Metabolic pathways of fibroblasts

Rabinowitz JD, Mutlu GM. A metabolic strategy to reverse fibrosis? Nat Metab. 2019 Jan;1(1):12–3. doi: 10.1038/s42255-018-0013-8. PMID: 32694811.

Metabolites

(S)-Lactate

Formula: C3H6O3 (90.0316926)

CAS ID: 79-33-4

2-Oxoglutarate

Formula: C5H6O5 (146.0215226)

CAS ID: 328-50-7

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

beta-D-Glucose

Formula: C6H12O6 (180.0633852)

CAS ID: 492-61-5

D-Fructose 6-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 643-13-0

D-Glucose 1-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 59-56-3

D-Glucose 6-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 56-73-5

Glycerate 3-phosphate

Formula: C3H7O7P (185.9929402)

CAS ID: 820-11-1

Glycine

Formula: C2H5NO2 (75.032027)

CAS ID: 56-40-6

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

L-Proline

Formula: C5H9NO2 (115.0633254)

CAS ID: 147-85-3

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3

Serine

Formula: C3H7NO3 (105.0425912)

CAS ID: 302-84-1

UDP-glucuronate

Formula: C15H22N2O18P2 (580.0342852)

CAS ID: 2616-64-0

Heparan sulfate

Formula: C14H25NO21S3 (639.00812)

CAS ID: 9050-30-0



Enzyme

EC Number name full name note
1.1.1.22 UDP-glucose 6-dehydrogenase UDP-alpha-D-glucose:NAD+ 6-oxidoreductase
1.1.1.37 malate dehydrogenase (S)-malate:NAD+ oxidoreductase
1.1.1.399 2-oxoglutarate reductase (R)-2-hydroxyglutarate,NAD+ 2-oxidireductase
1.1.1.95 phosphoglycerate dehydrogenase 3-phospho-D-glycerate:NAD+ 2-oxidoreductase
1.2.1.41 glutamate-5-semialdehyde dehydrogenase L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
1.4.1.3 glutamate dehydrogenase [NAD(P)+] L-glutamate:NAD(P)+ oxidoreductase (deaminating)
1.5.1.2 pyrroline-5-carboxylate reductase L-proline:NAD(P)+ 5-oxidoreductase
2.1.2.1 glycine hydroxymethyltransferase 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
2.6.1.52 phosphoserine transaminase O-phospho-L-serine:2-oxoglutarate aminotransferase
2.7.1.1 hexokinase ATP:D-hexose 6-phosphotransferase
2.7.2.11 glutamate 5-kinase ATP:L-glutamate 5-phosphotransferase
2.7.7.9 UTP-glucose-1-phosphate uridylyltransferase UTP:alpha-D-glucose-1-phosphate uridylyltransferase
3.1.3.3 phosphoserine phosphatase O-phosphoserine phosphohydrolase
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
3.4.24.19 procollagen C-endopeptidase
3.5.1.2 glutaminase L-glutamine amidohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) alpha-D-glucose 1,6-phosphomutase


Proteins

Protein ID name full name
O62585 SHMT-1 Serine hydroxymethyltransferase, cytosolic