Histidine Biosynthesis

Metabolites

1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide

Formula: C9H15N4O8P (338.062748)

CAS ID: 3031-94-5

2-Oxoglutarate

Formula: C5H6O5 (146.0215226)

CAS ID: 328-50-7

3-(Imidazol-4-yl)-2-oxopropyl phosphate

Formula: C6H9N2O5P (220.0249074)

CAS ID: 99979-59-6

5-Amino-4-imidazolecarboxyamide

Formula: C4H6N4O (126.05415860000001)

CAS ID: 360-97-4

5-Phospho-alpha-D-ribose 1-diphosphate

Formula: C5H13O14P3 (389.9518188)

CAS ID: 7540-64-9

D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate

Formula: C6H11N2O6P (238.0354716)

CAS ID: 36244-87-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

L-Histidine

Formula: C6H9N3O2 (155.06947340000002)

CAS ID: 71-00-1

L-Histidinol

Formula: C6H11N3O (141.09020759999999)

CAS ID: 4836-52-6

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.1.1.23 histidinol dehydrogenase L-histidinol:NAD+ oxidoreductase
2.4.2.17 ATP phosphoribosyltransferase 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase
2.6.1.9 histidinol-phosphate transaminase L-histidinol-phosphate:2-oxoglutarate aminotransferase
3.1.3.15 histidinol-phosphatase L-histidinol-phosphate phosphohydrolase
3.5.1.2 glutaminase L-glutamine amidohydrolase
3.5.4.19 phosphoribosyl-AMP cyclohydrolase 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase
3.6.1.31 phosphoribosyl-ATP diphosphatase 1-(5-phosphoribosyl)-ATP diphosphohydrolase
4.2.1.19 imidazoleglycerol-phosphate dehydratase D-erythro-1-(imidazol-4-yl)glycerol-3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]
4.3.2.10 imidazole glycerol-phosphate synthase 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate-lyase (L-glutamine-hydrolysing; 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide-forming)
5.3.1.16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase


Proteins

Protein ID name full name
P06986 hisC Histidinol-phosphate aminotransferase
P06987 hisB Histidine biosynthesis bifunctional protein HisB
P06988 hisD Histidinol dehydrogenase
P06989 hisI Histidine biosynthesis bifunctional protein HisIE
P10371 hisA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
P60595 hisH Imidazole glycerol phosphate synthase subunit HisH
P60664 hisF Imidazole glycerol phosphate synthase subunit HisF
P60757 hisG ATP phosphoribosyltransferase