L-histidine biosynthesis
Metabolites
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
Formula: C9H13N4O8P (336.0470988)
CAS ID:
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.23 | histidinol dehydrogenase | L-histidinol:NAD+ oxidoreductase | |
| 2.4.2.17 | ATP phosphoribosyltransferase | 1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase | |
| 2.6.1.9 | histidinol-phosphate transaminase | L-histidinol-phosphate:2-oxoglutarate aminotransferase | |
| 3.1.3.15 | histidinol-phosphatase | L-histidinol-phosphate phosphohydrolase | |
| 3.5.1.2 | glutaminase | L-glutamine amidohydrolase | |
| 3.5.4.19 | phosphoribosyl-AMP cyclohydrolase | 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase | |
| 3.6.1.31 | phosphoribosyl-ATP diphosphatase | 1-(5-phosphoribosyl)-ATP diphosphohydrolase | |
| 4.2.1.19 | imidazoleglycerol-phosphate dehydratase | D-erythro-1-(imidazol-4-yl)glycerol-3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming] | |
| 4.3.2.10 | imidazole glycerol-phosphate synthase | 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate-lyase (L-glutamine-hydrolysing; 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide-forming) | |
| 5.3.1.16 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P06986 | hisC | Histidinol-phosphate aminotransferase |
| P06987 | hisB | Histidine biosynthesis bifunctional protein HisB |
| P06988 | hisD | Histidinol dehydrogenase |
| P06989 | hisI | Histidine biosynthesis bifunctional protein HisIE |
| P10371 | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase |
| P60595 | hisH | Imidazole glycerol phosphate synthase subunit HisH |
| P60664 | hisF | Imidazole glycerol phosphate synthase subunit HisF |
| P60757 | hisG | ATP phosphoribosyltransferase |