EC: 1.1.1.62

17beta-estradiol 17-dehydrogenase (17beta-estradiol:NAD(P)+ 17-oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:P50171 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NAD+ + Testosterone -> H+ + NADH + Androst_4_ene_3,17_dione		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Hepes, 20% glycerol, 1 mM MgCl2, 1 mM EDTA, 1 mM DTT
PH: 7.4
Temperature: 37
uniprot:P50171 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NAD+ + 5alpha_Androstane_17beta_ol_3_one -> NADH + 5alpha_Androstane_3,17_dione + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Hepes, 20% glycerol, 1 mM MgCl2, 1 mM EDTA, 1 mM DTT
PH: 7.4
Temperature: 37
uniprot:P50171 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Estradiol_17beta + NAD+ -> H+ + NADH + Estrone		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Hepes, 20% glycerol, 1 mM MgCl2, 1 mM EDTA, 1 mM DTT
PH: 7.4
Temperature: 37
uniprot:P50171 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Estrone + H+ + NADH -> Estradiol_17beta + NAD+		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate, 20% glycerol, 1 mM MgCl2, 1 mM EDTA, 1 mM DTT
PH: 7.4
Temperature: 37
uniprot:P42330 [Imipramine]

NADP+ + 5alpha_Androstane_3alpha,17beta_diol -> 5alpha_Androstane_3alpha_ol_17_one + H+ + NADPH		 (( (Vmax * A) ) / (Km_A + A)) buffer: 100 mM sodium phosphate
PH: 8.9
Temperature: 37
uniprot:P42330 [Paroxetine]

NADP+ + 5alpha_Androstane_3alpha,17beta_diol -> H+ + NADPH + 5alpha_Androstane_3alpha_ol_17_one		 (( (Vmax * A) ) / (Km_A + A)) buffer: 100 mM sodium phosphate
PH: 8.9
Temperature: 37
uniprot:P42330 [Fluoxetine]

NADP+ + 5alpha_Androstane_3alpha,17beta_diol -> 5alpha_Androstane_3alpha_ol_17_one + NADPH + H+		 (( (Vmax * A) ) / (Km_A + A)) buffer: 100 mM sodium phosphate
PH: 8.9
Temperature: 37
uniprot:P42330 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

5alpha_Androstane_3alpha,17beta_diol + NADP+ -> H+ + 5alpha_Androstane_3alpha_ol_17_one + NADPH		 (( (Vmax * A) ) / (Km_A + A)) buffer: 100 mM sodium phosphate
PH: 8.9
Temperature: 37
uniprot:P37059 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NAD+ + Estradiol_17beta -> NADH + H+ + Estrone		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate or 100 mM Tris-citrate
PH: 7.4
Temperature: 37
uniprot:P37059 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + NADH + Estrone -> Estradiol_17beta + NAD+		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate or 100 mM Tris-citrate
PH: 7.4
Temperature: 37
uniprot:P37059 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + NADH + Androst_4_ene_3,17_dione -> Testosterone + NAD+		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate or 100 mM Tris-citrate
PH: 7.4
Temperature: 37
uniprot:P37059 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Testosterone + NAD+ -> H+ + NADH + Androst_4_ene_3,17_dione		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate or 100 mM Tris-citrate
PH: 7.4
Temperature: 37
uniprot:P37059 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

20alpha_Hydroxy_4_pregnen_3_one + NAD+ -> Progesterone + NADH + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate or 100 mM Tris-citrate
PH: 7.4
Temperature: 37
uniprot:P37059 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

