001)

CAS ID: 1910-41-4

GDP

Formula: C10H15N5O11P2 (443.02433)

CAS ID: 146-91-8

GTP

Formula: C10H16N5O14P3 (522.9906626)

CAS ID: 86-01-1

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Hydroxyproline

Formula: C5H9NO3 (131.0582404)

CAS ID: 51-35-4

Isocitrate

Formula: C6H8O7 (192.0270018)

CAS ID: 320-77-4

L-Proline

Formula: C5H9NO2 (115.0633254)

CAS ID: 147-85-3

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Oxaloacetate

Formula: C4H4O5 (132.00587339999998)

CAS ID: 328-42-7

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3

Ubiquinone-10

Formula: C59H90O4 (862.683874)

CAS ID: 303-98-0

QH2

Formula: (C5H8)nC14H20O4 (680810.0415552)

CAS ID: 56275-39-9

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.1.5.-
1.1.1.41 isocitrate dehydrogenase (NAD+) isocitrate:NAD+ oxidoreductase (decarboxylating)
1.1.1.42 isocitrate dehydrogenase (NADP+) isocitrate:NADP+ oxidoreductase (decarboxylating)
1.14.11.29 hypoxia-inducible factor-proline dioxygenase hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring) pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
1.3.5.1 succinate dehydrogenase succinate:quinone oxidoreductase
1.8.1.4 dihydrolipoyl dehydrogenase protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2.3.1.12 dihydrolipoyllysine-residue acetyltransferase acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase
2.3.3.1 citrate (Si)-synthase acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
4.2.1.2 fumarate hydratase (S)-malate hydro-lyase (fumarate-forming)
4.2.1.3 aconitate hydratase citrate(isocitrate) hydro-lyase (cis-aconitate-forming)
6.2.1.4 succinate-CoA ligase (GDP-forming) succinate:CoA ligase (GDP-forming)
6.2.1.5 succinate-CoA ligase (ADP-forming) succinate:CoA ligase (ADP-forming)
6.2.1.9 malate-CoA ligase malate:CoA ligase (ADP-forming)
6.4.1.1 pyruvate carboxylase pyruvate:carbon-dioxide ligase (ADP-forming)


Proteins

Protein ID name full name