Prednisone ADME
Mazzarino M, Piantadosi C, Comunità F, de la Torre X, Botrè F. Urinary excretion profile of prednisone and prednisolone after different administration routes. Drug Test Anal. 2019 Nov;11(11-12):1601–14. doi: 10.1002/dta.2733. PMID: 31701669.; Matabosch X, Pozo OJ, Pérez-Mañá C, Papaseit E, Segura J, Ventura R. Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS. J Mass Spectrom. 2015 Mar;50(3):633–42. doi: 10.1002/jms.3571. PMID: 25800201.; Vogt M, Derendorf H, Krämer J, Junginger HE, Midha KK, Shah VP, Stavchansky S, Dressman JB, Barends DM. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Prednisone. Journal of Pharmaceutical Sciences. 2007 Jun;96(6):1480–9. doi: 10.1002/jps.20817.; Diederich S, Eigendorff E, Burkhardt P, Quinkler M, Bumke-Vogt C, Rochel M, Seidelmann D, Esperling P, Oelkers W, Bähr V. 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids. J Clin Endocrinol Metab. 2002 Dec;87(12):5695–701. doi: 10.1210/jc.2002-020970. PMID: 12466373.; Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM. Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab. 1998 Apr;83(4):1325–35. doi: 10.1210/jcem.83.4.4706. PMID: 9543163.; Jamieson PM, Chapman KE, Edwards CR, Seckl JR. 11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology. 1995 Nov;136(11):4754–61. doi: 10.1210/endo.136.11.7588203. PMID: 7588203.; Pickup ME. Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1979 Mar;4(2):111–28. doi: 10.2165/00003088-197904020-00004. PMID: 378499.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.- | |||
| 1.1.1.112 | indanol dehydrogenase | indan-1-ol:NAD(P)+ 1-oxidoreductase | |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase | 11beta-hydroxysteroid:NADP+ 11-oxidoreductase | |
| 1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase | 20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase | |
| 1.1.1.201 | 7beta-hydroxysteroid dehydrogenase (NADP+) | 7beta-hydroxysteroid:NADP+ 7-oxidoreductase | |
| 1.1.1.209 | 3(or 17)alpha-hydroxysteroid dehydrogenase | 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase | |
| 1.1.1.210 | 3beta(or 20alpha)-hydroxysteroid dehydrogenase | 3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase | |
| 1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase | 3beta-hydroxysteroid:NADP+ 3-oxidoreductase | |
| 1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase | 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase | |
| 1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase | 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase | |
| 1.1.1.53 | 3alpha(or 20beta)-hydroxysteroid dehydrogenase | 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase | |
| 1.1.1.62 | 17beta-estradiol 17-dehydrogenase | 17beta-estradiol:NAD(P)+ 17-oxidoreductase | |
| 1.14.14.1 | unspecific monooxygenase | substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) | |
| 1.14.14.55 | quinine 3-monooxygenase | quinine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase | |
| 1.14.14.56 | 1,8-cineole 2-exo-monooxygenase | 1,8-cineole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (2-exo-hydroxylating) | |
| 1.14.14.73 | albendazole monooxygenase (sulfoxide-forming) | albendazole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (sulfoxide-forming) | |
| 1.3.1.20 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase | |
| 7.6.2.1 | P-type phospholipid transporter | ATP phosphohydrolase (P-type, phospholipid-flipping) | |
| 7.6.2.2 | ABC-type xenobiotic transporter | ATP phosphohydrolase (ABC-type, xenobiotic-exporting) |
Proteins
| Protein ID | name | full name |
|---|