5alpha_Androstane_17beta_ol_3_one + NAD+ -> 5alpha_Androstane_3,17_dione + H+ + NADH		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate or 100 mM Tris-citrate
PH: 7.4
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + Estradiol_17beta -> H+ + NADPH + Estrone		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM KHCO3/K2CO3, 0.17% (w/v) Bovine serum albumin
PH: 9.9
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + Estradiol_17beta -> Estrone + H+ + NADPH		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM KHCO3/K2CO3, 0.17% (w/v) Bovine serum albumin
PH: 9.9
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + Estradiol_17beta -> H+ + NADPH + Estrone		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM KHCO3/K2CO3
PH: 9.9
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + Estradiol_17beta -> Estrone + NADPH + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM KHCO3/K2CO3
PH: 9.9
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADPH + Estrone + H+ -> NADP+ + Estradiol_17beta		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM KHCO3/K2CO3, 0.17% (w/v) Bovine serum albumin
PH: 9.9
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + NADPH + Estrone -> Estradiol_17beta + NADP+		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM KHCO3/K2CO3, 0.17% (w/v) Bovine serum albumin
PH: 9.9
Temperature: 37
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + Estrone + NADPH -> NADP+ + Estradiol_17beta		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADPH + H+ + 3beta_Hydroxyandrost_5_en_17_one -> Androst_5_ene_3beta,17beta_diol + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADPH + H+ + 17alpha_Hydroxyprogesterone -> NADP+ + 17alpha,20alpha_Dihydroxypregn_4_en_3_one		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

20alpha_Hydroxy_4_pregnen_3_one + NADP+ -> Progesterone + H+ + NADPH		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + 5alpha_Androstane_3,17_dione + NADPH -> NADP+ + 5alpha_Androstane_17beta_ol_3_one		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + NADPH + 3alpha_Hydroxy_5beta_androstan_17_one -> 5beta_Androstane_3alpha,17beta_diol + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADPH + H+ + 5beta_Androstane_3,17_dione -> NADP+ + 5beta_Androstane_17beta_ol_3_one		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

4_Androsten_3alpha_ol_17_one + H+ + NADPH -> NADP+ + Androst_4_ene_3alpha,17beta_diol		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

2 H+ + 2 NADH + (1R)_(_)_Camphorquinone -> 1,7,7_trimethylbicyclo[2.2.1]heptane_2,3_diol + 2 NAD+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + p_Nitrobenzaldehyde + NADPH -> p_Nitrobenzyl_alcohol + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + 6_tert_Butyl_2,3_epoxy_5_cyclohexene_1,4_dione + NADPH -> 6_tert_Butyl_2,3_epoxy_4_hydroxy_5_cyclohexene_1_one + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

9,10_Phenanthroquinone + NADPH + H+ -> Phenanthrene_9,10_diol + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

2 NADPH + (1S)_(+)_Camphorquinone + 2 H+ -> 1,7,7_trimethylbicyclo[2.2.1]heptane_2,3_diol + 2 NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + NADPH + Isatin -> NADP+ + 2,3_Dihydroxyindole		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

(1R)_(_)_Camphorquinone + 2 H+ + 2 NADPH -> 2 NADP+ + 1,7,7_trimethylbicyclo[2.2.1]heptane_2,3_diol		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Dimethylglyoxal + 2 NADPH + 2 H+ -> 2,3_Butanediol + 2 NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

2,3_Pentanedione + 2 H+ + 2 NADPH -> 2 NADP+ + 2,3_Pentanediol		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + 4_Chlorobenzaldehyde + NADPH -> NADP+ + p_Chlorobenzyl_alcohol		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Testosterone + NAD+ -> Androst_4_ene_3,17_dione + NADH + H+		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADPH + H+ + 5beta_Pregnane_3,20_dione -> 20alpha_Hydroxy_5beta_pregnan_3_one + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + NADPH + 21_Dehydrocortisol -> NADP+ + Cortisol		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADPH + H+ + 16_Ketoestrone -> 16_Hydroxyestrone + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

2 NADH + 2 H+ + (1R)_(_)_Camphorquinone -> 1,7,7_trimethylbicyclo[2.2.1]heptane_2,3_diol + 2 NAD+		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

2 NADPH + 2 H+ + (1R)_(_)_Camphorquinone -> 1,7,7_trimethylbicyclo[2.2.1]heptane_2,3_diol + 2 NADP+		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

9alpha,11beta_Prostaglandin_F2 + NADP+ -> NADPH + H+ + Prostaglandin_D2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

