superpathway of chorismate metabolism
Keating TA, Marshall CG, Walsh CT. Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH. Biochemistry. 2000 Dec 19;39(50):15522–30. doi: 10.1021/bi0016523. PMID: 11112538.
Metabolites
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate
Formula: C32H58N2O7S (614.3964518)
CAS ID: 75621-03-3
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate
Formula: C14H13O9 (325.0559548)
CAS ID:
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.14.13.- | |||
| 1.1.1.25 | shikimate dehydrogenase (NADP+) | shikimate:NADP+ 3-oxidoreductase | |
| 1.1.1.282 | quinate/shikimate dehydrogenase [NAD(P)+] | L-quinate:NAD(P)+ 3-oxidoreductase | |
| 1.14.13.240 | 2-polyprenylphenol 6-hydroxylase | 2-(all-trans-polyprenyl)phenol,NADPH:oxygen oxidoreductase (6-hydroxylating) | |
| 1.14.99.60 | 3-demethoxyubiquinol 3-hydroxylase | 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol,acceptor:oxygen oxidoreductase (5-hydroxylating) | |
| 1.3.1.12 | prephenate dehydrogenase | prephenate:NAD+ oxidoreductase (decarboxylating) | |
| 1.3.1.28 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | (2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase | |
| 1.5.1.3 | dihydrofolate reductase | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase | |
| 1.5.1.50 | dihydromonapterin reductase | 5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase | |
| 2.1.1.163 | demethylmenaquinone methyltransferase | S-adenosyl-L-methione:demethylmenaquinone methyltransferase | |
| 2.1.1.201 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase | S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase | |
| 2.1.1.222 | 2-polyprenyl-6-hydroxyphenol methylase | S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase | |
| 2.1.1.64 | 3-demethylubiquinol 3-O-methyltransferase | S-adenosyl-L-methionine:3-hydroxy-2-methoxy-5-methyl-6-(all-trans-polyprenyl)-1,4-benzoquinol 3-O-methyltransferase | |
| 2.2.1.9 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase | isochorismate:2-oxoglutarate 4-oxopentanoatetransferase (decarboxylating) | |
| 2.4.2.18 | anthranilate phosphoribosyltransferase | N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase | |
| 2.5.1.10 | (2E,6E)-farnesyl diphosphate synthase | geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase | |
| 2.5.1.15 | dihydropteroate synthase | (7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase | |
| 2.5.1.19 | 3-phosphoshikimate 1-carboxyvinyltransferase | phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase | |
| 2.5.1.39 | 4-hydroxybenzoate polyprenyltransferase | polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase | |
| 2.5.1.54 | 3-deoxy-7-phosphoheptulonate synthase | phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) | |
| 2.5.1.74 | 1,4-dihydroxy-2-naphthoate polyprenyltransferase | all-trans-polyprenyl diphosphate:1,4-dihydroxy-2-naphthoate polyprenyltransferase | |
| 2.5.1.90 | all-trans-octaprenyl-diphosphate synthase | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units) | |
| 2.6.1.1 | aspartate transaminase | L-aspartate:2-oxoglutarate aminotransferase | |
| 2.6.1.107 | beta-methylphenylalanine transaminase | (2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase | |
| 2.6.1.42 | branched-chain-amino-acid transaminase | branched-chain-amino-acid:2-oxoglutarate aminotransferase | |
| 2.6.1.57 | aromatic-amino-acid transaminase | aromatic-amino-acid:2-oxoglutarate aminotransferase | |
| 2.6.1.85 | aminodeoxychorismate synthase | chorismate:L-glutamine aminotransferase | |
| 2.7.1.71 | shikimate kinase | ATP:shikimate 3-phosphotransferase | |
| 2.7.6.3 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase | |
| 3.1.2.28 | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase | |
| 3.3.2.1 | isochorismatase | isochorismate pyruvate-hydrolase | |
| 3.5.4.16 | GTP cyclohydrolase I | GTP 7,8-8,9-dihydrolase | |
| 3.6.1.67 | dihydroneopterin triphosphate diphosphatase | 7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase | |
| 4.1.1.48 | indole-3-glycerol-phosphate synthase | 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(indol-3-yl)glycerol-3-phosphate-forming] | |
| 4.1.1.98 | 4-hydroxy-3-polyprenylbenzoate decarboxylase | 4-hydroxy-3-polyprenylbenzoate carboxy-lyase | |
| 4.1.2.25 | dihydroneopterin aldolase | 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming] | |
| 4.1.3.27 | anthranilate synthase | chorismate pyruvate-lyase (amino-accepting; anthranilate-forming) | |
| 4.1.3.36 | 1,4-dihydroxy-2-naphthoyl-CoA synthase | 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing) | |
| 4.1.3.38 | aminodeoxychorismate lyase | 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) | |
| 4.1.3.40 | chorismate lyase | chorismate pyruvate-lyase (4-hydroxybenzoate-forming) | |
| 4.2.1.10 | 3-dehydroquinate dehydratase | 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming) | |
