Metabolite Card
Formula: C15H12N2O2 (252.0899)
SMILES: O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC=CC=C1
Synonyms [en]
phenytoin; Dilantin; Phenytoine; Diphenylhydantoin; Fenitoina; Phenytoinum
Last reviewed on 2024-06-28.
Cite this Page
Phenytoin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000016192). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [PubChem]
DBLinks
- CAS Registry Number: 57-41-0
- PubChem CID: 1775
- ChEBI: 8107
- HMDB: HMDB0014397
- LipidMaps:
- KEGG: C07443
- BioCyc: CPD-16703
- NCBI MeSH: Phenytoin
- Wikipedia: Phenytoin
Other DBLinks
- CAS Registry Number: 57-41-0
- CAS Registry Number: 630-93-3
- CAS Registry Number: BRD-K55930204-236-11-0
- PubChem: 1775
- ChEBI: ChEBI:8107
- HMDB: HMDB0014397
- KEGG: C07443
- BioCyc: CPD-16703
- NCBI MeSH: Phenytoin
- Wikipedia: Phenytoin
- DrugBank: DB00252
- RefMet: RM0005659
- MoNA: CCMSLIB00000078503
- MoNA: EQ331901
- MoNA: EQ331902
- MoNA: EQ331903
- MoNA: EQ331904
- MoNA: EQ331905
- MoNA: EQ331906
- MoNA: EQ331951
- MoNA: EQ331952
- MoNA: EQ331953
- MoNA: EQ331954
- MoNA: EQ331955
- MoNA: EQ331956
- MoNA: HMDB0014397_c_ms_100086
- MoNA: HMDB0014397_c_ms_100087
- MoNA: HMDB0014397_c_ms_100088
- MoNA: HMDB0014397_c_ms_100089
- MoNA: HMDB0014397_c_ms_100090
- MoNA: JP002791
- MoNA: JP007973
- MoNA: JP007980
- MoNA: JP007986
- MoNA: LU082751
- MoNA: LU082752
- MoNA: LU082753
- MoNA: LU082754
- MoNA: LU082755
- MoNA: LU082756
- MoNA: LU092051
- MoNA: LU092052
- MoNA: LU092053
- MoNA: LU092054
- MoNA: LU092055
- MoNA: LU092056
- MoNA: WA001884
- MoNA: WA001885
- MoNA: WA001886
- MoNA: WA001887
- MoNA: WA001888
- Metlin: METLIN_1847
- Coconut NaturalProduct: CNP0354634.0
- Coconut NaturalProduct: CNP0436724.0
Class / Ontology
- WishartLab ClassyFire: [Imidazolidines] Imidazolidines
- RefMet: [Imidazolidines] Imidazolidines
- ChEBI: [CHEBI:8107] phenytoin
- Coconut NaturalProduct: [Anthranilic acid alkaloids] Anthranilic acid alkaloids
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| Reactome:R-BTA-1430728 | Metabolism |
| Reactome:R-BTA-211945 | Phase I - Functionalization of compounds |
| Reactome:R-BTA-211981 | Xenobiotics |
| Reactome:R-CEL-211859 | Biological oxidations |
| Reactome:R-CEL-211981 | Xenobiotics |
| Reactome:R-DDI-211859 | Biological oxidations |
| Reactome:R-DDI-211981 | Xenobiotics |
| Reactome:R-HSA-211859 | Biological oxidations |
| Reactome:R-MMU-1430728 | Metabolism |
| Reactome:R-MMU-211859 | Biological oxidations |
| Reactome:R-RNO-211945 | Phase I - Functionalization of compounds |
| Reactome:R-RNO-211981 | Xenobiotics |
| Reactome:R-SSC-211945 | Phase I - Functionalization of compounds |
| Reactome:R-SSC-211981 | Xenobiotics |
| Reactome:R-BTA-211859 | Biological oxidations |
| Reactome:R-RNO-211859 | Biological oxidations |
| Reactome:R-SSC-1430728 | Metabolism |
| Reactome:R-SSC-211859 | Biological oxidations |
| Reactome:R-BTA-211897 | Cytochrome P450 - arranged by substrate type |
| Reactome:R-CEL-211945 | Phase I - Functionalization of compounds |