9alpha,11alpha_Prostaglandin_F2 + NADP+ -> NADPH + Prostaglandin_D2 + H+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

2 NADP+ + trans_Cyclohexa_3,5_diene_1,2_diol -> 2_Hydroxycyclohexa_3,5_diene_1_one + 2 NADPH + 2 H+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + (S)_Indan_1_ol -> Indanone + H+ + NADPH		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Cyclohex_2_en_1_ol + NADP+ -> H+ + NADPH + Cyclohex_2_enone		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

beta_3_Hydroxyhexobarbital + NADP+ -> 3_Oxohexobarbital + NADPH + H+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + 3alpha_Hydroxyhexobarbital -> 3_Oxohexobarbital + NADPH + H+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

(S)_(+)_1,2,3,4_Tetrahydro_1_naphthol + NADP+ -> H+ + (S)_(+)_2,3,4_Trihydro_1_naphtone + NADPH		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + Estradiol_17beta -> Estrone + H+ + NADPH		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + 17alpha,20alpha_Dihydroxypregn_4_en_3_one -> 17alpha_Hydroxyprogesterone + NADPH + H+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

5alpha_Androstane_17beta_ol_3_one + NADP+ -> H+ + 5alpha_Androstane_3,17_dione + NADPH		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

5alpha_Androstane_3alpha,17beta_diol + NADP+ -> 5alpha_Androstane_3alpha_ol_17_one + NADPH + H+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

5beta_Androstane_3alpha,17beta_diol + NADP+ -> NADPH + H+ + 3alpha_Hydroxy_5beta_androstan_17_one		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADP+ + 5beta_Androstane_17beta_ol_3_one -> NADPH + 5beta_Androstane_3,17_dione + H+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

2_Acetylpyridine + NADPH + H+ -> 1_(Pyridin_2_yl)ethanol + NADP+		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
uniprot:Q3MHS3 [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + NADPH + 4_Nitroacetophenone -> NADP+ + 1_(4_Nitrophenyl)ethanol		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 0.1 M Potassium phosphate
PH: 7.4
Temperature: 25
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

NADPH + H+ + Estrone -> NADP+ + Estradiol_17beta		 (( (Vmax * A) ) / (Km + A)) buffer: 160 mM TRIZMA-citrate, 10 mM MgCl2
PH: 7.5
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

H+ + Estrone + NADPH -> NADP+ + Estradiol_17beta		 (( (Vmax * A) ) / (Km + A)) buffer: 160 mM TRIZMA-citrate, 10 mM MgCl2
PH: 7.5
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Estradiol_17beta + NAD+ -> Estrone + H+ + NADH		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 160 mM TRIZMA-citrate, 10 mM MgCl2
PH: 9
Temperature: 37
- [estradiol 17beta-dehydrogenase(Enzyme) wildtype]

