Nucleotide biosynthesis

Zalkin H, Dixon JE. De novo purine nucleotide biosynthesis. Prog Nucleic Acid Res Mol Biol. 1992;42():259–87. doi: 10.1016/s0079-6603(08)60578-4. PMID: 1574589.; Jones ME. Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annu Rev Biochem. 1980;49():253–79. doi: 10.1146/annurev.bi.49.070180.001345. PMID: 6105839.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Ubiquinone-10

Formula: C59H90O4 (862.683874)

CAS ID: 303-98-0

QH(2)

Formula: C14H20O4 (252.136152)

CAS ID: 52590-98-4

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

Formula: C9H13N4O8P (336.0470988)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

beta-D-fructofuranose 1,6-bisphosphate(4-)

Formula: C6H10O12P2 (335.96475200000003)

CAS ID: 488-69-7



Enzyme

EC Number name full name note
1.1.1.205 IMP dehydrogenase IMP:NAD+ oxidoreductase
1.3.5.2 dihydroorotate dehydrogenase (quinone) (S)-dihydroorotate:quinone oxidoreductase
2.1.2.2 phosphoribosylglycinamide formyltransferase 1 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase
2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase
2.1.3.2 aspartate carbamoyltransferase carbamoyl-phosphate:L-aspartate carbamoyltransferase
2.4.2.10 orotate phosphoribosyltransferase orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase
2.4.2.14 amidophosphoribosyltransferase 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
3.5.1.2 glutaminase L-glutamine amidohydrolase
3.5.2.3 dihydroorotase (S)-dihydroorotate amidohydrolase
3.5.4.10 IMP cyclohydrolase IMP 1,2-hydrolase (decyclizing)
4.1.1.21 phosphoribosylaminoimidazole carboxylase 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
4.1.1.23 orotidine-5'-phosphate decarboxylase orotidine-5'-phosphate carboxy-lyase (UMP-forming)
4.3.2.2 adenylosuccinate lyase N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
6.3.4.13 phosphoribosylamine-glycine ligase 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
6.3.4.16 carbamoyl-phosphate synthase (ammonia) carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
6.3.5.2 GMP synthase (glutamine-hydrolysing) xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
6.3.5.3 phosphoribosylformylglycinamidine synthase N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing) hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)


Proteins

Protein ID name full name