DNA Repair
Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer. 2012 Dec;12(12):801–17. doi: 10.1038/nrc3399. PMID: 23175119.; Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.
Metabolites
2,6-diamino-5-formamido-4-hydroxypyrimidine
Formula: C5H7N5O2 (169.05997220000003)
CAS ID: 133310-38-0
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.14.11.- | |||
| 1.14.11.33 | DNA oxidative demethylase | methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) | |
| 1.14.11.53 | mRNA N6-methyladenine demethylase | mRNA-N6-methyladenosine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) | |
| 1.14.11.54 | mRNA N1-methyladenine demethylase | mRNA-N1-methyladenine,2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming) | |
| 2.1.1.357 | [histone H3]-lysine36 N-dimethyltransferase | S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-dimethyltransferase | |
| 2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase | DNA-6-O-methylguanine/DNA-4-O-methylthymine:[protein]-L-cysteine S-methyltransferase | |
| 2.3.1.286 | protein acetyllysine N-acetyltransferase | [protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming) | |
| 2.3.1.48 | histone acetyltransferase | acetyl-CoA:[protein]-L-lysine acetyltransferase | |
| 2.3.2.23 | E2 ubiquitin-conjugating enzyme | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase | |
| 2.3.2.26 | HECT-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming) | |
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.3.2.32 | cullin-RING-type E3 NEDD8 transferase | [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type) | |
| 2.7.1.78 | polynucleotide 5'-hydroxyl-kinase | ATP:5'-dephosphopolynucleotide 5'-phosphotransferase | |
| 2.7.10.2 | non-specific protein-tyrosine kinase | ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 2.7.11.22 | cyclin-dependent kinase | ATP:cyclin phosphotransferase | |
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | ATP:[DNA-directed RNA polymerase] phosphotransferase | |
| 2.7.11.24 | mitogen-activated protein kinase | ATP:protein phosphotransferase (MAPKK-activated) | |
| 2.7.7.48 | RNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed) | |
| 2.7.7.49 | RNA-directed DNA polymerase | deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) | |
| 2.7.7.6 | DNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) | |
| 2.7.7.7 | DNA-directed DNA polymerase | deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | |
| 3.1.11.2 | exodeoxyribonuclease III | ||
| 3.1.3.16 | protein-serine/threonine phosphatase | protein-serine/threonine-phosphate phosphohydrolase | |
| 3.1.3.32 | polynucleotide 3'-phosphatase | polynucleotide 3'-phosphohydrolase | |
| 3.1.4.1 | phosphodiesterase I | oligonucleotide 5'-nucleotidohydrolase | |
| 3.2.1.143 | poly(ADP-ribose) glycohydrolase | ||
| 3.2.2.21 | DNA-3-methyladenine glycosylase II | alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine) | |
| 3.2.2.29 | thymine-DNA glycosylase | thymine-DNA deoxyribohydrolase (thymine-releasing) | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 | ||
| 3.6.4.12 | DNA helicase | ||
| 3.6.4.13 | RNA helicase | ||
| 3.6.4.6 | vesicle-fusing ATPase | ATP phosphohydrolase (vesicle-fusing) | |
| 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase | |
| 5.2.1.8 | peptidylprolyl isomerase | Peptidylproline cis-trans-isomerase | |
| 5.6.2.1 | DNA topoisomerase | DNA topoisomerase | |
| 5.6.2.3 | DNA 5'-3' helicase | DNA 5'-3' helicase (ATP-hydrolysing) | |
| 5.6.2.4 | DNA 3'-5' helicase | DNA 3'-5' helicase (ATP-hydrolysing) | |
| 6.5.1.1 | DNA ligase (ATP) | poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP) |
Proteins
| Protein ID | name | full name |
|---|