4-Hydroperoxycyclophosphamide (BioCAD00000176292)

blood

Metabolite Card

Formula: C7H15Cl2N2O4P (292.0146)
SMILES: OOC1CCOP(=O)(N1)N(CCCl)CCCl

Synonyms [en]

2-(Bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine; 4-Hydroperoxycyclophosphamide; 4-Hydroperoxycyclofosfamide; perfosfamide; 2-(bis(2-chloroethyl)amino)tetrahydro-2-oxideo-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide; 4-OOH Cyclophosphamide

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

4-Hydroperoxycyclophosphamide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000176292). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

4-hydroperoxycyclophosphamide is a phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties. It has a role as an antineoplastic agent, an immunosuppressive agent, an alkylating agent, a metabolite and a drug allergen. It is a phosphorodiamide, a nitrogen mustard, a peroxol and an organochlorine compound. Perfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm. Perfosfamide is the active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 39800-16-3
  • CAS Registry Number: 62435-42-1
  • PubChem: 38347
  • PubChem: 9554809
  • PubChem: 9690122
  • ChEBI: ChEBI:135223
  • ChEBI: ChEBI:196991
  • HMDB: HMDB0246437
  • NCBI MeSH: perfosfamide
  • Wikipedia: Perfosfamide
  • DrugBank: DB12727

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-211945 Phase I - Functionalization of compounds
Reactome:R-CEL-211859 Biological oxidations
Reactome:R-DDI-211859 Biological oxidations
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-RNO-211945 Phase I - Functionalization of compounds
Reactome:R-SSC-211945 Phase I - Functionalization of compounds
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-DRE-211945 Phase I - Functionalization of compounds
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-211945 Phase I - Functionalization of compounds
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-211945 Phase I - Functionalization of compounds
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-211859 Biological oxidations
Reactome:R-XTR-211945 Phase I - Functionalization of compounds
Reactome:R-CEL-211945 Phase I - Functionalization of compounds
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