Branched-chain amino acid catabolism

Neinast M, Murashige D, Arany Z. Branched Chain Amino Acids. Annu. Rev. Physiol. 2019 Feb 10;81(1):139–64. doi: 10.1146/annurev-physiol-020518-114455.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

(E)-2-methylcrotonoyl-CoA

Formula: C26H38N7O17P3S (845.1257688000001)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

(S)-3-hydroxyisobutyrate

Formula: C4H7O3 (103.0395172)

CAS ID:

(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)

Formula: C27H39N7O20P3S (906.1183384)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

thiamine(1+) diphosphate(3-)

Formula: C12H16N4O7P2S (422.0214926)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.31 3-hydroxyisobutyrate dehydrogenase 3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase 3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol:NAD(P)+ 17-oxidoreductase
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating) 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
6.4.1.4 methylcrotonoyl-CoA carboxylase 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)


Proteins

Protein ID name full name