| 4.2.1.113 | o-succinylbenzoate synthase | (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate hydrolyase (2-succinylbenzoate-forming) | |
| 4.2.1.20 | tryptophan synthase | L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming] | |
| 4.2.1.51 | prephenate dehydratase | prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming) | |
| 4.2.3.4 | 3-dehydroquinate synthase | 3-deoxy-D-arabino-hept-2-ulosonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming) | |
| 4.2.3.5 | chorismate synthase | 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming) | |
| 4.2.99.20 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase | 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate pyruvate-lyase [(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate-forming] | |
| 5.1.99.8 | 7,8-dihydroneopterin epimerase | 7,8-dihydroneopterin 2'-epimerase | |
| 5.3.1.24 | phosphoribosylanthranilate isomerase | N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase | |
| 5.3.3.2 | isopentenyl-diphosphate DELTA-isomerase | 3-methylbut-3-en-1-yl-diphosphate DELTA3-DELTA2-isomerase | |
| 5.4.4.2 | isochorismate synthase | isochorismate hydroxymutase | |
| 5.4.99.5 | chorismate mutase | Chorismate pyruvatemutase | |
| 6.2.1.26 | O-succinylbenzoate-CoA ligase | 2-succinylbenzoate:CoA ligase (AMP-forming) | |
| 6.2.1.72 | L-serine-[L-seryl-carrier protein] ligase | L-serine:[L-seryl-carrier protein] ligase (AMP-forming) | |
| 6.3.2.12 | dihydrofolate synthase | 7,8-dihydropteroate:L-glutamate ligase (ADP-forming) | |
| 6.3.2.14 | enterobactin synthase | 2,3-dihydroxybenzoate:L-serine ligase | |
| 6.3.2.17 | tetrahydrofolate synthase | tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P00509 | aspC | Aspartate aminotransferase |
| P00887 | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive |
| P00888 | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive |
| P00895 | trpE | Anthranilate synthase component 1 |
| P00903 | pabA | Aminodeoxychorismate synthase component 2 |
| P00904 | trpGD | Bifunctional protein TrpGD |
| P00909 | trpC | Tryptophan biosynthesis protein TrpCF |
| P04693 | tyrB | Aromatic-amino-acid aminotransferase |
| P05041 | pabB | Aminodeoxychorismate synthase component 1 |
| P05194 | aroD | 3-dehydroquinate dehydratase |
| P07023 | tyrA | T-protein |
| P07639 | aroB | 3-dehydroquinate synthase |
| P08192 | folC | Dihydrofolate synthase/folylpolyglutamate synthase |
| P0A6D3 | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase |
| P0A6D5 | ydiB | Quinate/shikimate dehydrogenase |
| P0A6D7 | aroK | Shikimate kinase 1 |
| P0A6E1 | aroL | Shikimate kinase 2 |
| P0A6T5 | folE | GTP cyclohydrolase 1 |
| P0A877 | trpA | Tryptophan synthase alpha chain |
| P0A879 | trpB | Tryptophan synthase beta chain |
| P0A887 | ubiE | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE |
| P0A9J8 | pheA | Bifunctional chorismate mutase/prephenate dehydratase |
| P0AAB4 | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase |
| P0AB80 | ilvE | Branched-chain-amino-acid aminotransferase |
| P0AB91 | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive |
| P0ABQ4 | folA | Dihydrofolate reductase |
| P0ABU0 | menB | 1,4-dihydroxy-2-naphthoyl-CoA synthase |
| P0AC13 | folP | Dihydropteroate synthase |
| P0AC16 | folB | Dihydroneopterin aldolase |
| P0AD57 | ispB | Octaprenyl diphosphate synthase |
| P0ADI4 | entB | Enterobactin synthase component B |
| P0AEJ2 | entC | Isochorismate synthase EntC |
| P0AFC0 | nudB | Dihydroneopterin triphosphate diphosphatase |
| P0AFS3 | folM | Dihydromonapterin reductase |
| P0AGK1 | ubiA | 4-hydroxybenzoate octaprenyltransferase |
| P11454 | entF | Enterobactin synthase component F |
| P12008 | aroC | Chorismate synthase |
| P15047 | entA | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase |
| P15770 | aroE | Shikimate dehydrogenase (NADP(+)) |
| P17109 | menD | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase |
| P17993 | ubiG | Ubiquinone biosynthesis O-methyltransferase |
| P19925 | entD | Enterobactin synthase component D |
| P22939 | ispA | Farnesyl diphosphate synthase |
| P25534 | ubiH | 2-octaprenyl-6-methoxyphenol hydroxylase |
| P25535 | ubiI | 2-octaprenylphenol hydroxylase |
| P26281 | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
| P26602 | ubiC | Chorismate pyruvate-lyase |
| P28305 | pabC | Aminodeoxychorismate lyase |
| P29208 | menC | o-succinylbenzoate synthase |
| P32166 | menA | 1,4-dihydroxy-2-naphthoate octaprenyltransferase |
| P37353 | menE | 2-succinylbenzoate--CoA ligase |
| P37355 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase |
| P38051 | menF | Isochorismate synthase MenF |
| P75728 | ubiF | 3-demethoxyubiquinol 3-hydroxylase |
| P77781 | menI | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase |
| Q46822 | idi | Isopentenyl-diphosphate Delta-isomerase |