EC: 3.5.1.2

glutaminase (L-glutamine amidohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:P77454 [Ampicillin]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 7.5
Temperature: 37
uniprot:P77454 [Ampicillin]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 7.5
Temperature: 37
uniprot:O07637 [glutaminase(Enzyme) wildtype YlaM His6-tagged]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 7.5
Temperature: 37
uniprot:P77454 [glutaminase(Enzyme) mutant YbaS G261A His6-tagged]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 7.5
Temperature: 37
uniprot:P77454 [glutaminase(Enzyme) mutant YbaS Q162A His6-tagged]

H2O + L_Glutamine -> L_Glutamate + NH3		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 7.5
Temperature: 37
uniprot:O31465 [glutaminase(Enzyme) wildtype YbgJ His6-tagged]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 8
Temperature: 37
uniprot:P77454 [glutaminase(Enzyme) wildtype YbaS His6-tagged]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 7.5
Temperature: 37
uniprot:P0A6W0 [glutaminase(Enzyme) wildtype YneH His6-tagged]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM HEPES-K, 0.2 mM NADH, 1 mM EDTA, 0.2 mM alpha-ketoglutarate, 1 U/ml glutamate dehydrogenase
PH: 7.5
Temperature: 37
- [glutaminase(Enzyme) wildtype SNO1(His-tagged)-SNZ1 complex]

H2O + L_Glutamine -> L_Glutamate + NH3		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl
PH: 8
Temperature: 30
uniprot:Q8LPN3 [glutaminase(Enzyme) wildtype His-tagged]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 100 mM Tris/HCl, 5 mM MgCl2
PH: 8
Temperature: 37
uniprot:Q9CI75 [GTP]

H2O + L_Glutamine -> L_Glutamate + NH3		 (( (Vapp * S) ) / (Km + S)) buffer: 50 mM Hepes, 2 mM dithiothreitol
PH: 8
Temperature: 30
uniprot:Q9CI75 [GTP]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vapp * S) ) / (Km + S)) buffer: 50 mM Hepes, 2 mM dithiothreitol
PH: 8
Temperature: 30
uniprot:Q9CI75 [glutaminase(Enzyme) mutant R433M]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vapp * S) ) / (Km + S)) buffer: 50 mM Hepes, 2 mM dithiothreitol
PH: 8
Temperature: 30
uniprot:Q9CI75 [glutaminase(Enzyme) wildtype]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vapp * S) ) / (Km + S)) buffer: 50 mM Hepes, 2 mM dithiothreitol
PH: 8
Temperature: 30
uniprot:Q9CI75 [glutaminase(Enzyme) mutant T431V]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vapp * S) ) / (Km + S)) buffer: 50 mM Hepes, 2 mM dithiothreitol
PH: 8
Temperature: 30
uniprot:Q9CI75 [GTP]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vapp * S) ) / (Km + S)) buffer: 50 mM Hepes, 2 mM dithiothreitol
PH: 8
Temperature: 30
uniprot:Q9UI32 [Phosphate]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vmax * (A ^ n)) ) / (( (A_half ^ n) ) + (A ^ n))) buffer: 50 mM Hepes-Bicine
PH: 8
Temperature: 37
uniprot:P28492 [Phosphate]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (A ^ n)) ) / (( (A_half ^ n) ) + (A ^ n))) buffer: 50 mM Hepes-Bicine
PH: 8
Temperature: 37
uniprot:Q9UI32 [NH4+]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Potassium/Hepes/Bicine, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q9UI32 [glutaminase(Enzyme) wildtype liver isoform]

H2O + L_Glutamine -> L_Glutamate + NH3		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 100 mM Phosphate, 10 mM Hepes
PH: 8
Temperature: 37
uniprot:Q9UI32 [glutaminase(Enzyme) wildtype liver isoform]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Potassium/Hepes/Bicine, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q9UI32 [glutaminase(Enzyme) wildtype liver isoform]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Potassium/Hepes/Bicine, 10 mM Potassium phosphate
PH: 8.2
Temperature: 37
uniprot:P28492 [glutaminase(Enzyme) wildtype liver isoform]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 100 mM Phosphate, 10 mM Hepes
PH: 8
Temperature: 37
uniprot:P28492 [glutaminase(Enzyme) wildtype liver isoform]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 10 mM Phosphate, 50 mM Hepes
PH: 7.4
Temperature: 37
uniprot:Q9UI32 [glutaminase(Enzyme) wildtype liver isoform]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 10 mM Phosphate, 50 mM Hepes
PH: 7.4
Temperature: 37