Estradiol_17beta + NAD+ -> Estrone + NADH + H+		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 160 mM TRIZMA-citrate, 10 mM MgCl2
PH: 9
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY-7455 allopregnanolone biosynthesis
BioCyc:HUMAN_ILEUDEG-PWY isoleucine degradation
BioCyc:HUMAN_PWY66-378 androgen biosynthesis
BioCyc:META_PWY66-380 estradiol biosynthesis I (via estrone)
BioCyc:META_FAO-PWY fatty acid β-oxidation I
BioCyc:META_ILEUDEG-PWY L-isoleucine degradation I
BioCyc:META_PWY-6074 zymosterol biosynthesis
BioCyc:MOUSE_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:HUMAN_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:HUMAN_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:MOUSE_PWY3DJ-0 isoleucine degradation
BioCyc:MOUSE_PWY66-341 cholesterol biosynthesis I
BioCyc:HUMAN_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:HUMAN_PWY-6074 zymosterol biosynthesis
BioCyc:HUMAN_PWY66-380 estradiol biosynthesis I
BioCyc:META_PWY66-378 androgen biosynthesis
BioCyc:META_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:MOUSE_PWY-5109 2-methylbutyrate biosynthesis
BioCyc:HUMAN_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:HUMAN_FAO-PWY fatty acid β-oxidation
BioCyc:META_PWY-7455 allopregnanolone biosynthesis
BioCyc:META_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:MOUSE_FAO-PWY fatty acid β-oxidation I
BioCyc:MOUSE_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:MOUSE_PWY-5136 fatty acid β-oxidation II (core pathway)
Reactome:R-HSA-9757110 Prednisone ADME
Reactome:R-HSA-9748784 Drug ADME
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-71291 Amino acid and derivative metabolism
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-556833 Metabolism of lipids
Reactome:R-CFA-75105 Fatty acyl-CoA biosynthesis
Reactome:R-HSA-75105 Fatty acyl-CoA biosynthesis
Reactome:R-HSA-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-HSA-70895 Branched-chain amino acid catabolism
Reactome:R-HSA-5362517 Signaling by Retinoic Acid
Reactome:R-HSA-72306 tRNA processing
Reactome:R-HSA-6785470 tRNA processing in the mitochondrion
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-75105 Fatty acyl-CoA biosynthesis
Reactome:R-MMU-8957322 Metabolism of steroids
Reactome:R-MMU-193144 Estrogen biosynthesis
Reactome:R-MMU-70895 Branched-chain amino acid catabolism
Reactome:R-RNO-8978868 Fatty acid metabolism
Reactome:R-RNO-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-RNO-196071 Metabolism of steroid hormones
Reactome:R-RNO-70895 Branched-chain amino acid catabolism
Reactome:R-BTA-70895 Branched-chain amino acid catabolism
Reactome:R-CFA-8978868 Fatty acid metabolism
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-71291 Amino acid and derivative metabolism
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-8978868 Fatty acid metabolism
Reactome:R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Reactome:R-HSA-191273 Cholesterol biosynthesis
Reactome:R-HSA-193144 Estrogen biosynthesis
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-8978868 Fatty acid metabolism
Reactome:R-MMU-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-MMU-196071 Metabolism of steroid hormones
Reactome:R-RNO-8964572 Lipid particle organization
Reactome:R-RNO-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-HSA-6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-5365859 RA biosynthesis pathway
Reactome:R-HSA-8953854 Metabolism of RNA
Reactome:R-HSA-6787450 tRNA modification in the mitochondrion
Reactome:R-MMU-191273 Cholesterol biosynthesis
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-RNO-75105 Fatty acyl-CoA biosynthesis
Reactome:R-RNO-8957322 Metabolism of steroids
Reactome:R-RNO-193144 Estrogen biosynthesis
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-DME-70895 Branched-chain amino acid catabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-8964572 Lipid particle organization
Reactome:R-HSA-2142753 Arachidonate metabolism
Reactome:R-HSA-8957322 Metabolism of steroids
Reactome:R-HSA-196071 Metabolism of steroid hormones
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-72312 rRNA processing
Reactome:R-HSA-8868766 rRNA processing in the mitochondrion
Reactome:R-MMU-8964572 Lipid particle organization
