EC: 1.2.1.19

aminobutyraldehyde dehydrogenase (4-aminobutanal:NAD+ 1-oxidoreductase)

enzyme lambda metabolic reaction experiment
uniprot:P49189 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype fusion protein to maltose-binding protein]

H2O + 4_Aminobutanal + NAD+ -> NADH + 4_Aminobutanoate + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M sodium phosphate
PH: 7.4
Temperature: 37
uniprot:Q9JLJ3 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype]

H2O + NAD+ + 4_Aminobutanal -> 4_Aminobutanoate + NADH + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M sodium phosphate
PH: 7.4
Temperature: 37
uniprot:Q9JLJ3 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype fusion protein to maltose-binding protein]

NAD+ + 4_Aminobutanal + H2O -> H+ + 4_Aminobutanoate + NADH		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M sodium phosphate
PH: 7.4
Temperature: 37
uniprot:P77674 [aminobutyraldehyde dehydrogenase(Enzyme) mutant putrescine+]

NAD+ + 1_Pyrroline + 2 H2O -> 4_Aminobutanoate + NADH + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M citrate
PH: 5.4
Temperature: 30
uniprot:P77674 [aminobutyraldehyde dehydrogenase(Enzyme) mutant putrescine+]

2 H2O + NAD+ + 1_Pyrroline -> NADH + H+ + 4_Aminobutanoate		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M citrate
PH: 5.4
Temperature: 30
uniprot:P77674 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype YdcW]

NAD+ + 4_Aminobutanal + H2O -> H+ + 4_Aminobutanoate + NADH		 (( (( (kcat * E) ) * S2) ) / (Km2 + S2)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P77674 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype YdcW]

NAD+ + H2O + 4_Aminobutanal -> 4_Aminobutanoate + H+ + NADH		 (( (( (kcat * E) ) * S1) ) / (Km1 + S1)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P77674 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype YdcW]

H2O + 4_Aminobutanal + NADP+ -> NADPH + 4_Aminobutanoate + H+		 (( (( (kcat * E) ) * S2) ) / (Km2 + S2)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P77674 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype YdcW]

Butanal + H2O + NAD+ -> NADH + H+ + Butanoate		 (( (( (kcat * E) ) * S1) ) / (Km1 + S1)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P49189 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype E3' isoform]

H2O + 4_Aminobutanal + NAD+ -> NADH + H+ + 4_Aminobutanoate		 (( (Vmax * A) ) / (A + Km)) buffer: 100 mM Sodium phosphate, 1 mM EDTA
PH: 7.4
Temperature: 25
uniprot:P49189 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype E3' isoform]

H2O + NAD+ + 4_Aminobutanal -> NADH + 4_Aminobutanoate + H+		 (( (Vmax * A) ) / (A + Km)) buffer: 100 mM Sodium phosphate
PH: 8
Temperature: 37
uniprot:P49189 [aminobutyraldehyde dehydrogenase(Enzyme) wildtype His6-tag]

NAD+ + 4_Aminobutanal + H2O -> NADH + 4_Aminobutanoate + H+		 (( (Vmax * A) ) / (Km + A)) buffer: 150 mM sodium pyrophosphate
PH: 7.5
Temperature: 30