uniprot:Q9UI32 [Hydrogencarbonate]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Potassium/Hepes/Bicine, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q9UI32 [Hydrogencarbonate]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Potassium/Hepes/Bicine, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:P28492 [Hydrogencarbonate]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Potassium/Hepes/Bicine, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:P28492 [NH4Cl]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 40 mM Potassium/Hepes, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:P28492 [KCl]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 40 mM Potassium/Hepes, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:Q9UI32 [NH4+]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Potassium/Hepes/Bicine, 10 mM Potassium phosphate
PH: 8.2
Temperature: 37
uniprot:P28492 [NH4Cl]

L_Glutamine + H2O -> L_Glutamate + NH3		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 40 mM Potassium/Hepes, 10 mM Potassium phosphate
PH: 7.4
Temperature: 37
uniprot:O94925 [glutaminase(Enzyme) wildtype kidney isoform]

H2O + L_Glutamine -> NH3 + L_Glutamate		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Phosphate
PH: 8.6
Temperature: 37
- [glutaminase(Enzyme) wildtype YaaE/YaaD]

L_Glutamine + H2O -> NH3 + L_Glutamate		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Tris-Cl, 0.5 mM APAD, 23 U/ml bovine glutamate dehydrogenase
PH: 8
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY-5686 UMP biosynthesis
BioCyc:META_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
BioCyc:YEAST_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
BioCyc:YEAST_CITRULBIO-PWY citrulline biosynthesis
BioCyc:ARA_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
BioCyc:ARA_CITRULBIO-PWY L-citrulline biosynthesis
BioCyc:ARA_HISTSYN-PWY L-histidine biosynthesis
BioCyc:MTBH37RV_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
BioCyc:MTBH37RV_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:MTBCDC1551_PWY-6543 4-aminobenzoate biosynthesis
BioCyc:MTBCDC1551_PWY-7221 guanosine ribonucleotides de novo biosynthesis
BioCyc:MTBCDC1551_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:MTBCDC1551_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:MTBCDC1551_HISTSYN-PWY L-histidine biosynthesis
BioCyc:MTBCDC1551_PWY-7228 superpathway of guanosine nucleotides de novo biosynthesis I
BioCyc:MTBCDC1551_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:ECOL199310_HISTSYN-PWY histidine biosynthesis
BioCyc:BSUB_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:ECOL316407_HISTSYN-PWY histidine biosynthesis
BioCyc:CORYNE_PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis
BioCyc:CORYNE_HISTSYN-PWY L-histidine biosynthesis
BioCyc:GCF_000013425_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:GCF_000013425_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:HUMAN_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
BioCyc:HUMAN_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis
BioCyc:META_PWY-5686 UMP biosynthesis I
BioCyc:META_HISTSYN-PWY L-histidine biosynthesis
BioCyc:ARA_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:MTBH37RV_PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis
BioCyc:MTBCDC1551_PWY-7054 N-acetylglutaminylglutamine amide biosynthesis
BioCyc:CAULO_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:ANTHRA_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:ANTHRA_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:ANTHRA_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:AGRO_PWY-6543 4-aminobenzoate biosynthesis
BioCyc:AGRO_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:MOUSE_PWY-5004 superpathway of citrulline metabolism
BioCyc:MOUSE_GLUTFUMARATE-PWY glutamine degradation II
BioCyc:MOUSE_GLUTAMINE-DEG1-PWY glutamine degradation I
BioCyc:SYNEL_PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis
BioCyc:SYNEL_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:PDIF272563_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:CORYNE_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:GCF_000013425_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
BioCyc:HUMAN_GLUTAMINDEG-PWY glutamine degradation/glutamate biosynthesis
