Degradation of DVL
Wei W, Li M, Wang J, Nie F, Li L. The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein. Molecular and Cellular Biology. 2012 Oct 01;32(19):3903–12. doi: 10.1128/mcb.00251-12.; Gao C, Chen YG. Dishevelled: The hub of Wnt signaling. Cell Signal. 2010 May;22(5):717–27. doi: 10.1016/j.cellsig.2009.11.021. PMID: 20006983.; Zhang L, Gao X, Wen J, Ning Y, Chen Y. Dapper 1 Antagonizes Wnt Signaling by Promoting Dishevelled Degradation. Journal of Biological Chemistry. 2006 Mar;281(13):8607–12. doi: 10.1074/jbc.m600274200.; Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol. 2006 Apr;8(4):348–57. doi: 10.1038/ncb1381. PMID: 16547521.; Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A. NEDL1, a Novel Ubiquitin-protein Isopeptide Ligase for Dishevelled-1, Targets Mutant Superoxide Dismutase-1. Journal of Biological Chemistry. 2004 Mar;279(12):11327–35. doi: 10.1074/jbc.m312389200.; Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell. 2002 Apr;2(4):449–61. doi: 10.1016/s1534-5807(02)00140-5. PMID: 11970895.