all-trans-4-Hydroxyretinoic acid (BioCAD00000006114)

blood urine kidney liver

Metabolite Card

Formula: C20H28O3 (316.2038)
SMILES: C\C(\C=C\C1=C(C)C(O)CCC1(C)C)=C/C=C/C(/C)=C/C(O)=O

Synonyms [en]

all-trans-4-Hydroxyretinoic acid; 4-Hydroxy-(7E,9E,11E,13E)-retinoic acid; (2E,4E,6E,8E)-9-(3-hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid; (7E,9E,11E,13E)-4-hydroxyretinoic acid; 4-hydroxy-all-trans-retinoic acid; 4-hydroxyretinoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

all-trans-4-Hydroxyretinoic acid. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000006114). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

4-Hydroxyretinoic acid is an NADPH-dependent hydroxylation metabolite of retinoic acid in the microsomes, via the cytochrome P-450 system. Retinoic acid is an activated metabolite of retinol that supports the systemic functions of vitamin A in vivo. (PMID: 1538719, 1932598, 2851384).

Cytoplasm Extracellular Membrane Nucleus
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 66592-72-1
  • CAS Registry Number: 75281-25-3
  • PubChem: 102461799
  • PubChem: 6438629
  • ChEBI: ChEBI:63795
  • HMDB: HMDB0006254
  • LipidMaps: LMPR01090025
  • KEGG: C16677
  • NCBI MeSH: 4-hydroxyretinoic acid
  • Metlin: METLIN_2281

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R08392 1.14.14.1 C00777 + C03024 + C00007<=>C16677 + C03161 + C00001
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-211945 Phase I - Functionalization of compounds
Reactome:R-CEL-211859 Biological oxidations
Reactome:R-CFA-162582 Signaling Pathways
Reactome:R-CFA-5362517 Signaling by Retinoic Acid
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-211958 Miscellaneous substrates
Reactome:R-DRE-5365859 RA biosynthesis pathway
Reactome:R-DRE-211897 Cytochrome P450 - arranged by substrate type
Reactome:R-DRE-211916 Vitamins
Reactome:R-DDI-211859 Biological oxidations
Reactome:R-GGA-5362517 Signaling by Retinoic Acid
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-5362517 Signaling by Retinoic Acid
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-RNO-211945 Phase I - Functionalization of compounds
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
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