estradiol biosynthesis I (via estrone)

Thompson EA, Siiteri PK. The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization. Journal of Biological Chemistry. 1974 Sep;249(17):5373–8. doi: 10.1016/s0021-9258(20)79736-x.

Metabolites

19-Hydroxyandrost-4-ene-3,17-dione

Formula: C19H26O3 (302.1881846)

CAS ID: 510-64-5

Androstenedione

Formula: C19H26O2 (286.1932696)

CAS ID: 63-05-8

Estradiol-17beta

Formula: C18H24O2 (272.17762039999997)

CAS ID: 50-28-2

Estrone

Formula: C18H22O2 (270.1619712)

CAS ID: 53-16-7

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6



Enzyme

EC Number name full name note
1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase 3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase
1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase 3beta-hydroxysteroid:NADP+ 3-oxidoreductase
1.1.1.62 17beta-estradiol 17-dehydrogenase 17beta-estradiol:NAD(P)+ 17-oxidoreductase
1.14.14.14 aromatase testosterone monooxygenase (17beta-estradiol-forming)


Proteins

Protein ID name full name