BioCyc:META_PWY-7790 UMP biosynthesis II
BioCyc:META_CITRULBIO-PWY L-citrulline biosynthesis
BioCyc:META_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis
BioCyc:META_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
BioCyc:ECO_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:YEAST_HISTSYN-PWY histidine biosynthesis
BioCyc:YEAST_GLUTAMINDEG-PWY glutamine degradation I
BioCyc:YEAST_PWY-7790 UMP biosynthesis II
BioCyc:ECOO157_PWY-7221 guanosine ribonucleotides de novo biosynthesis
BioCyc:ECOO157_PWY-7228 superpathway of guanosine nucleotides de novo biosynthesis I
BioCyc:ECOL199310_GLUTAMINDEG-PWY glutamine degradation I
BioCyc:CAULO_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:CAULO_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:ANTHRA_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:ANTHRA_PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis
BioCyc:AGRO_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:BSUB_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:CAULONA1000_GLUTAMINDEG-PWY glutamine degradation I
BioCyc:CORYNE_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:META_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:ECO_HISTSYN-PWY L-histidine biosynthesis
BioCyc:YEAST_PYRIMID-RNTSYN-PWY de novo biosynthesis of pyrimidine ribonucleotides
BioCyc:MTBH37RV_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:MTBH37RV_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
BioCyc:MTBCDC1551_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:MTBCDC1551_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:MTBCDC1551_PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis
BioCyc:MTBCDC1551_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:CAULO_PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis
BioCyc:CAULO_GLUTAMINDEG-PWY glutamine degradation I
BioCyc:ANTHRA_DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II
BioCyc:AGRO_PWY-7221 guanosine ribonucleotides de novo biosynthesis
BioCyc:MOUSE_CITRULBIO-PWY citrulline biosynthesis
BioCyc:BSUB_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
BioCyc:BSUB_PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis
BioCyc:BSUB_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:BSUB_GLUTAMINDEG-PWY L-glutamine degradation I
BioCyc:SYNEL_HISTSYN-PWY L-histidine biosynthesis
BioCyc:SYNEL_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:SYNEL_PWY-841 superpathway of purine nucleotides de novo biosynthesis I
BioCyc:SYNEL_DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II
BioCyc:ECOL316407_GLUTAMINDEG-PWY glutamine degradation I
BioCyc:BTHE_GLUTAMINDEG-PWY glutamine degradation I
BioCyc:BTHE_HISTSYN-PWY histidine biosynthesis
BioCyc:CORYNE_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
PathBank:SMP0000792 D-Glutamine and D-Glutamate Metabolism
PathBank:SMP0000811 L-Glutamate Metabolism
PathBank:SMP0000830 Histidine Biosynthesis
PathBank:SMP0001000 Secondary Metabolites: Histidine Biosynthesis
PlantCyc:ARA_PWY490-4 L-asparagine biosynthesis III (tRNA-dependent)
PlantCyc:ARA_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
PlantCyc:ARA_GLUTAMINDEG-PWY L-glutamine degradation I
PlantCyc:PLANT_PWY-5921 glutaminyl-tRNAgln biosynthesis via transamidation
PlantCyc:ARA_CITRULBIO-PWY L-citrulline biosynthesis
PlantCyc:ARA_PWY-5004 superpathway of L-citrulline metabolism
PlantCyc:PLANT_PWY-5004 superpathway of L-citrulline metabolism
PlantCyc:PLANT_PWY490-4 L-asparagine biosynthesis III (tRNA-dependent)
PlantCyc:PLANT_PWY-6466 pyridoxal 5'-phosphate biosynthesis II
PlantCyc:ARA_HISTSYN-PWY L-histidine biosynthesis
PlantCyc:ARA_PWY-5921 glutaminyl-tRNAgln biosynthesis via transamidation
PlantCyc:PLANT_HISTSYN-PWY L-histidine biosynthesis
PlantCyc:PLANT_CITRULBIO-PWY L-citrulline biosynthesis
Reactome:R-RNO-8964539 Glutamate and glutamine metabolism
Reactome:R-MMU-8964539 Glutamate and glutamine metabolism
Reactome:R-HSA-8964539 Glutamate and glutamine metabolism
Reactome:R-CEL-500753 Pyrimidine biosynthesis
Reactome:R-DDI-8956320 Nucleotide biosynthesis
Reactome:R-DME-500753 Pyrimidine biosynthesis
Reactome:R-HSA-112315 Transmission across Chemical Synapses