Reactome:R-MMU-6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway)
Reactome:R-RNO-191273 Cholesterol biosynthesis
WikiPathways:WP5287 17q12 copy number variation syndrome
WikiPathways:WP5280 Glucocorticoid biosynthesis
WikiPathways:WP5368 Sulfatase and aromatase pathway
WikiPathways:WP5320 Male steroid hormones in cardiomyocyte energy metabolism
WikiPathways:WP5176 Disorders of bile acid synthesis and biliary transport
WikiPathways:WP4686 Leucine, isoleucine and valine metabolism
WikiPathways:WP4524 Alternative pathway of fetal androgen synthesis
PathBank:SMP0120658 17-beta Hydroxysteroid Dehydrogenase III Deficiency
PathBank:SMP0120794 Mevalonic Aciduria
PathBank:SMP0030406 Androstenedione Metabolism
PathBank:SMP0120440 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120444 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120516 Maple Syrup Urine Disease
PathBank:SMP0120589 Isovaleric Acidemia
PathBank:SMP0120629 Aromatase Deficiency
PathBank:SMP0121057 Bloch Pathway (Cholesterol Biosynthesis)
PathBank:SMP0000032 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0000023 Steroid Biosynthesis
PathBank:SMP0000068 Androgen and Estrogen Metabolism
PathBank:SMP0000173 beta-Ketothiolase Deficiency
PathBank:SMP0000199 Maple Syrup Urine Disease
PathBank:SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000387 CHILD Syndrome
PathBank:SMP0000083 Acetylsalicylic Acid Action Pathway
PathBank:SMP0000087 Rofecoxib Action Pathway
PathBank:SMP0000094 Sulindac Action Pathway
PathBank:SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
PathBank:SMP0000318 Congenital Bile Acid Synthesis Defect Type III
PathBank:SMP0000141 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0000104 Indomethacin Action Pathway
PathBank:SMP0000120 Naproxen Action Pathway
PathBank:SMP0000112 Risedronate Action Pathway
PathBank:SMP0000106 Meloxicam Action Pathway
PathBank:SMP0000508 Cholesteryl Ester Storage Disease
PathBank:SMP0000524 Isovaleric Acidemia
PathBank:SMP0000544 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD)
PathBank:SMP0000568 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD)
PathBank:SMP0000576 21-Hydroxylase Deficiency (CYP21)
PathBank:SMP0000693 Antrafenine Action Pathway
PathBank:SMP0000697 Flurbiprofen Action Pathway
PathBank:SMP0000701 Phenylbutazone Action Pathway
PathBank:SMP0000705 Tiaprofenic Acid Action Pathway
PathBank:SMP0000709 Salicylic Acid Action Pathway
PathBank:SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency
PathBank:SMP0087326 Steroid Biosynthesis
PathBank:SMP0063612 Fatty Acid Elongation In Mitochondria
PathBank:SMP0120685 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0120769 Hypercholesterolemia
PathBank:SMP0120793 Hyper-IgD Syndrome
PathBank:SMP0120439 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency
PathBank:SMP0120443 3-Methylglutaconic Aciduria Type III
PathBank:SMP0120459 beta-Ketothiolase Deficiency
PathBank:SMP0120503 Isovaleric Aciduria
PathBank:SMP0120523 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120588 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0120608 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD)
PathBank:SMP0120632 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD)
PathBank:SMP0000054 Fatty Acid Elongation in Mitochondria
PathBank:SMP0000035 Bile Acid Biosynthesis
PathBank:SMP0000075 Arachidonic Acid Metabolism
PathBank:SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency
PathBank:SMP0000138 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0000140 3-Methylglutaconic Aciduria Type III
PathBank:SMP0000238 Isovaleric Aciduria
PathBank:SMP0000389 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0000319 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0000082 Simvastatin Action Pathway
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000093 Diclofenac Action Pathway
PathBank:SMP0000098 Ketorolac Action Pathway
PathBank:SMP0000314 Congenital Bile Acid Synthesis Defect Type II
PathBank:SMP0000315 Cerebrotendinous Xanthomatosis (CTX)
PathBank:SMP0000102 Bromfenac Action Pathway
PathBank:SMP0000114 Nabumetone Action Pathway
PathBank:SMP0000111 Cerivastatin Action Pathway
PathBank:SMP0000131 Atorvastatin Action Pathway
