superpathway of pyrimidine ribonucleotides de novo biosynthesis

Zrenner R, Stitt M, Sonnewald U, Boldt R. Pyrimidine and purine biosynthesis and degradation in plants. Annu Rev Plant Biol. 2006;57():805–36. doi: 10.1146/annurev.arplant.57.032905.105421. PMID: 16669783.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Etoposide glucuronide

Formula: C35H40O19 (764.216369)

CAS ID: 100007-55-4

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

cyanate

Formula: CNO (41.997989)

CAS ID: 71000-82-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.3.5.2 dihydroorotate dehydrogenase (quinone) (S)-dihydroorotate:quinone oxidoreductase
2.1.3.2 aspartate carbamoyltransferase carbamoyl-phosphate:L-aspartate carbamoyltransferase
2.4.2.10 orotate phosphoribosyltransferase orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase
2.7.13.3 histidine kinase ATP:protein-L-histidine N-phosphotransferase
2.7.4.14 UMP/CMP kinase ATP:CMP(UMP) phosphotransferase
2.7.4.22 UMP kinase ATP:UMP phosphotransferase
2.7.4.3 adenylate kinase ATP:AMP phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
3.5.1.2 glutaminase L-glutamine amidohydrolase
3.5.2.3 dihydroorotase (S)-dihydroorotate amidohydrolase
4.1.1.23 orotidine-5'-phosphate decarboxylase orotidine-5'-phosphate carboxy-lyase (UMP-forming)
6.3.4.16 carbamoyl-phosphate synthase (ammonia) carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
6.3.4.2 CTP synthase (glutamine hydrolysing) UTP:ammonia ligase (ADP-forming)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing) hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)


Proteins

Protein ID name full name
P00968 carB Carbamoyl phosphate synthase large chain
P05020 pyrC Dihydroorotase
P08244 pyrF Orotidine 5'-phosphate decarboxylase
P0A6F1 carA Carbamoyl phosphate synthase small chain
P0A763 ndk Nucleoside diphosphate kinase
P0A786 pyrB Aspartate carbamoyltransferase catalytic subunit
P0A7E1 pyrD Dihydroorotate dehydrogenase (quinone)
P0A7E3 pyrE Orotate phosphoribosyltransferase
P0A7E5 pyrG CTP synthase
P0A7E9 pyrH Uridylate kinase
P69441 adk Adenylate kinase