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-3700989 Transcriptional Regulation by TP53
Reactome:R-RNO-112316 Neuronal System
Reactome:R-RNO-210500 Glutamate Neurotransmitter Release Cycle
Reactome:R-SCE-500753 Pyrimidine biosynthesis
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-15869 Nucleotide metabolism
Reactome:R-DDI-15869 Nucleotide metabolism
Reactome:R-DME-1430728 Metabolism
Reactome:R-HSA-8956320 Nucleotide biosynthesis
Reactome:R-MMU-8956320 Nucleotide biosynthesis
Reactome:R-MMU-112310 Neurotransmitter release cycle
Reactome:R-RNO-112315 Transmission across Chemical Synapses
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SPO-500753 Pyrimidine biosynthesis
Reactome:R-CEL-15869 Nucleotide metabolism
Reactome:R-DME-15869 Nucleotide metabolism
Reactome:R-HSA-500753 Pyrimidine biosynthesis
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-112316 Neuronal System
Reactome:R-HSA-210500 Glutamate Neurotransmitter Release Cycle
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-3700989 Transcriptional Regulation by TP53
Reactome:R-MMU-500753 Pyrimidine biosynthesis
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-5628897 TP53 Regulates Metabolic Genes
Reactome:R-MMU-112315 Transmission across Chemical Synapses
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-RNO-112310 Neurotransmitter release cycle
Reactome:R-RNO-74160 Gene expression (Transcription)
Reactome:R-RNO-73857 RNA Polymerase II Transcription
Reactome:R-RNO-3700989 Transcriptional Regulation by TP53
Reactome:R-SCE-15869 Nucleotide metabolism
Reactome:R-SPO-8956320 Nucleotide biosynthesis
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-8956320 Nucleotide biosynthesis
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-500753 Pyrimidine biosynthesis
Reactome:R-DME-8956320 Nucleotide biosynthesis
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-15869 Nucleotide metabolism
Reactome:R-HSA-112310 Neurotransmitter release cycle
Reactome:R-HSA-5628897 TP53 Regulates Metabolic Genes
Reactome:R-MMU-15869 Nucleotide metabolism
Reactome:R-MMU-112316 Neuronal System
Reactome:R-MMU-210500 Glutamate Neurotransmitter Release Cycle
Reactome:R-RNO-212436 Generic Transcription Pathway
Reactome:R-RNO-5628897 TP53 Regulates Metabolic Genes
Reactome:R-SCE-8956320 Nucleotide biosynthesis
WikiPathways:WP4595 Urea cycle and associated pathways
WikiPathways:WP4225 Pyrimidine metabolism and related diseases
WikiPathways:WP4583 Biomarkers for urea cycle disorders
WikiPathways:WP4157 GABA metabolism (aka GHB)
WikiPathways:WP5220 Metabolic reprogramming in pancreatic cancer
WikiPathways:WP5312 Metabolic pathways of fibroblasts
PathBank:SMP0120666 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120682 Carbamoyl Phosphate Synthetase Deficiency
PathBank:SMP0120686 Citrullinemia Type I
PathBank:SMP0120714 Homocarnosinosis
PathBank:SMP0120762 Ornithine Transcarbamylase Deficiency (OTC Deficiency)
PathBank:SMP0120850 Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0108157 Apoptotic DNA Fragmentation and Tissue Homeostasis
PathBank:SMP0120456 Argininosuccinic Aciduria
PathBank:SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
PathBank:SMP0120496 Hyperinsulinism-Hyperammonemia Syndrome
PathBank:SMP0120504 Lactic Acidemia
PathBank:SMP0120569 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency
PathBank:SMP0120613 2-Ketoglutarate Dehydrogenase Complex Deficiency
PathBank:SMP0120637 Glycogenosis, Type IB
PathBank:SMP0120645 Glycogenosis, Type IA. Von Gierke Disease
PathBank:SMP0000059 Urea Cycle
PathBank:SMP0000009 Ammonia Recycling
PathBank:SMP0000339 Hyperinsulinism-Hyperammonemia Syndrome
PathBank:SMP0000001 Citrullinemia Type I
PathBank:SMP0000178 Dihydropyrimidinase Deficiency
PathBank:SMP0002358 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0002429 Histidine Metabolism
PathBank:SMP0087278 Glutamate Metabolism
PathBank:SMP0087282 Ammonia Recycling
PathBank:SMP0087426 Aspartate Metabolism
PathBank:SMP0063579 Ammonia Recycling
PathBank:SMP0063596 Arginine and Proline Metabolism
PathBank:SMP0063661 Pyruvate Metabolism
PathBank:SMP0120677 Argininosuccinic Aciduria
PathBank:SMP0108760 Glutaminolysis and Cancer
PathBank:SMP0108771 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0120455 Argininemia
