zymosterol biosynthesis
Mo C, Valachovic M, Randall SK, Nickels JT, Bard M. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9739–44. PMID: 12119386; PMCID: PMC124998.; Parks LW, Casey WM. Physiological implications of sterol biosynthesis in yeast. Annu Rev Microbiol. 1995;49():95–116. doi: 10.1146/annurev.mi.49.100195.000523. PMID: 8561481.
Metabolites
4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
Formula: C29H46O (410.3548466)
CAS ID: 64284-64-6
4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol
Formula: C29H46O2 (426.34976159999997)
CAS ID: 1028833-06-8
4α-hydroxymethyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol
Formula: C29H48O2 (428.36541079999995)
CAS ID: 616897-75-7
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.170 | 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) | 3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating) | |
| 1.1.1.210 | 3beta(or 20alpha)-hydroxysteroid dehydrogenase | 3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase | |
| 1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase | 3beta-hydroxysteroid:NADP+ 3-oxidoreductase | |
| 1.1.1.62 | 17beta-estradiol 17-dehydrogenase | 17beta-estradiol:NAD(P)+ 17-oxidoreductase | |
| 1.14.14.154 | sterol 14alpha-demethylase | sterol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) | |
| 1.3.1.70 | DELTA14-sterol reductase | 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ DELTA14-oxidoreductase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P10614 | ERG11 | Lanosterol 14-alpha demethylase CYP51 |
| P32462 | ERG24 | Delta(14)-sterol reductase ERG24 |
| P53199 | ERG26 | Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating |
| Q12452 | ERG27 | 3-keto-steroid reductase ERG27 |