pyridoxal 5'-phosphate biosynthesis II

Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y, Zhou CZ. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010 Dec 15;432(3):445–50. doi: 10.1042/bj20101241. PMID: 20919991.; Neuwirth M, Strohmeier M, Windeisen V, Wallner S, Deller S, Rippe K, Sinning I, Macheroux P, Tews I. X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases. FEBS Letters. 2009 Jun 11;583(13):2179–86. doi: 10.1016/j.febslet.2009.06.009.; Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB: Vitamin B6 biosynthesis in higher plants. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13687-92. doi: 10.1073/pnas.0506228102. Epub 2005 Sep 12.; Burns KE, Xiang Y, Kinsland CL, McLafferty FW, Begley TP. Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway. J Am Chem Soc. 2005 Mar 23;127(11):3682–3. doi: 10.1021/ja042792t. PMID: 15771487.; Dong Y, Sueda S, Nikawa J, Kondo H. Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. European Journal of Biochemistry. 2004 Jan 26;271(4):745–52. doi: 10.1111/j.1432-1033.2003.03973.x.; Stolz J, Vielreicher M. Tpn1p, the Plasma Membrane Vitamin B6 Transporter of Saccharomyces cerevisiae. Journal of Biological Chemistry. 2003 May;278(21):18990–6. doi: 10.1074/jbc.m300949200.; Rodríguez-Navarro S, Llorente B, Rodríguez-Manzaneque MT, Ramne A, Uber G, Marchesan D, Dujon B, Herrero E, Sunnerhagen P, Pérez-Ortín JE. Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Yeast. 2002 Sep 23;19(14):1261–76. doi: 10.1002/yea.916.; Padilla PA, Fuge EK, Crawford ME, Errett A, Werner-Washburne M. The Highly Conserved, Coregulated SNO and SNZ Gene Families in Saccharomyces cerevisiae Respond to Nutrient Limitation. J Bacteriol. 1998 Nov;180(21):5718–26. doi: 10.1128/jb.180.21.5718-5726.1998.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5



Enzyme

EC Number name full name note
3.5.1.2 glutaminase L-glutamine amidohydrolase
4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5'-phosphate-lyase


Proteins

Protein ID name full name
P37527 pdxS Pyridoxal 5'-phosphate synthase subunit PdxS
P37528 pdxT Pyridoxal 5'-phosphate synthase subunit PdxT
Q03144 SNO1 Pyridoxal 5'-phosphate synthase subunit SNO1
Q03148 SNZ1 Pyridoxal 5'-phosphate synthase subunit SNZ1