Interferon Signaling

Bonjardim CA, Ferreira PCP, Kroon EG. Interferons: Signaling, antiviral and viral evasion. Immunology Letters. 2009 Jan;122(1):1–11. doi: 10.1016/j.imlet.2008.11.002.; Gough DJ, Levy DE, Johnstone RW, Clarke CJ. IFNgamma signaling-does it mean JAK-STAT? Cytokine Growth Factor Rev. 2008 Oct;19(5-6):383–94. doi: 10.1016/j.cytogfr.2008.08.004. PMID: 18929502.; Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol. 2005 May;5(5):375–86. doi: 10.1038/nri1604. PMID: 15864272.; Uddin S, Platanias LC. Mechanisms of type-I interferon signal transduction. J Biochem Mol Biol. 2004 Nov 30;37(6):635–41. doi: 10.5483/bmbrep.2004.37.6.635. PMID: 15607020.; Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004 Feb;75(2):163–89. doi: 10.1189/jlb.0603252. PMID: 14525967.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Diphosphoric acid,P-(3,7,11-trimethyl-2,6,10-dodecatrienyl) ester

Formula: C15H28O7P2 (382.1310198)

CAS ID: 13058-04-3

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-)

Formula: C20H33O7P2 (447.1701428)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.8.4.-
1.3.1.91 tRNA-dihydrouridine20 synthase [NAD(P)+] tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase
2.1.1.56 mRNA (guanine-N7)-methyltransferase S-adenosyl-L-methionine:mRNA (guanine-N7)-methyltransferase
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.26 HECT-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming)
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.3.2.31 RBR-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RBR-type)
2.5.1.58 protein farnesyltransferase farnesyl-diphosphate:protein-cysteine farnesyltransferase
2.5.1.59 protein geranylgeranyltransferase type I geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
2.7.1.91 sphingosine kinase ATP:sphingoid base 1-phosphotransferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
2.7.7.50 mRNA guanylyltransferase GTP:mRNA guanylyltransferase
2.7.7.84 2'-5' oligoadenylate synthase ATP:ATP adenylyltransferase (2'-5' linkages-forming)
3.1.13.1 exoribonuclease II
3.1.13.4 poly(A)-specific ribonuclease
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.4.19.12 ubiquitinyl hydrolase 1
3.4.21.75 Furin
3.4.22.36 caspase-1
3.4.25.1 proteasome endopeptidase complex
3.5.4.37 double-stranded RNA adenine deaminase double-stranded RNA(adenine) aminohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.4.13 RNA helicase
3.6.5.3 protein-synthesizing GTPase GTP phosphohydrolase (mRNA-translation-assisting)
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase


Proteins

Protein ID name full name