Congenital Bile Acid Synthesis Defect Type III

Metabolites

25-Hydroxycholesterol

Formula: C27H46O2 (402.34976159999997)

CAS ID: 2140-46-7

3'-AMP

Formula: C10H14N5O7P (347.06308240000004)

CAS ID: 84-21-9

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

Cerebrosterol

Formula: C27H46O2 (402.34976159999997)

CAS ID: 474-73-7

Chenodeoxycholate

Formula: C24H40O4 (392.29264400000005)

CAS ID: 474-25-9

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

Cholic acid

Formula: C24H40O5 (408.28755900000004)

CAS ID: 81-25-4

Choloyl-CoA

Formula: C45H74N7O20P3S (1157.3921994000002)

CAS ID: 6050-48-2

Deoxycholic acid

Formula: C24H40O4 (392.29264400000005)

CAS ID: 83-44-3

Glycodeoxycholate

Formula: C26H43NO5 (449.31410680000005)

CAS ID: 360-65-6

Glycolithocholate

Formula: C26H43NO4 (433.31919180000006)

CAS ID: 474-74-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hexadecanoic acid

Formula: C16H32O2 (256.2402172)

CAS ID: 57-10-3

Lithocholic acid

Formula: C24H40O3 (376.297729)

CAS ID: 434-13-9

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Taurine

Formula: C2H7NO3S (125.0146632)

CAS ID: 107-35-7

Taurocholate

Formula: C26H45NO7S (515.291658)

CAS ID: 81-24-3

Taurodeoxycholate

Formula: C26H45NO6S (499.29674300000005)

CAS ID: 516-50-7

27-Hydroxycholesterol

Formula: C27H46O2 (402.34976159999997)

CAS ID: 20380-11-4

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.181 cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase
1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase
1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase 3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase
1.1.1.225 chlordecone reductase chlordecone-alcohol:NADP+ 2-oxidoreductase
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol:NAD(P)+ 17-oxidoreductase
1.14.14.139 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase 5beta-cholestane-3alpha,7alpha-diol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating)
1.14.14.23 cholesterol 7alpha-monooxygenase cholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (7alpha-hydroxylating)
1.14.14.25 cholesterol 24-hydroxylase cholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating)
1.14.14.26 24-hydroxycholesterol 7alpha-hydroxylase (24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase cholest-5-ene-3beta,25/26-diol,[NADPH-hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)
1.14.15.15 cholestanetriol 26-monooxygenase 5beta-cholestane-3alpha,7alpha,12alpha-triol,adrenodoxin:oxygen oxidoreductase (26-hydroxylating)
1.14.99.38 cholesterol 25-monooxygenase cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating)
1.17.99.3 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating)
1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase
2.3.1.155 acetyl-CoA C-myristoyltransferase myristoyl-CoA:acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase acyl-CoA:acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
2.3.1.65 bile acid-CoA:amino acid N-acyltransferase choloyl-CoA:glycine N-choloyltransferase
3.1.1.13 sterol esterase steryl-ester acylhydrolase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase
3.1.2.27 choloyl-CoA hydrolase choloyl-CoA hydrolase
4.2.1.107 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming]
4.2.1.119 enoyl-CoA hydratase 2 (3R)-3-hydroxyacyl-CoA hydro-lyase
5.1.99.4 alpha-methylacyl-CoA racemase 2-Methylacyl-CoA 2-epimerase
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)
6.2.1.7 cholate-CoA ligase cholate:CoA ligase (AMP-forming)


Proteins

Protein ID name full name