PathBank:SMP0000511 Wolman Disease
PathBank:SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1)
PathBank:SMP0000692 Antipyrine Action Pathway
PathBank:SMP0000696 Fenoprofen Action Pathway
PathBank:SMP0000700 Lornoxicam Action Pathway
PathBank:SMP0000704 Tolmetin Action Pathway
PathBank:SMP0000708 Salicylate-Sodium Action Pathway
PathBank:SMP0000717 Apparent Mineralocorticoid Excess Syndrome
PathBank:SMP0087353 Retinol Metabolism
PathBank:SMP0087365 Estrone Metabolism
PathBank:SMP0063641 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
PathBank:SMP0063689 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0120684 CHILD Syndrome
PathBank:SMP0120692 Desmosterolosis
PathBank:SMP0120720 Vitamin A Deficiency
PathBank:SMP0120732 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0120792 Cholesteryl Ester Storage Disease
PathBank:SMP0120848 Aromatase Deficiency
PathBank:SMP0120437 17-beta Hydroxysteroid Dehydrogenase III Deficiency
PathBank:SMP0120441 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0120525 Methylmalonic Aciduria
PathBank:SMP0120537 Propionic Acidemia
PathBank:SMP0120586 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis)
PathBank:SMP0000130 Steroidogenesis
PathBank:SMP0000137 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0000200 Methylmalonic Aciduria
PathBank:SMP0000386 Desmosterolosis
PathBank:SMP0000077 Piroxicam Action Pathway
PathBank:SMP0000084 Etodolac Action Pathway
PathBank:SMP0000089 Pravastatin Action Pathway
PathBank:SMP0000095 Alendronate Action Pathway
PathBank:SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
PathBank:SMP0000317 Familial Hypercholanemia (FHCA)
PathBank:SMP0000109 Mefenamic Acid Action Pathway
PathBank:SMP0000289 Diflunisal Action Pathway
PathBank:SMP0000099 Lovastatin Action Pathway
PathBank:SMP0000117 Pamidronate Action Pathway
PathBank:SMP0000116 Valdecoxib Action Pathway
PathBank:SMP0000509 Hyper-IgD Syndrome
PathBank:SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0000565 Aromatase Deficiency
PathBank:SMP0000577 Corticosterone Methyl Oxidase I Deficiency (CMO I)
PathBank:SMP0000650 Doxorubicin Metabolism Pathway
PathBank:SMP0000694 Carprofen Action Pathway
PathBank:SMP0000698 Magnesium Salicylate Action Pathway
PathBank:SMP0000702 Nepafenac Action Pathway
PathBank:SMP0000706 Tenoxicam Action Pathway
PathBank:SMP0000710 Acetaminophen Action Pathway
PathBank:SMP0087260 Retinol Metabolism
PathBank:SMP0087344 Androgen and Estrogen Metabolism
PathBank:SMP0087364 Androstenedione Metabolism
PathBank:SMP0063594 Androgen and Estrogen Metabolism
PathBank:SMP0120735 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0120795 Wolman Disease
PathBank:SMP0030880 Estrone Metabolism
PathBank:SMP0120442 3-Methylglutaconic Aciduria Type I
PathBank:SMP0120587 3-Hydroxyisobutyric Aciduria
PathBank:SMP0000236 Propionic Acidemia
PathBank:SMP0000139 3-Methylglutaconic Aciduria Type I
PathBank:SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0000353 Leukotriene C4 Synthesis Deficiency
PathBank:SMP0000079 Ibandronate Action Pathway
PathBank:SMP0000085 Ketoprofen Action Pathway
PathBank:SMP0000092 Rosuvastatin Action Pathway
PathBank:SMP0000096 Celecoxib Action Pathway
PathBank:SMP0000480 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
PathBank:SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency
PathBank:SMP0000316 Zellweger Syndrome
PathBank:SMP0000209 Hypercholesterolemia
PathBank:SMP0000101 Suprofen Action Pathway
PathBank:SMP0000113 Oxaprozin Action Pathway
PathBank:SMP0000107 Zoledronate Action Pathway
PathBank:SMP0000119 Fluvastatin Action Pathway
PathBank:SMP0000510 Mevalonic Aciduria
PathBank:SMP0000522 3-Hydroxyisobutyric Aciduria
PathBank:SMP0000566 17-alpha-Hydroxylase Deficiency (CYP17)
PathBank:SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II)
PathBank:SMP0000635 Valproic Acid Metabolism Pathway
PathBank:SMP0000695 Etoricoxib Action Pathway
PathBank:SMP0000699 Lumiracoxib Action Pathway
PathBank:SMP0000703 Trisalicylate-Choline Action Pathway
PathBank:SMP0000707 Salsalate Action Pathway
PathBank:SMP0000720 27-Hydroxylase Deficiency
PathBank:SMP0087251 Androgen and Estrogen Metabolism
PathBank:SMP0087271 Androstenedione Metabolism
PathBank:SMP0063696 Estrone Metabolism