fatty acid β-oxidation I

Campbell JW, Morgan-Kiss RM, E. Cronan J. A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic ß-oxidation pathway. Molecular Microbiology. 2003 Jan 15;47(3):793–805. doi: 10.1046/j.1365-2958.2003.03341.x.

Metabolites

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

N-Ethylmaleimide

Formula: C6H7NO2 (125.0476762)

CAS ID: 128-53-0

Thiocyanate

Formula: CNS (57.975145999999995)

CAS ID: 302-04-5

iodoacetamide

Formula: C2H4INO (184.9337644)

CAS ID: 144-48-9

Perchloric acid

Formula: ClHO4 (99.95633760000001)

CAS ID: 7601-90-3

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
3.1.2.-
1.1.1.159 7alpha-hydroxysteroid dehydrogenase 7alpha-hydroxysteroid:NAD+ 7-oxidoreductase
1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol:NAD(P)+ 17-oxidoreductase
1.3.8.7 medium-chain acyl-CoA dehydrogenase medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
1.3.8.8 long-chain acyl-CoA dehydrogenase long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
2.3.1.155 acetyl-CoA C-myristoyltransferase myristoyl-CoA:acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase acyl-CoA:acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase acetyl-CoA:acetyl-CoA C-acetyltransferase
3.1.2.1 acetyl-CoA hydrolase acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase
4.2.1.17 enoyl-CoA hydratase (3S)-3-hydroxyacyl-CoA hydro-lyase
5.1.2.3 3-hydroxybutyryl-CoA epimerase 3-hydroxybutanoyl-CoA 3-epimerase
5.3.3.8 DELTA3-DELTA2-enoyl-CoA isomerase (3Z/3E)-alk-3-enoyl-CoA (2E)-isomerase
6.2.1.15 arachidonate-CoA ligase arachidonate:CoA ligase (AMP-forming)
6.2.1.2 medium-chain acyl-CoA ligase medium-chain fatty acid:CoA ligase (AMP-forming)
6.2.1.24 phytanate-CoA ligase phytanate:CoA ligase (AMP-forming)
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)
6.2.1.7 cholate-CoA ligase cholate:CoA ligase (AMP-forming)


Proteins

Protein ID name full name
P21151 fadA 3-ketoacyl-CoA thiolase FadA
P21177 fadB Fatty acid oxidation complex subunit alpha
P38135 fadK Medium-chain fatty-acid--CoA ligase
P69451 fadD Long-chain-fatty-acid--CoA ligase
P76503 fadI 3-ketoacyl-CoA thiolase FadI
P77399 fadJ Fatty acid oxidation complex subunit alpha
Q47146 fadE Acyl-coenzyme A dehydrogenase