Fatty acyl-CoA biosynthesis

Beld J, Lee DJ, Burkart MD. Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering. Mol Biosyst. 2015 Jan;11(1):38–59. PMID: 25360565; PMCID: PMC4276719.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

oxaloacetate(2-)

Formula: C4H2O5 (129.9902242)

CAS ID: 149-63-3

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

citrate(3-)

Formula: C6H5O7 (189.00352800000002)

CAS ID: 126-44-3

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.n12
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase (3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol:NAD(P)+ 17-oxidoreductase
1.14.19.1 stearoyl-CoA 9-desaturase stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)
1.6.5.10 NADPH dehydrogenase (quinone) NADPH:(quinone-acceptor) oxidoreductase
2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing)
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase acetyl-CoA:[acyl-carrier protein] S-acetyltransferase
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase malonyl-CoA:[acyl-carrier protein] S-malonyltransferase
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I acyl-[acyl-carrier protein]:malonyl-[acyl-carrier protein] C-acyltransferase (decarboxylating)
2.3.1.85 fatty-acid synthase system acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
2.3.3.8 ATP citrate synthase acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase oleoyl-[acyl-carrier protein] hydrolase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase palmitoyl[protein] hydrolase
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming)
6.2.1.15 arachidonate-CoA ligase arachidonate:CoA ligase (AMP-forming)
6.2.1.24 phytanate-CoA ligase phytanate:CoA ligase (AMP-forming)
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)
6.2.1.7 cholate-CoA ligase cholate:CoA ligase (AMP-forming)
6.2.1.76 malonate-CoA ligase malonate:CoA ligase (AMP-forming)
6.4.1.2 acetyl-CoA carboxylase acetyl-CoA:hydrogencarbonate ligase (ADP-forming)


Proteins

Protein ID name full name