数据之源，洞见之始

cholesterol biosynthesis I

Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Mol Endocrinol. 2003 Sep;17(9):1715–25. doi: 10.1210/me.2002-0436. PMID: 12829805.; Herman GE. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet. 2003 Apr 01;12 Spec No 1():R75–88. doi: 10.1093/hmg/ddg072. PMID: 12668600.; Mo C, Valachovic M, Randall SK, Nickels JT, Bard M. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9739–44. PMID: 12119386; PMCID: PMC124998.; Blagg BS, Jarstfer MB, Rogers DH, Poulter CD. Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene. J Am Chem Soc. 2002 Jul 31;124(30):8846–53. doi: 10.1021/ja020411a. PMID: 12137537.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Waterham HR, Koster J, Romeijn GJ, Hennekam RCM, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJA. Mutations in the 3ß-Hydroxysterol ?24-Reductase Gene Cause Desmosterolosis, an Autosomal Recessive Disorder of Cholesterol Biosynthesis. The American Journal of Human Genetics. 2001 Oct;69(4):685–94. doi: 10.1086/323473.; Vance DE, Van den Bosch H. Cholesterol in the year 2000. Biochim Biophys Acta. 2000 Dec 15;1529(1-3):1–8. doi: 10.1016/s1388-1981(00)00133-5. PMID: 11111073.; Taton M, Husselstein T, Benveniste P, Rahier A. Role of highly conserved residues in the reaction catalyzed by recombinant Delta7-sterol-C5(6)-desaturase studied by site-directed mutagenesis. Biochemistry. 2000 Feb 01;39(4):701–11. doi: 10.1021/bi991467t. PMID: 10651635.; Knopp RH. Drug treatment of lipid disorders. N Engl J Med. 1999 Aug 12;341(7):498–511. doi: 10.1056/nejm199908123410707. PMID: 10441607.; Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 01;326 ( Pt 2)():609–16. PMID: 9291139; PMCID: PMC1218712.; Bloch K. Sterol molecule: structure, biosynthesis, and function. Steroids. 1992 Aug;57(8):378–83. doi: 10.1016/0039-128x(92)90081-j. PMID: 1519268.; Fischer RT, Trzaskos JM, Magolda RL, Ko SS, Brosz CS, Larsen B. Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate. Journal of Biological Chemistry. 1991 Apr;266(10):6124–32. doi: 10.1016/s0021-9258(18)38093-1.; Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature. 1990 Feb 01;343(6257):425–30. doi: 10.1038/343425a0. PMID: 1967820.; Reinhart MP, Billheimer JT, Faust JR, Gaylor JL. Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. Journal of Biological Chemistry. 1987 Jul;262(20):9649–55. doi: 10.1016/s0021-9258(18)47983-5.; Shafiee A, Trzaskos JM, Paik YK, Gaylor JL. Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates. Journal of Lipid Research. 1986 Nov;27(1):1–10. doi: 10.1016/s0022-2275(20)38858-1.; Paik YK, Billheimer JT, Magolda RL, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase. Journal of Biological Chemistry. 1986 May;261(14):6470–7. doi: 10.1016/s0021-9258(19)84586-6.; Kawata S, Trzaskos JM, Gaylor JL. Affinity chromatography of microsomal enzymes on immobilized detergent-solubilized cytochrome b5. Journal of Biological Chemistry. 1986 Mar;261(8):3790–9. doi: 10.1016/s0021-9258(17)35717-4.; Kawata S, Trzaskos JM, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Purification and characterization of delta 7-sterol 5-desaturase of rat liver microsomes. Journal of Biological Chemistry. 1985 Jun;260(11):6609–17. doi: 10.1016/s0021-9258(18)88825-1.; Paik YK, Trzaskos JM, Shafiee A, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. Journal of Biological Chemistry. 1984 Nov;259(21):13413–23. doi: 10.1016/s0021-9258(18)90710-6.; Trzaskos JM, Bowen WD, Shafiee A, Fischer RT, Gaylor JL. Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. Journal of Biological Chemistry. 1984 Nov;259(21):13402–12. doi: 10.1016/s0021-9258(18)90709-x.; Schroepfer GJ. Sterol biosynthesis. Annu Rev Biochem. 1982;51():555–85. doi: 10.1146/annurev.bi.51.070182.003011. PMID: 6810750.; Billheimer JT, Alcorn M, Gaylor JL. Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis. Archives of Biochemistry and Biophysics. 1981 Oct;211(1):430–8. doi: 10.1016/0003-9861(81)90474-4.; Fukushima H, Grinstead GF, Gaylor JL. Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. Journal of Biological Chemistry. 1981 May;256(10):4822–6. doi: 10.1016/s0021-9258(19)69327-0.; Gaylor JL, Miyake Y, Yamano T. Stoichiometry of 4-methyl sterol oxidase of rat liver microsomes. Journal of Biological Chemistry. 1975 Sep;250(18):7159–67. doi: 10.1016/s0021-9258(19)40923-x.; Bechtold MM, Delwiche CV, Comal K, Gaylor JL. Investigation of the component reactions of oxidative sterol demethylation. Role of an endogenous microsomal source of reducing equivalents. J Biol Chem. 1972 Dec 10;247(23):7650–6. PMID: 4404598.; Rahimtula AD, Gaylor JL. Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase. J Biol Chem. 1972 Jan 10;247(1):9–15. PMID: 4401584.; Miller WL, Brady DR, Gaylor JL. Investigation of the component reactions of oxidative demethylation of sterols. Metabolism of 4 -hydroxymethyl steroids. J Biol Chem. 1971 Aug 25;246(16):5147–53. PMID: 4398294.; Miller WL, Gaylor JL. Investigation of the component reactions of oxidative sterol demethylation. Oxidation of a 4,4-dimethyl sterol to a 4 beta-methyl-4 alpha-carboxylic acid during cholesterol biosynthesis. J Biol Chem. 1970 Oct 25;245(20):5375–81. PMID: 4394229.; Yamamoto S, Bloch K. Studies on Squalene Epoxidase of Rat Liver. Journal of Biological Chemistry. 1970 Apr;245(7):1670–4. doi: 10.1016/s0021-9258(19)77144-0.; Miller WL, Kalafer ME, Gaylor JL, Delwiche CV. Investigation of the Component Reactions of Oxidative Sterol Demethylation. Study of the Aerobic and Anaerobic Processes^*. Biochemistry. 1967 Sep 01;6(9):2673–8. doi: 10.1021/bi00861a005.; Dean PDG, de Montellano PRO, Bloch K, Corey EJ. A Soluble 2,3-Oxidosqualene Sterol Cyclase. Journal of Biological Chemistry. 1967 Jun;242(12):3014–5. doi: 10.1016/s0021-9258(18)99606-7.; Bloch K. The biological synthesis of cholesterol. Science. 1965 Oct 01;150(3692):19–28. doi: 10.1126/science.150.3692.19. PMID: 5319508.