de novo biosynthesis of pyrimidine ribonucleotides

Wagner R, de Montigny J, de Wergifosse P, Souciet JL, Potier S. The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease. FEMS Microbiol Lett. 1998 Feb 01;159(1):69–75. doi: 10.1111/j.1574-6968.1998.tb12843.x. PMID: 9485596.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.3.98.1 dihydroorotate dehydrogenase (fumarate) (S)-dihydroorotate:fumarate oxidoreductase
2.1.3.2 aspartate carbamoyltransferase carbamoyl-phosphate:L-aspartate carbamoyltransferase
2.4.2.10 orotate phosphoribosyltransferase orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase
2.7.4.14 UMP/CMP kinase ATP:CMP(UMP) phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
3.5.1.2 glutaminase L-glutamine amidohydrolase
3.5.2.3 dihydroorotase (S)-dihydroorotate amidohydrolase
4.1.1.23 orotidine-5'-phosphate decarboxylase orotidine-5'-phosphate carboxy-lyase (UMP-forming)
6.3.4.16 carbamoyl-phosphate synthase (ammonia) carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
6.3.4.2 CTP synthase (glutamine hydrolysing) UTP:ammonia ligase (ADP-forming)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing) hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)


Proteins

Protein ID name full name
P03962 URA3 Orotidine 5'-phosphate decarboxylase
P07259 URA2 Multifunctional protein URA2
P13298 URA5 Orotate phosphoribosyltransferase 1
P15700 URA6 Uridylate kinase
P20051 URA4 Dihydroorotase
P28272 URA1 Dihydroorotate dehydrogenase (fumarate)
P28274 URA7 CTP synthase 1
P30402 URA10 Orotate phosphoribosyltransferase 2
P36010 YNK1 Nucleoside diphosphate kinase
P38627 URA8 CTP synthase 2