Nucleotide metabolism
Welin M, Nordlund P. Understanding specificity in metabolic pathways—Structural biology of human nucleotide metabolism. Biochemical and Biophysical Research Communications. 2010 May;396(1):157–63. doi: 10.1016/j.bbrc.2010.04.054.; Hyde JE. Targeting purine and pyrimidine metabolism in human apicomplexan parasites. Curr Drug Targets. 2007 Jan;8(1):31–47. PMID: 17266529; PMCID: PMC2720675.; Rudolph FB. The biochemistry and physiology of nucleotides. J Nutr. 1994 Jan;124(1 Suppl):124S–127S. doi: 10.1093/jn/124.suppl_1.124s. PMID: 8283301.
Metabolites
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
Formula: C9H13N4O8P (336.0470988)
CAS ID:
beta-D-fructofuranose 1,6-bisphosphate(4-)
Formula: C6H10O12P2 (335.96475200000003)
CAS ID: 488-69-7
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.8.1.7 | glutathione-disulfide reductase | glutathione:NADP+ oxidoreductase | |
| 2.1.1.45 | thymidylate synthase | 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase | |
| 2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase | 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase | |
| 2.1.3.2 | aspartate carbamoyltransferase | carbamoyl-phosphate:L-aspartate carbamoyltransferase | |
| 2.4.2.1 | purine-nucleoside phosphorylase | purine-nucleoside:phosphate ribosyltransferase | |
| 2.4.2.7 | adenine phosphoribosyltransferase | AMP:diphosphate phospho-D-ribosyltransferase | |
| 2.7.1.20 | adenosine kinase | ATP:adenosine 5'-phosphotransferase | |
| 2.7.1.48 | uridine/cytidine kinase | ATP:uridine/cytidine 5'-phosphotransferase | |
| 2.7.4.10 | nucleoside-triphosphate-adenylate kinase | nucleoside-triphosphate:AMP phosphotransferase | |
| 2.7.4.14 | UMP/CMP kinase | ATP:CMP(UMP) phosphotransferase | |
| 2.7.4.3 | adenylate kinase | ATP:AMP phosphotransferase | |
| 2.7.4.6 | nucleoside-diphosphate kinase | ATP:nucleoside-diphosphate phosphotransferase | |
| 2.7.4.8 | guanylate kinase | ATP:(d)GMP phosphotransferase | |
| 3.1.3.96 | pseudouridine 5'-phosphatase | pseudouridine 5'-phosphohydrolase | |
| 3.5.1.2 | glutaminase | L-glutamine amidohydrolase | |
| 3.5.4.10 | IMP cyclohydrolase | IMP 1,2-hydrolase (decyclizing) | |
| 3.5.4.12 | dCMP deaminase | dCMP aminohydrolase | |
| 3.5.4.3 | guanine deaminase | guanine aminohydrolase | |
| 3.5.4.5 | cytidine deaminase | cytidine/2'-deoxycytidine aminohydrolase | |
| 3.5.4.6 | AMP deaminase | AMP aminohydrolase | |
| 3.6.1.13 | ADP-ribose diphosphatase | ADP-D-ribose ribophosphohydrolase | |
| 3.6.1.23 | dUTP diphosphatase | dUTP nucleotidohydrolase | |
| 3.6.1.42 | guanosine-diphosphatase | GDP phosphohydrolase | |
| 3.6.1.5 | apyrase | nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming) | |
| 3.6.1.66 | XTP/dITP diphosphatase | XTP/dITP diphosphohydrolase (diphosphate-forming) | |
| 4.3.2.2 | adenylosuccinate lyase | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) | |
| 6.3.3.1 | phosphoribosylformylglycinamidine cyclo-ligase | 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) | |
| 6.3.4.13 | phosphoribosylamine-glycine ligase | 5-phospho-D-ribosylamine:glycine ligase (ADP-forming) | |
| 6.3.4.16 | carbamoyl-phosphate synthase (ammonia) | carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating) | |
| 6.3.4.2 | CTP synthase (glutamine hydrolysing) | UTP:ammonia ligase (ADP-forming) | |
| 6.3.5.2 | GMP synthase (glutamine-hydrolysing) | xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming) | |
| 6.3.5.3 | phosphoribosylformylglycinamidine synthase | N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming) | |
| 6.3.5.5 | carbamoyl-phosphate synthase (glutamine-hydrolysing) | hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P06773 | DCD1 | Deoxycytidylate deaminase |
| P06785 | CDC21 | Thymidylate synthase |
| P07170 | ADK1 | Adenylate kinase |
| P07244 | ADE57 | Bifunctional purine biosynthetic protein ADE5,7 |
| P07259 | URA2 | Multifunctional protein URA2 |
| P15274 | AMD1 | AMP deaminase |
| P15454 | GUK1 | Guanylate kinase |
| P15700 | URA6 | Uridylate kinase |
| P26364 | ADK2 | GTP:AMP phosphotransferase, mitochondrial |
| P27515 | URK1 | Uridine kinase |
| P28274 | URA7 | CTP synthase 1 |
| P32621 | GDA1 | Guanosine-diphosphatase |
| P33317 | DUT1 | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
| P36010 | YNK1 | Nucleoside diphosphate kinase |
| P38009 | ADE17 | Bifunctional purine biosynthesis protein ADE17 |
| P38625 | GUA1 | GMP synthase [glutamine-hydrolyzing] |
| P38972 | ADE6 | Phosphoribosylformylglycinamidine synthase |
| P40009 | YND1 | Golgi apyrase |
| P41921 | GLR1 | Glutathione reductase |
| P47119 | HAM1 | Inosine triphosphate pyrophosphatase |
| P47143 | ADO1 | Adenosine kinase |
| P49435 | APT1 | Adenine phosphoribosyltransferase 1 |
| Q01976 | YSA1 | ADP-ribose pyrophosphatase |
| Q05788 | PNP1 | Purine nucleoside phosphorylase |
| Q05911 | ADE13 | Adenylosuccinate lyase |
| Q06549 | CDD1 | Cytidine deaminase |
| Q07729 | GUD1 | Probable guanine deaminase |
| Q12055 | FAP7 | Adenylate kinase isoenzyme 6 homolog FAP7 |
| Q86ZR7 | YKD3A_YEAST | Probable pseudouridine-5'-phosphatase YKL033W-A |