Pathways

pathway id name
BioCyc:HUMAN_PWY-6872 retinoate biosynthesis I
BioCyc:META_PWY-6872 retinoate biosynthesis I
BioCyc:META_PWY-6100 L-carnitine biosynthesis
BioCyc:ECO_ORNDEG-PWY superpathway of ornithine degradation
BioCyc:ECOO157_PWY0-1298 superpathway of pyrimidine deoxyribonucleosides degradation
BioCyc:ECOO157_P441-PWY superpathway of N-acetylneuraminate degradation
BioCyc:ECOO157_FUC-RHAMCAT-PWY superpathway of fucose and rhamnose degradation
BioCyc:ECOL316407_PUTDEG-PWY putrescine degradation I
BioCyc:HUMAN_PWY-6100 L-carnitine biosynthesis
BioCyc:META_ORNDEG-PWY superpathway of ornithine degradation
BioCyc:ECOO157_PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation
BioCyc:ECOO157_ETOH-ACETYLCOA-ANA-PWY ethanol degradation I
BioCyc:ECOO157_PWY0-1317 L-lactaldehyde degradation (aerobic)
BioCyc:ECOO157_FERMENTATION-PWY mixed acid fermentation
BioCyc:ECOO157_PWY-5162 2-oxopentenoate degradation
BioCyc:MOUSE_PWY-6100 L-carnitine biosynthesis
BioCyc:MOUSE_PWY-2501 fatty acid α-oxidation
BioCyc:ECOL316407_ARGDEG-PWY superpathway of arginine, putrescine, and 4-aminobutyrate degradation
BioCyc:ECOL316407_ORNARGDEG-PWY superpathway of arginine and ornithine degradation
BioCyc:META_PUTDEG-PWY putrescine degradation I
BioCyc:ECO_ARGDEG-PWY superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation
BioCyc:ECO_ORNARGDEG-PWY superpathway of L-arginine and L-ornithine degradation
BioCyc:ARA_PWY-2 putrescine degradation IV
BioCyc:ECOO157_PWY66-21 ethanol degradation II
BioCyc:ECOO157_PWY0-1297 superpathway of purine deoxyribonucleosides degradation
BioCyc:ECOO157_P461-PWY hexitol fermentation to lactate, formate, ethanol and acetate
BioCyc:ECOL199310_BETSYN-PWY glycine betaine biosynthesis I (Gram-negative bacteria)
BioCyc:ECOL316407_ORNDEG-PWY superpathway of ornithine degradation
BioCyc:META_PWY1F-353 glycine betaine biosynthesis III (plants)
BioCyc:META_PWY-2 putrescine degradation IV
BioCyc:META_ARGDEG-PWY superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation
BioCyc:META_ORNARGDEG-PWY superpathway of L-arginine and L-ornithine degradation
BioCyc:ECO_PUTDEG-PWY putrescine degradation I
BioCyc:ARA_PWY1F-353 glycine betaine biosynthesis III (plants)
BioCyc:ECOO157_DARABCATK12-PWY D-arabinose degradation I
BioCyc:ECOO157_PWY-5480 pyruvate fermentation to ethanol I
BioCyc:ECOO157_PWY0-1277 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation
BioCyc:MOUSE_PWY-0 putrescine degradation III
BioCyc:MOUSE_PWY-3981 β-alanine biosynthesis I
PathBank:SMP0000812 Arginine Metabolism
PathBank:SMP0000813 Ornithine Metabolism
PlantCyc:ARA_PWY1F-353 glycine betaine biosynthesis III (plants)
PlantCyc:PLANT_PWY1F-353 glycine betaine biosynthesis III (plants)
PlantCyc:PLANT_PWY-2 putrescine degradation IV
PlantCyc:ARA_PWY-2 putrescine degradation IV
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-211945 Phase I - Functionalization of compounds
Reactome:R-BTA-71384 Ethanol oxidation
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-5362517 Signaling by Retinoic Acid
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-RNO-70350 Fructose catabolism
Reactome:R-RNO-211945 Phase I - Functionalization of compounds
Reactome:R-RNO-71384 Ethanol oxidation
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-BTA-70350 Fructose catabolism
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-BTA-5365859 RA biosynthesis pathway
Reactome:R-HSA-71387 Carbohydrate metabolism
Reactome:R-HSA-70350 Fructose catabolism
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-70350 Fructose catabolism
Reactome:R-MMU-5365859 RA biosynthesis pathway
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-SSC-1430728 Metabolism
Reactome:R-BTA-71387 Carbohydrate metabolism
Reactome:R-BTA-5652084 Fructose metabolism
Reactome:R-BTA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-5652084 Fructose metabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-71262 Carnitine synthesis
Reactome:R-HSA-211945 Phase I - Functionalization of compounds
Reactome:R-HSA-71384 Ethanol oxidation
Reactome:R-HSA-5365859 RA biosynthesis pathway
Reactome:R-MMU-71387 Carbohydrate metabolism
Reactome:R-MMU-5652084 Fructose metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71262 Carnitine synthesis
Reactome:R-MMU-211945 Phase I - Functionalization of compounds
Reactome:R-MMU-71384 Ethanol oxidation
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-RNO-71262 Carnitine synthesis
Reactome:R-RNO-5362517 Signaling by Retinoic Acid
Reactome:R-SSC-71291 Amino acid and derivative metabolism
Reactome:R-SSC-71262 Carnitine synthesis
Reactome:R-BTA-5362517 Signaling by Retinoic Acid
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-MMU-5362517 Signaling by Retinoic Acid
Reactome:R-RNO-71387 Carbohydrate metabolism
Reactome:R-RNO-5652084 Fructose metabolism
Reactome:R-RNO-5365859 RA biosynthesis pathway
WikiPathways:WP5188 Retinol metabolism
WikiPathways:WP4159 GABA receptor signaling
PathBank:SMP0000447 Cyclophosphamide Action Pathway
PathBank:SMP0000605 Ifosfamide Metabolism Pathway
PathBank:SMP0012047 Glycine Betaine Biosynthesis I
PathBank:SMP0000604 Cyclophosphamide Metabolism Pathway
PathBank:SMP0000465 Carnitine Synthesis
PathBank:SMP0000074 Retinol Metabolism
PathBank:SMP0000336 Vitamin A Deficiency
PathBank:SMP0000448 Ifosfamide Action Pathway
PathBank:SMP0000642 Nevirapine Metabolism Pathway
PathBank:SMP0087187 Carnitine Synthesis
PathBank:SMP0012048 Glycine Betaine Biosynthesis II