Alternative pathway of fetal androgen synthesis

Moore RJ, Griffin JE, Wilson JD. Diminished 5alpha-reductase activity in extracts of fibroblasts cultured from patients with familial incomplete male pseudohermaphroditism, type 2. Journal of Biological Chemistry. 1975 Sep;250(18):7168–72. doi: 10.1016/s0021-9258(19)40924-1.

Metabolites

17alpha-Hydroxyprogesterone

Formula: C21H30O3 (330.21948299999997)

CAS ID: 68-96-2

5alpha-Androstane-3,17-dione

Formula: C19H28O2 (288.2089188)

CAS ID: 846-46-8

Androstenedione

Formula: C19H26O2 (286.1932696)

CAS ID: 63-05-8

Androsterone

Formula: C19H30O2 (290.224568)

CAS ID: 53-41-8

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

Dehydroepiandrosterone

Formula: C19H28O2 (288.2089188)

CAS ID: 53-43-0

Dihydrotestosterone

Formula: C19H30O2 (290.224568)

CAS ID: 521-18-6

Isopregnanolone

Formula: C21H34O2 (318.2558664)

CAS ID: 516-55-2

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

Progesterone

Formula: C21H30O2 (314.224568)

CAS ID: 57-83-0

Testosterone

Formula: C19H28O2 (288.2089188)

CAS ID: 58-22-0

(20R)-17,20-dihydroxypregn-4-en-3-one

Formula: C21H32O3 (332.23513219999995)

CAS ID: 1662-06-2

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.105 all-trans-retinol dehydrogenase (NAD+) all-trans retinol:NAD+ oxidoreductase
1.1.1.112 indanol dehydrogenase indan-1-ol:NAD(P)+ 1-oxidoreductase
1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase 3beta-hydroxy-DELTA5-steroid:NAD+ 3-oxidoreductase
1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase 3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol:NAD(P)+ 17-oxidoreductase
1.14.14.19 steroid 17alpha-monooxygenase steroid,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
1.14.14.32 17alpha-hydroxyprogesterone deacetylase 17alpha-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) 3-oxo-5alpha-steroid:NADP+ DELTA4-oxidoreductase
1.6.2.4 NADPH-hemoprotein reductase NADPH:hemoprotein oxidoreductase
5.3.3.1 steroid DELTA-isomerase 3-oxosteroid DELTA5-DELTA4-isomerase


Proteins

Protein ID name full name