Phase I - Functionalization of compounds
Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Metabolites
(24S)-Cholest-5-ene-3beta,7alpha,24-triol
Formula: C27H46O3 (418.34467659999996)
CAS ID: 245523-67-5
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide
Formula: C11H16N2O5 (256.1059166)
CAS ID: 19132-12-8
4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
Formula: C29H46O (410.3548466)
CAS ID: 64284-64-6
(24S)-1alpha,24,25-trihydroxyvitamin D3 / (24S)-1alpha,24,25-trihydroxycholecalciferol
Formula: C27H44O4 (432.3239424)
CAS ID: 56142-95-1
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.- | |||
| 1.1.1.1 | alcohol dehydrogenase | alcohol:NAD+ oxidoreductase | |
| 1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) | all-trans retinol:NAD+ oxidoreductase | |
| 1.1.1.184 | carbonyl reductase (NADPH) | secondary-alcohol:NADP+ oxidoreductase | |
| 1.1.1.284 | S-(hydroxymethyl)glutathione dehydrogenase | S-(hydroxymethyl)glutathione:NAD+ oxidoreductase | |
| 1.1.1.66 | omega-hydroxydecanoate dehydrogenase | 10-hydroxydecanoate:NAD+ 10-oxidoreductase | |
| 1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) | 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase | |
| 1.14.13.148 | trimethylamine monooxygenase | N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming) | |
| 1.14.13.32 | albendazole monooxygenase | albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming) | |
| 1.14.13.8 | flavin-containing monooxygenase | N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming) | |
| 1.14.14.1 | unspecific monooxygenase | substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) | |
| 1.14.14.139 | 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase | 5beta-cholestane-3alpha,7alpha-diol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating) | |
| 1.14.14.14 | aromatase | testosterone monooxygenase (17beta-estradiol-forming) | |
| 1.14.14.154 | sterol 14alpha-demethylase | sterol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving) | |
| 1.14.14.16 | steroid 21-monooxygenase | steroid,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating) | |
| 1.14.14.24 | vitamin D 25-hydroxylase | calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating) | |
| 1.14.14.25 | cholesterol 24-hydroxylase | cholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating) | |
| 1.14.14.26 | 24-hydroxycholesterol 7alpha-hydroxylase | (24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) | |
| 1.14.14.79 | docosahexaenoic acid omega-hydroxylase | docosahexaenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate forming) | |
| 1.14.14.80 | long-chain fatty acid omega-monooxygenase | long-chain fatty acid,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating) | |
| 1.14.15.15 | cholestanetriol 26-monooxygenase | 5beta-cholestane-3alpha,7alpha,12alpha-triol,adrenodoxin:oxygen oxidoreductase (26-hydroxylating) | |
| 1.14.15.16 | vitamin D3 24-hydroxylase | calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating) | |
| 1.14.15.18 | calcidiol 1-monooxygenase | calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating) | |
| 1.14.15.4 | steroid 11beta-monooxygenase | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating) | |
| 1.14.15.5 | corticosterone 18-monooxygenase | corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating) | |
| 1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) | cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving) | |
| 1.14.99.1 | prostaglandin-endoperoxide synthase | (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase | |
| 1.18.1.6 | adrenodoxin-NADP+ reductase | adrenodoxin:NADP+ oxidoreductase | |
| 1.2.1.19 | aminobutyraldehyde dehydrogenase | 4-aminobutanal:NAD+ 1-oxidoreductase | |
| 1.2.1.28 | benzaldehyde dehydrogenase (NAD+) | benzaldehyde:NAD+ oxidoreductase | |
| 1.2.1.3 | aldehyde dehydrogenase (NAD+) | aldehyde:NAD+ oxidoreductase | |
| 1.2.1.36 | retinal dehydrogenase | retinal:NAD+ oxidoreductase | |
| 1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] | aldehyde:NAD(P)+ oxidoreductase | |
| 1.4.3.21 | primary-amine oxidase | primary-amine:oxygen oxidoreductase (deaminating) | |
| 1.4.3.22 | diamine oxidase | histamine:oxygen oxidoreductase (deaminating) | |
| 1.4.3.4 | monoamine oxidase | amine:oxygen oxidoreductase (deaminating) | |
| 1.5.3.13 | N1-acetylpolyamine oxidase | N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming) | |
| 1.5.3.16 | spermine oxidase | spermidine:oxygen oxidoreductase (spermidine-forming) | |
| 1.6.2.2 | cytochrome-b5 reductase | NADH:ferricytochrome-b5 oxidoreductase | |
| 1.6.5.10 | NADPH dehydrogenase (quinone) | NADPH:(quinone-acceptor) oxidoreductase | |
| 2.3.1.48 | histone acetyltransferase | acetyl-CoA:[protein]-L-lysine acetyltransferase | |
| 3.1.1.3 | triacylglycerol lipase | triacylglycerol acylhydrolase | |
| 3.3.2.9 | microsomal epoxide hydrolase | cis-stilbene-oxide hydrolase | |
| 4.2.1.152 | hydroperoxy icosatetraenoate dehydratase | hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming) | |
| 5.3.99.3 | prostaglandin-E synthase | (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase | |
| 5.3.99.5 | thromboxane-A synthase | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase | |
| 6.2.1.1 | acetate-CoA ligase | acetate:CoA ligase (AMP-forming) | |
| 6.2.1.17 | propionate-CoA ligase | propanoate:CoA ligase (AMP-forming) |
Proteins
| Protein ID | name | full name |
|---|