PathBank:SMP0120499 Hyperprolinemia Type I
PathBank:SMP0120507 UMP Synthase Deficiency (Orotic Aciduria)
PathBank:SMP0120531 Pyruvate Dehydrogenase Complex Deficiency
PathBank:SMP0120535 Pyruvate Carboxylase Deficiency
PathBank:SMP0120539 Prolinemia Type II
PathBank:SMP0120543 Primary Hyperoxaluria Type I
PathBank:SMP0120572 L-Arginine:Glycine Amidinotransferase Deficiency
PathBank:SMP0120612 Mitochondrial Complex II Deficiency
PathBank:SMP0120624 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1)
PathBank:SMP0000046 Pyrimidine Metabolism
PathBank:SMP0000385 Homocarnosinosis
PathBank:SMP0000003 Argininosuccinic Aciduria
PathBank:SMP0000219 UMP Synthase Deficiency (Orotic Aciduria)
PathBank:SMP0000136 2-Hydroxyglutric Aciduria (D and L Form)
PathBank:SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0087473 Pyrimidine Metabolism
PathBank:SMP0063617 Gluconeogenesis
PathBank:SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis
PathBank:SMP0120676 Argininemia
PathBank:SMP0120716 Hyperinsulinism-Hyperammonemia Syndrome
PathBank:SMP0108758 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0108773 Glutaminolysis and Cancer
PathBank:SMP0120445 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120461 Canavan Disease
PathBank:SMP0120473 Dihydropyrimidinase Deficiency
PathBank:SMP0120501 Hyperprolinemia Type II
PathBank:SMP0120533 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0120541 Prolidase Deficiency (PD)
PathBank:SMP0120570 Hyperornithinemia with Gyrate Atrophy (HOGA)
PathBank:SMP0120610 Congenital Lactic Acidosis
PathBank:SMP0120614 Pyruvate Dehydrogenase Deficiency (E3)
PathBank:SMP0120622 Primary Hyperoxaluria II, PH2
PathBank:SMP0120626 Fructose-1,6-diphosphatase Deficiency
PathBank:SMP0120638 Glycogenosis, Type IC
PathBank:SMP0000067 Aspartate Metabolism
PathBank:SMP0000175 Canavan Disease
PathBank:SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency)
PathBank:SMP0000202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
PathBank:SMP0000654 Warburg Effect
PathBank:SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0002370 Pyrimidine Metabolism
PathBank:SMP0002426 Glutamine Metabolism
PathBank:SMP0087428 Glutamate Metabolism
PathBank:SMP0063586 Alanine Metabolism
PathBank:SMP0063590 Glutamate Metabolism
PathBank:SMP0063658 Pyrimidine Metabolism
PathBank:SMP0120659 2-Hydroxyglutric Aciduria (D and L Form)
PathBank:SMP0120438 2-Hydroxyglutric Aciduria (D and L Form)
PathBank:SMP0120454 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
PathBank:SMP0120458 beta-Ureidopropionase Deficiency
PathBank:SMP0120462 Carbamoyl Phosphate Synthetase Deficiency
PathBank:SMP0120466 Citrullinemia Type I
PathBank:SMP0120490 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
PathBank:SMP0120494 Homocarnosinosis
PathBank:SMP0120502 Hypoacetylaspartia
PathBank:SMP0120506 Leigh Syndrome
PathBank:SMP0120530 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
PathBank:SMP0120538 Ornithine Aminotransferase Deficiency (OAT Deficiency)
PathBank:SMP0120542 Ornithine Transcarbamylase Deficiency (OTC Deficiency)
PathBank:SMP0120571 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]
PathBank:SMP0120611 Fumarase Deficiency
PathBank:SMP0120615 Pyruvate Dehydrogenase Deficiency (E2)
PathBank:SMP0120623 Pyruvate Kinase Deficiency
PathBank:SMP0120627 Triosephosphate Isomerase Deficiency
PathBank:SMP0120631 Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000072 Glutamate Metabolism
PathBank:SMP0000243 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0000192 Hypoacetylaspartia
PathBank:SMP0000357 Argininemia
PathBank:SMP0000172 beta-Ureidopropionase Deficiency
PathBank:SMP0000002 Carbamoyl Phosphate Synthetase Deficiency
PathBank:SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0002298 Glutaminolysis and Cancer
PathBank:SMP0002335 Histidine Biosynthesis
PathBank:SMP0086930 Warburg Effect
PathBank:SMP0087319 Urea Cycle
PathBank:SMP0087363 Warburg Effect
PathBank:SMP0087431 Ammonia Recycling
PathBank:SMP0087527 Warburg Effect
PathBank:SMP0063477 Citric Acid Cycle
PathBank:SMP0063597 Aspartate Metabolism
PathBank:SMP0063681 Transfer of Acetyl Groups into Mitochondria
PathBank:SMP0063686 Urea Cycle